Postnatal weight gain in very low birth weight infants in Beijing and the risk of retinopathy of prematurity
<AIM:> To analyze the low weight gain (WG) from birth to 4 and 6wk of life to predict the development of retinopathy of prematurity (ROP) among very low birth weight (VLBW) preterm babies. <METHODS:> Three hundred and three newborns with VLBW were analyzed. Body weight measurements we...
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| Format: | Article |
| Language: | English |
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Press of International Journal of Ophthalmology (IJO PRESS)
2015-12-01
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| Series: | International Journal of Ophthalmology |
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| Online Access: | http://www.ijo.cn/en_publish/2015/6/20150623.pdf |
| _version_ | 1818681729173422080 |
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| author | Zong-Hua Wang Peng-Fen Gao Hua Bai Yao-Yu Li |
| author_facet | Zong-Hua Wang Peng-Fen Gao Hua Bai Yao-Yu Li |
| author_sort | Zong-Hua Wang |
| collection | DOAJ |
| description | <AIM:> To analyze the low weight gain (WG) from birth to 4 and 6wk of life to predict the development of retinopathy of prematurity (ROP) among very low birth weight (VLBW) preterm babies.
<METHODS:> Three hundred and three newborns with VLBW were analyzed. Body weight measurements were recorded weekly. In all patients, the proportion of the WG was defined as the preterm weight measured at the 4th and 6th weeks of life minus the birth weight (BW) divided by the BW. Other risk factors for ROP were also analyzed.
<RESULTS:> Mean gestational age and mean BW of the whole cohort were 29.56±1.44wk and 1270.58±176.18g respectively. WG proportion at 4wk postnatal age (18.89%±13.58%) were significantly lower in infants with ROP (P=0.003). WG proportion at 6wk was not different between ROP and no ROP group (42.48%±20.36% vs 46.43%±15.65% P=0.118). When all the other risk factors significant for ROP were included in the logistic regression poor WG did not arise as an independent risk factor. Area under the ROC curve was 0.591 (95%CI: 0.515-0.666; P=0.016). For ROP, the best discriminative cutoff of 18.06% of the proportional WG at the 4th week over the BW, sensitivity and specificity values were 67.3% and 50.0% respectively.
<CONCLUSION:> Low WG proportion in the first 4wk of life is maybe an additional predictor of ROP in very low BW infants. Preterm babies with low BW and low WG proportion should be followed closely for ROP. |
| first_indexed | 2024-12-17T10:07:34Z |
| format | Article |
| id | doaj.art-dd249861746e4943886f02947afed100 |
| institution | Directory Open Access Journal |
| issn | 2222-3959 2227-4898 |
| language | English |
| last_indexed | 2024-12-17T10:07:34Z |
| publishDate | 2015-12-01 |
| publisher | Press of International Journal of Ophthalmology (IJO PRESS) |
| record_format | Article |
| series | International Journal of Ophthalmology |
| spelling | doaj.art-dd249861746e4943886f02947afed1002022-12-21T21:53:08ZengPress of International Journal of Ophthalmology (IJO PRESS)International Journal of Ophthalmology2222-39592227-48982015-12-01861207121010.3980/j.issn.2222-3959.2015.06.23Postnatal weight gain in very low birth weight infants in Beijing and the risk of retinopathy of prematurityZong-Hua Wang0Peng-Fen Gao1Hua Bai2Yao-Yu Li3Department of Ophthalmology, Beijing General Hospital of the Chinese PLA, Beijing 100700, ChinaDepartment of Ophthalmology, Fuzhou General Hospital of the Chinese PLA, Fuzhou 350025, Fujian Province, ChinaDepartment of Ophthalmology, Beijing General Hospital of the Chinese PLA, Beijing 100700, ChinaDepartment of Ophthalmology, Beijing General Hospital of the Chinese PLA, Beijing 100700, China<AIM:> To analyze the low weight gain (WG) from birth to 4 and 6wk of life to predict the development of retinopathy of prematurity (ROP) among very low birth weight (VLBW) preterm babies. <METHODS:> Three hundred and three newborns with VLBW were analyzed. Body weight measurements were recorded weekly. In all patients, the proportion of the WG was defined as the preterm weight measured at the 4th and 6th weeks of life minus the birth weight (BW) divided by the BW. Other risk factors for ROP were also analyzed. <RESULTS:> Mean gestational age and mean BW of the whole cohort were 29.56±1.44wk and 1270.58±176.18g respectively. WG proportion at 4wk postnatal age (18.89%±13.58%) were significantly lower in infants with ROP (P=0.003). WG proportion at 6wk was not different between ROP and no ROP group (42.48%±20.36% vs 46.43%±15.65% P=0.118). When all the other risk factors significant for ROP were included in the logistic regression poor WG did not arise as an independent risk factor. Area under the ROC curve was 0.591 (95%CI: 0.515-0.666; P=0.016). For ROP, the best discriminative cutoff of 18.06% of the proportional WG at the 4th week over the BW, sensitivity and specificity values were 67.3% and 50.0% respectively. <CONCLUSION:> Low WG proportion in the first 4wk of life is maybe an additional predictor of ROP in very low BW infants. Preterm babies with low BW and low WG proportion should be followed closely for ROP.http://www.ijo.cn/en_publish/2015/6/20150623.pdfretinopathy of prematurityweight gainrisk factorsweight gain proportion |
| spellingShingle | Zong-Hua Wang Peng-Fen Gao Hua Bai Yao-Yu Li Postnatal weight gain in very low birth weight infants in Beijing and the risk of retinopathy of prematurity International Journal of Ophthalmology retinopathy of prematurity weight gain risk factors weight gain proportion |
| title | Postnatal weight gain in very low birth weight infants in Beijing and the risk of retinopathy of prematurity |
| title_full | Postnatal weight gain in very low birth weight infants in Beijing and the risk of retinopathy of prematurity |
| title_fullStr | Postnatal weight gain in very low birth weight infants in Beijing and the risk of retinopathy of prematurity |
| title_full_unstemmed | Postnatal weight gain in very low birth weight infants in Beijing and the risk of retinopathy of prematurity |
| title_short | Postnatal weight gain in very low birth weight infants in Beijing and the risk of retinopathy of prematurity |
| title_sort | postnatal weight gain in very low birth weight infants in beijing and the risk of retinopathy of prematurity |
| topic | retinopathy of prematurity weight gain risk factors weight gain proportion |
| url | http://www.ijo.cn/en_publish/2015/6/20150623.pdf |
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