Circulating Tumor Cells and Extracellular Nucleic Acids in Breast Cancer
Circulating tumor cells (CTCs) are defined as tumor cells circulating in the peripheral blood of patients, shed from either the primary tumor or from its metastases. The detection of circulating tumor cells (CTCs) in the peripheral blood of breast cancer patients may account for the different steps...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Kosin University College of Medicine
2012-06-01
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| Series: | Kosin Medical Journal |
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| Online Access: | http://www.kosinmedj.org/upload/pdf/ksmc027-1-01.pdf |
| _version_ | 1797989199584952320 |
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| author | Dong Won Ryu Chung Han Lee |
| author_facet | Dong Won Ryu Chung Han Lee |
| author_sort | Dong Won Ryu |
| collection | DOAJ |
| description | Circulating tumor cells (CTCs) are defined as tumor cells circulating in the peripheral blood of patients, shed from either the primary tumor or from its metastases. The detection of circulating tumor cells (CTCs) in the peripheral blood of breast cancer patients may account for the different steps in the biologic progression of the disease. The detection of microscopic disease in patients with breast cancer is imperative to prognosis and can predict the efficacy of targeted treatments. In general, there are two main methods for their detection. These are based on cytometric and nucleic acid manipulation. Both methods generally require an enrichment step to increase sensitivity of the assay. This step is based on either detection of specific surface markers using immuno-selection and/or on morphological features, such as cell size or density. We review the methods of detecting CTCs, their prognostic implications, and opportunities to exploit the properties of CTCs to develop personalized therapy. |
| first_indexed | 2024-04-11T08:16:25Z |
| format | Article |
| id | doaj.art-dd254b9ebb8e4556bc89592d3648e8b3 |
| institution | Directory Open Access Journal |
| issn | 2005-9531 |
| language | English |
| last_indexed | 2024-04-11T08:16:25Z |
| publishDate | 2012-06-01 |
| publisher | Kosin University College of Medicine |
| record_format | Article |
| series | Kosin Medical Journal |
| spelling | doaj.art-dd254b9ebb8e4556bc89592d3648e8b32022-12-22T04:35:10ZengKosin University College of MedicineKosin Medical Journal2005-95312012-06-012711910.7180/kmj.2012.27.1.11Circulating Tumor Cells and Extracellular Nucleic Acids in Breast CancerDong Won Ryu0Chung Han Lee1Department of Surgery, College of Medicine, Kosin University, Busan, Korea.Department of Surgery, College of Medicine, Kosin University, Busan, Korea.Circulating tumor cells (CTCs) are defined as tumor cells circulating in the peripheral blood of patients, shed from either the primary tumor or from its metastases. The detection of circulating tumor cells (CTCs) in the peripheral blood of breast cancer patients may account for the different steps in the biologic progression of the disease. The detection of microscopic disease in patients with breast cancer is imperative to prognosis and can predict the efficacy of targeted treatments. In general, there are two main methods for their detection. These are based on cytometric and nucleic acid manipulation. Both methods generally require an enrichment step to increase sensitivity of the assay. This step is based on either detection of specific surface markers using immuno-selection and/or on morphological features, such as cell size or density. We review the methods of detecting CTCs, their prognostic implications, and opportunities to exploit the properties of CTCs to develop personalized therapy.http://www.kosinmedj.org/upload/pdf/ksmc027-1-01.pdfbreast cancercirculating tumor cellsextracellular nucleic acids |
| spellingShingle | Dong Won Ryu Chung Han Lee Circulating Tumor Cells and Extracellular Nucleic Acids in Breast Cancer Kosin Medical Journal breast cancer circulating tumor cells extracellular nucleic acids |
| title | Circulating Tumor Cells and Extracellular Nucleic Acids in Breast Cancer |
| title_full | Circulating Tumor Cells and Extracellular Nucleic Acids in Breast Cancer |
| title_fullStr | Circulating Tumor Cells and Extracellular Nucleic Acids in Breast Cancer |
| title_full_unstemmed | Circulating Tumor Cells and Extracellular Nucleic Acids in Breast Cancer |
| title_short | Circulating Tumor Cells and Extracellular Nucleic Acids in Breast Cancer |
| title_sort | circulating tumor cells and extracellular nucleic acids in breast cancer |
| topic | breast cancer circulating tumor cells extracellular nucleic acids |
| url | http://www.kosinmedj.org/upload/pdf/ksmc027-1-01.pdf |
| work_keys_str_mv | AT dongwonryu circulatingtumorcellsandextracellularnucleicacidsinbreastcancer AT chunghanlee circulatingtumorcellsandextracellularnucleicacidsinbreastcancer |