Functional Polarity of Microvascular Brain Endothelial Cells Supported by Neurovascular Unit Computational Model of Large Neutral Amino Acid Homeostasis

Functional Polarity of Microvascular Brain Endothelial Cells Supported by Neurovascular Unit Computational Model of Large Neutral Amino Acid Homeostasis

The homeostatic regulation of large neutral amino acid (LNAA) concentration in the brain interstitial fluid (ISF) is essential for proper brain function. LNAA passage into the brain is primarily mediated by the complex and dynamic interactions between various solute carrier (SLC) transporters expres...

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Bibliographic Details
Main Authors:	Mehdi Taslimifar, Stefano Buoso, Francois Verrey, Vartan Kurtcuoglu
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2018-03-01
Series:	Frontiers in Physiology
Subjects:	blood brain barrier neurovascular unit amino acid transporter large neutral amino acid SLC7A5/LAT1
Online Access:	http://journal.frontiersin.org/article/10.3389/fphys.2018.00171/full

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