Cyclodextrin–Amphiphilic Copolymer Supramolecular Assemblies for the Ocular Delivery of Natamycin

Cyclodextrin–Amphiphilic Copolymer Supramolecular Assemblies for the Ocular Delivery of Natamycin

Natamycin is the only drug approved for fungal keratitis treatment, but its low water solubility and low ocular penetration limit its efficacy. The purpose of this study was to overcome these limitations by encapsulating the drug in single or mixed micelles and poly(pseudo)rotaxanes. Soluplus and Pl...

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Bibliographic Details
Main Authors: Blanca Lorenzo-Veiga, Hakon Hrafn Sigurdsson, Thorsteinn Loftsson, Carmen Alvarez-Lorenzo
Format: Article
Language:English
Published: MDPI AG 2019-05-01
Series:Nanomaterials
Subjects:
block copolymers
cyclodextrins
ocular drug delivery
fungal keratitis
natamycin
mixed micelles
poly(pseudo)rotaxane
solubility
HET-CAM assay
ocular permeability
Online Access:https://www.mdpi.com/2079-4991/9/5/745

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