Dopamine regulates stimulus generalization in the human hippocampus
The ability to generalize previously learned information to novel situations is fundamental for adaptive behavior. However, too wide or too narrow generalization is linked to neuropsychiatric disorders. Previous research suggests that interactions between the dopaminergic system and the hippocampus...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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eLife Sciences Publications Ltd
2016-02-01
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| Series: | eLife |
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| Online Access: | https://elifesciences.org/articles/12678 |
| _version_ | 1811200403166986240 |
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| author | Thorsten Kahnt Philippe N Tobler |
| author_facet | Thorsten Kahnt Philippe N Tobler |
| author_sort | Thorsten Kahnt |
| collection | DOAJ |
| description | The ability to generalize previously learned information to novel situations is fundamental for adaptive behavior. However, too wide or too narrow generalization is linked to neuropsychiatric disorders. Previous research suggests that interactions between the dopaminergic system and the hippocampus may play a role in generalization, but whether and how the degree of generalization can be modulated via these pathways is currently unknown. Here, we addressed this question in humans using pharmacology, functional magnetic resonance imaging, and computational modeling. Blocking dopamine D2-receptors (D2R) altered generalization behavior as revealed by an increased kurtosis of the generalization gradient, and a decreased width of model-derived generalization parameters. Moreover, D2R-blockade modulated similarity-based responses in the hippocampus and decreased midbrain-hippocampal connectivity, which in turn correlated with individual differences in generalization. These results suggest that dopaminergic activity in the hippocampus may relate to the degree of generalization and highlight a potential target for treatment. |
| first_indexed | 2024-04-12T02:02:54Z |
| format | Article |
| id | doaj.art-dd2132dbb83b4b00820cd770e2526c43 |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-12T02:02:54Z |
| publishDate | 2016-02-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-dd2132dbb83b4b00820cd770e2526c432022-12-22T03:52:37ZengeLife Sciences Publications LtdeLife2050-084X2016-02-01510.7554/eLife.12678Dopamine regulates stimulus generalization in the human hippocampusThorsten Kahnt0https://orcid.org/0000-0002-3575-2670Philippe N Tobler1Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, United StatesDepartment of Economics, Laboratory for Social and Neural Systems Research, University of Zurich, Zürich, SwitzerlandThe ability to generalize previously learned information to novel situations is fundamental for adaptive behavior. However, too wide or too narrow generalization is linked to neuropsychiatric disorders. Previous research suggests that interactions between the dopaminergic system and the hippocampus may play a role in generalization, but whether and how the degree of generalization can be modulated via these pathways is currently unknown. Here, we addressed this question in humans using pharmacology, functional magnetic resonance imaging, and computational modeling. Blocking dopamine D2-receptors (D2R) altered generalization behavior as revealed by an increased kurtosis of the generalization gradient, and a decreased width of model-derived generalization parameters. Moreover, D2R-blockade modulated similarity-based responses in the hippocampus and decreased midbrain-hippocampal connectivity, which in turn correlated with individual differences in generalization. These results suggest that dopaminergic activity in the hippocampus may relate to the degree of generalization and highlight a potential target for treatment.https://elifesciences.org/articles/12678associative learningrewardfMRIdopaminehippocampus |
| spellingShingle | Thorsten Kahnt Philippe N Tobler Dopamine regulates stimulus generalization in the human hippocampus eLife associative learning reward fMRI dopamine hippocampus |
| title | Dopamine regulates stimulus generalization in the human hippocampus |
| title_full | Dopamine regulates stimulus generalization in the human hippocampus |
| title_fullStr | Dopamine regulates stimulus generalization in the human hippocampus |
| title_full_unstemmed | Dopamine regulates stimulus generalization in the human hippocampus |
| title_short | Dopamine regulates stimulus generalization in the human hippocampus |
| title_sort | dopamine regulates stimulus generalization in the human hippocampus |
| topic | associative learning reward fMRI dopamine hippocampus |
| url | https://elifesciences.org/articles/12678 |
| work_keys_str_mv | AT thorstenkahnt dopamineregulatesstimulusgeneralizationinthehumanhippocampus AT philippentobler dopamineregulatesstimulusgeneralizationinthehumanhippocampus |