Vitamin D Supplementation and COVID-19
Coronavirus Disease 2019 (COVID-19) happened due to Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection. It is the third coronavirus causing a pandemic. Cases of COVID-19 have increased rapidly. Epidemiological studies show droplets as a medium of transmission of this virus. The h...
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| Format: | Article |
| Language: | English |
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Universitas Airlangga
2022-01-01
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| Series: | Jurnal Respirasi |
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| Online Access: | https://e-journal.unair.ac.id/JR/article/view/31024 |
| _version_ | 1818324432737796096 |
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| author | Gracia Dewitacita Tanaya Willa Mettacita Tanaya Ayu Hutami Syarif |
| author_facet | Gracia Dewitacita Tanaya Willa Mettacita Tanaya Ayu Hutami Syarif |
| author_sort | Gracia Dewitacita Tanaya |
| collection | DOAJ |
| description | Coronavirus Disease 2019 (COVID-19) happened due to Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection. It is the third coronavirus causing a pandemic. Cases of COVID-19 have increased rapidly. Epidemiological studies show droplets as a medium of transmission of this virus. The high rate of transmission and the death rate create urgency on the management of COVID-19. Unfortunately, until now there is no definitive therapy for the SARS-CoV-2 virus. Several potential therapies, including antivirals, immunomodulatory agents, convalescent plasma transfusions, and supportive therapies such as vitamin D supplementation, have been applied in the management of COVID-19. As a hormone, vitamin D has an immunomodulatory effect used in supportive therapy for various immune-related diseases and respiratory system infections. The immunomodulatory effects of vitamin D are strengthening the physical barrier (cell junction), the specific immune system (adaptive immunity), and the non-specific immune system (innate immunity). Vitamin D is known to suppress pro-inflammatory cytokines and increase the production of anti-inflammatory cytokines. In addition, vitamin D also performs as a substantial part in the induction of ACE2 receptors which gives a weighty influence on pathogenesis of COVID-19. Vitamin D deficiency can amplify the risk of infections including COVID-19. Presently, clinical trials of vitamin D supplementation and COVID-19 are limited. This literature review further examined the role of vitamin D supplementation in COVID-19. |
| first_indexed | 2024-12-13T11:28:30Z |
| format | Article |
| id | doaj.art-dd22dc00010a448c8c170d1627085cee |
| institution | Directory Open Access Journal |
| issn | 2407-0831 2621-8372 |
| language | English |
| last_indexed | 2024-12-13T11:28:30Z |
| publishDate | 2022-01-01 |
| publisher | Universitas Airlangga |
| record_format | Article |
| series | Jurnal Respirasi |
| spelling | doaj.art-dd22dc00010a448c8c170d1627085cee2022-12-21T23:48:04ZengUniversitas AirlanggaJurnal Respirasi2407-08312621-83722022-01-01816068http://dx.doi.org/10.20473/jr.v8-I.1.2022.60-68Vitamin D Supplementation and COVID-19Gracia Dewitacita Tanaya0https://orcid.org/0000-0002-3000-3654Willa Mettacita Tanaya1https://orcid.org/0000-0003-4412-1560Ayu Hutami Syarif2https://orcid.org/0000-0001-8033-4462BaliMed Buleleng Hospital IndonesiaDepartment of Internal Medicine, Faculty of Medicine, Universitas Airlangga, Surabaya, IndonesiaMedical University Graz AustriaCoronavirus Disease 2019 (COVID-19) happened due to Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection. It is the third coronavirus causing a pandemic. Cases of COVID-19 have increased rapidly. Epidemiological studies show droplets as a medium of transmission of this virus. The high rate of transmission and the death rate create urgency on the management of COVID-19. Unfortunately, until now there is no definitive therapy for the SARS-CoV-2 virus. Several potential therapies, including antivirals, immunomodulatory agents, convalescent plasma transfusions, and supportive therapies such as vitamin D supplementation, have been applied in the management of COVID-19. As a hormone, vitamin D has an immunomodulatory effect used in supportive therapy for various immune-related diseases and respiratory system infections. The immunomodulatory effects of vitamin D are strengthening the physical barrier (cell junction), the specific immune system (adaptive immunity), and the non-specific immune system (innate immunity). Vitamin D is known to suppress pro-inflammatory cytokines and increase the production of anti-inflammatory cytokines. In addition, vitamin D also performs as a substantial part in the induction of ACE2 receptors which gives a weighty influence on pathogenesis of COVID-19. Vitamin D deficiency can amplify the risk of infections including COVID-19. Presently, clinical trials of vitamin D supplementation and COVID-19 are limited. This literature review further examined the role of vitamin D supplementation in COVID-19.https://e-journal.unair.ac.id/JR/article/view/31024vitamin dimmunomodulatory effectcovid-19immunopathogenesis |
| spellingShingle | Gracia Dewitacita Tanaya Willa Mettacita Tanaya Ayu Hutami Syarif Vitamin D Supplementation and COVID-19 Jurnal Respirasi vitamin d immunomodulatory effect covid-19 immunopathogenesis |
| title | Vitamin D Supplementation and COVID-19 |
| title_full | Vitamin D Supplementation and COVID-19 |
| title_fullStr | Vitamin D Supplementation and COVID-19 |
| title_full_unstemmed | Vitamin D Supplementation and COVID-19 |
| title_short | Vitamin D Supplementation and COVID-19 |
| title_sort | vitamin d supplementation and covid 19 |
| topic | vitamin d immunomodulatory effect covid-19 immunopathogenesis |
| url | https://e-journal.unair.ac.id/JR/article/view/31024 |
| work_keys_str_mv | AT graciadewitacitatanaya vitamindsupplementationandcovid19 AT willamettacitatanaya vitamindsupplementationandcovid19 AT ayuhutamisyarif vitamindsupplementationandcovid19 |