Mesenchymal Stem Cells Improve Cognitive Impairment and Reduce Aβ Deposition via Promoting AQP4 Polarity and Relieving Neuroinflammation in Rats With Chronic Hypertension-Induced Cerebral Small-Vessel Disease

Mesenchymal Stem Cells Improve Cognitive Impairment and Reduce Aβ Deposition via Promoting AQP4 Polarity and Relieving Neuroinflammation in Rats With Chronic Hypertension-Induced Cerebral Small-Vessel Disease

Cerebral small-vessel disease (CSVD) is the main cause of vascular cognitive impairment (VCI), and the accumulation of amyloid β-protein (Aβ) may be significantly involved in CSVD-induced VCI. The imbalance between Aβ production and clearance is believed to be an important pathological mechanism of...

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Bibliographic Details
Main Authors: Xiao lu Liu, Fu bing Ouyang, Liu ting Hu, Pei Sun, Jing Yang, Yuan jing Sun, Meng shi Liao, Lin fang Lan, Zhong Pei, Yu hua Fan
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Aging Neuroscience
Subjects:
mesenchymal stem cells
cerebral small-vessel disease
amyloid β-protein
aquaporin 4
neuroinflammation
vascular cognitive impairment
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2022.883503/full

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