A-to-I miR-378a-3p editing can prevent melanoma progression via regulation of PARVA expression
In melanoma, reduced ADAR1 impairs A-to-I microRNA editing. Here, the authors show that miR-378a-3p undergoes this editing in non-metastatic cells and the edited form of miR-378a-3p binds to the PARVA oncogene, inhibiting its expression and preventing melanoma progression and metastasis.
Bibliographic Details
| Main Authors: |
Guermarie Velazquez-Torres,
Einav Shoshan,
Cristina Ivan,
Li Huang,
Enrique Fuentes-Mattei,
Harrison Paret,
Sun Jin Kim,
Cristian Rodriguez-Aguayo,
Victoria Xie,
Denise Brooks,
Steven J. M. Jones,
A. Gordon Robertson,
George Calin,
Gabriel Lopez-Berenstein,
Anil Sood,
Menashe Bar-Eli |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Portfolio
2018-01-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-018-02851-7
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