Exploring the Microbiome in Gastric Cancer: Assessing Potential Implications and Contextualizing Microorganisms beyond <i>H. pylori</i> and Epstein-Barr Virus
While previous research has primarily focused on the impact of <i>H. pylori</i> and Epstein-Barr virus (EBV), emerging evidence suggests that other microbial influences, including viral and fungal infections, may also contribute to gastric cancer (GC) development. The intricate interacti...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-10-01
|
| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/15/20/4993 |
| _version_ | 1797574396227878912 |
|---|---|
| author | Wing Sum Shin Fuda Xie Bonan Chen Jun Yu Kwok Wai Lo Gary M. K. Tse Ka Fai To Wei Kang |
| author_facet | Wing Sum Shin Fuda Xie Bonan Chen Jun Yu Kwok Wai Lo Gary M. K. Tse Ka Fai To Wei Kang |
| author_sort | Wing Sum Shin |
| collection | DOAJ |
| description | While previous research has primarily focused on the impact of <i>H. pylori</i> and Epstein-Barr virus (EBV), emerging evidence suggests that other microbial influences, including viral and fungal infections, may also contribute to gastric cancer (GC) development. The intricate interactions between these microbes and the host’s immune response provide a more comprehensive understanding of gastric cancer pathogenesis, diagnosis, and treatment. The review highlights the roles of established players such as <i>H. pylori</i> and EBV and the potential impacts of gut bacteria, mainly <i>Lactobacillus</i>, <i>Streptococcus</i>, hepatitis B virus, hepatitis C virus, and fungi such as <i>Candida albicans</i>. Advanced sequencing technologies offer unprecedented insights into the complexities of the gastric microbiome, from microbial diversity to potential diagnostic applications. Furthermore, the review highlights the potential for advanced GC diagnosis and therapies through a better understanding of the gut microbiome. |
| first_indexed | 2024-03-10T21:23:01Z |
| format | Article |
| id | doaj.art-dd2218a468cc447cba0766a8fe85f3cf |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T21:23:01Z |
| publishDate | 2023-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-dd2218a468cc447cba0766a8fe85f3cf2023-11-19T15:59:02ZengMDPI AGCancers2072-66942023-10-011520499310.3390/cancers15204993Exploring the Microbiome in Gastric Cancer: Assessing Potential Implications and Contextualizing Microorganisms beyond <i>H. pylori</i> and Epstein-Barr VirusWing Sum Shin0Fuda Xie1Bonan Chen2Jun Yu3Kwok Wai Lo4Gary M. K. Tse5Ka Fai To6Wei Kang7State Key Laboratory of Translational Oncology, Department of Anatomical and Cellular Pathology, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong 999077, ChinaState Key Laboratory of Translational Oncology, Department of Anatomical and Cellular Pathology, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong 999077, ChinaState Key Laboratory of Translational Oncology, Department of Anatomical and Cellular Pathology, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong 999077, ChinaState Key Laboratory of Digestive Disease, Institute of Digestive Disease, The Chinese University of Hong Kong, Hong Kong 999077, ChinaState Key Laboratory of Translational Oncology, Department of Anatomical and Cellular Pathology, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong 999077, ChinaState Key Laboratory of Translational Oncology, Department of Anatomical and Cellular Pathology, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong 999077, ChinaState Key Laboratory of Translational Oncology, Department of Anatomical and Cellular Pathology, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong 999077, ChinaState Key Laboratory of Translational Oncology, Department of Anatomical and Cellular Pathology, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong 999077, ChinaWhile previous research has primarily focused on the impact of <i>H. pylori</i> and Epstein-Barr virus (EBV), emerging evidence suggests that other microbial influences, including viral and fungal infections, may also contribute to gastric cancer (GC) development. The intricate interactions between these microbes and the host’s immune response provide a more comprehensive understanding of gastric cancer pathogenesis, diagnosis, and treatment. The review highlights the roles of established players such as <i>H. pylori</i> and EBV and the potential impacts of gut bacteria, mainly <i>Lactobacillus</i>, <i>Streptococcus</i>, hepatitis B virus, hepatitis C virus, and fungi such as <i>Candida albicans</i>. Advanced sequencing technologies offer unprecedented insights into the complexities of the gastric microbiome, from microbial diversity to potential diagnostic applications. Furthermore, the review highlights the potential for advanced GC diagnosis and therapies through a better understanding of the gut microbiome.https://www.mdpi.com/2072-6694/15/20/4993gastric cancermicrobiome<i>Lactobacillus</i><i>Streptococcus</i>HBVHCV |
| spellingShingle | Wing Sum Shin Fuda Xie Bonan Chen Jun Yu Kwok Wai Lo Gary M. K. Tse Ka Fai To Wei Kang Exploring the Microbiome in Gastric Cancer: Assessing Potential Implications and Contextualizing Microorganisms beyond <i>H. pylori</i> and Epstein-Barr Virus Cancers gastric cancer microbiome <i>Lactobacillus</i> <i>Streptococcus</i> HBV HCV |
| title | Exploring the Microbiome in Gastric Cancer: Assessing Potential Implications and Contextualizing Microorganisms beyond <i>H. pylori</i> and Epstein-Barr Virus |
| title_full | Exploring the Microbiome in Gastric Cancer: Assessing Potential Implications and Contextualizing Microorganisms beyond <i>H. pylori</i> and Epstein-Barr Virus |
| title_fullStr | Exploring the Microbiome in Gastric Cancer: Assessing Potential Implications and Contextualizing Microorganisms beyond <i>H. pylori</i> and Epstein-Barr Virus |
| title_full_unstemmed | Exploring the Microbiome in Gastric Cancer: Assessing Potential Implications and Contextualizing Microorganisms beyond <i>H. pylori</i> and Epstein-Barr Virus |
| title_short | Exploring the Microbiome in Gastric Cancer: Assessing Potential Implications and Contextualizing Microorganisms beyond <i>H. pylori</i> and Epstein-Barr Virus |
| title_sort | exploring the microbiome in gastric cancer assessing potential implications and contextualizing microorganisms beyond i h pylori i and epstein barr virus |
| topic | gastric cancer microbiome <i>Lactobacillus</i> <i>Streptococcus</i> HBV HCV |
| url | https://www.mdpi.com/2072-6694/15/20/4993 |
| work_keys_str_mv | AT wingsumshin exploringthemicrobiomeingastriccancerassessingpotentialimplicationsandcontextualizingmicroorganismsbeyondihpyloriiandepsteinbarrvirus AT fudaxie exploringthemicrobiomeingastriccancerassessingpotentialimplicationsandcontextualizingmicroorganismsbeyondihpyloriiandepsteinbarrvirus AT bonanchen exploringthemicrobiomeingastriccancerassessingpotentialimplicationsandcontextualizingmicroorganismsbeyondihpyloriiandepsteinbarrvirus AT junyu exploringthemicrobiomeingastriccancerassessingpotentialimplicationsandcontextualizingmicroorganismsbeyondihpyloriiandepsteinbarrvirus AT kwokwailo exploringthemicrobiomeingastriccancerassessingpotentialimplicationsandcontextualizingmicroorganismsbeyondihpyloriiandepsteinbarrvirus AT garymktse exploringthemicrobiomeingastriccancerassessingpotentialimplicationsandcontextualizingmicroorganismsbeyondihpyloriiandepsteinbarrvirus AT kafaito exploringthemicrobiomeingastriccancerassessingpotentialimplicationsandcontextualizingmicroorganismsbeyondihpyloriiandepsteinbarrvirus AT weikang exploringthemicrobiomeingastriccancerassessingpotentialimplicationsandcontextualizingmicroorganismsbeyondihpyloriiandepsteinbarrvirus |