Intestinal Organoids—Current and Future Applications
Recent technical advances in the stem cell field have enabled the in vitro generation of complex structures resembling whole organs termed organoids. Most of these approaches employ culture systems that allow stem cell-derived or tissue progenitor cells to self-organize into three-dimensional (3D)-s...
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| Format: | Article |
| Language: | English |
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MDPI AG
2016-10-01
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| Series: | Veterinary Sciences |
| Subjects: | |
| Online Access: | http://www.mdpi.com/2306-7381/3/4/31 |
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| author | Andre M. C. Meneses Kerstin Schneeberger Hedwig S. Kruitwagen Louis C. Penning Frank G. van Steenbeek Iwan A. Burgener Bart Spee |
| author_facet | Andre M. C. Meneses Kerstin Schneeberger Hedwig S. Kruitwagen Louis C. Penning Frank G. van Steenbeek Iwan A. Burgener Bart Spee |
| author_sort | Andre M. C. Meneses |
| collection | DOAJ |
| description | Recent technical advances in the stem cell field have enabled the in vitro generation of complex structures resembling whole organs termed organoids. Most of these approaches employ culture systems that allow stem cell-derived or tissue progenitor cells to self-organize into three-dimensional (3D)-structures. Since organoids can be grown from different species (human, mouse, cat, dog), organs (intestine, kidney, brain, liver), and from patient-derived induced pluripotent stem cells, they create significant prospects for modelling development and diseases, for toxicology and drug discovery studies, and in the field of regenerative medicine. Here, we report on intestinal stem cells, organoid culture, organoid disease modeling, transplantation, specifically covering the current and future uses of this exciting new insight model to the field of veterinary medicine. |
| first_indexed | 2024-12-16T06:39:47Z |
| format | Article |
| id | doaj.art-dd1c353e60e349819ff2f4e75030038c |
| institution | Directory Open Access Journal |
| issn | 2306-7381 |
| language | English |
| last_indexed | 2024-12-16T06:39:47Z |
| publishDate | 2016-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Veterinary Sciences |
| spelling | doaj.art-dd1c353e60e349819ff2f4e75030038c2022-12-21T22:40:43ZengMDPI AGVeterinary Sciences2306-73812016-10-01343110.3390/vetsci3040031vetsci3040031Intestinal Organoids—Current and Future ApplicationsAndre M. C. Meneses0Kerstin Schneeberger1Hedwig S. Kruitwagen2Louis C. Penning3Frank G. van Steenbeek4Iwan A. Burgener5Bart Spee6Institute of Animal Health and Production, Universidade Federal Rural da Amazônia, Avenida Presidente Tancredo Neves 66077-830, BrazilDepartment of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 104, Utrecht 3584 CM, The NetherlandsDepartment of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 104, Utrecht 3584 CM, The NetherlandsDepartment of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 104, Utrecht 3584 CM, The NetherlandsDepartment of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 104, Utrecht 3584 CM, The NetherlandsDepartment of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 104, Utrecht 3584 CM, The NetherlandsDepartment of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 104, Utrecht 3584 CM, The NetherlandsRecent technical advances in the stem cell field have enabled the in vitro generation of complex structures resembling whole organs termed organoids. Most of these approaches employ culture systems that allow stem cell-derived or tissue progenitor cells to self-organize into three-dimensional (3D)-structures. Since organoids can be grown from different species (human, mouse, cat, dog), organs (intestine, kidney, brain, liver), and from patient-derived induced pluripotent stem cells, they create significant prospects for modelling development and diseases, for toxicology and drug discovery studies, and in the field of regenerative medicine. Here, we report on intestinal stem cells, organoid culture, organoid disease modeling, transplantation, specifically covering the current and future uses of this exciting new insight model to the field of veterinary medicine.http://www.mdpi.com/2306-7381/3/4/31intestinal organoidsdogpractical applications |
| spellingShingle | Andre M. C. Meneses Kerstin Schneeberger Hedwig S. Kruitwagen Louis C. Penning Frank G. van Steenbeek Iwan A. Burgener Bart Spee Intestinal Organoids—Current and Future Applications Veterinary Sciences intestinal organoids dog practical applications |
| title | Intestinal Organoids—Current and Future Applications |
| title_full | Intestinal Organoids—Current and Future Applications |
| title_fullStr | Intestinal Organoids—Current and Future Applications |
| title_full_unstemmed | Intestinal Organoids—Current and Future Applications |
| title_short | Intestinal Organoids—Current and Future Applications |
| title_sort | intestinal organoids current and future applications |
| topic | intestinal organoids dog practical applications |
| url | http://www.mdpi.com/2306-7381/3/4/31 |
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