A Prediction Model for In-Hospital Mortality of Acute Exacerbations of Chronic Obstructive Pulmonary Disease Patients Based on Red Cell Distribution Width-to-Platelet Ratio
Shi Chen,1 Yi Shi,1 Bingzhu Hu,1 Jie Huang2 1Department of Pulmonary and Critical Care Medicine, Affiliated Hospital of Jianghan University, Wuhan City, Hubei, 430000, People’s Republic of China; 2Department of Respiratory Medicine, Shanghai Xuhui Central Hospital, Zhongshan-Xuhui Hospital, Fudan Un...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Dove Medical Press
2023-09-01
|
| Series: | International Journal of COPD |
| Subjects: | |
| Online Access: | https://www.dovepress.com/a-prediction-model-for-in-hospital-mortality-of-acute-exacerbations-of-peer-reviewed-fulltext-article-COPD |
| _version_ | 1797678121648914432 |
|---|---|
| author | Chen S Shi Y Hu B Huang J |
| author_facet | Chen S Shi Y Hu B Huang J |
| author_sort | Chen S |
| collection | DOAJ |
| description | Shi Chen,1 Yi Shi,1 Bingzhu Hu,1 Jie Huang2 1Department of Pulmonary and Critical Care Medicine, Affiliated Hospital of Jianghan University, Wuhan City, Hubei, 430000, People’s Republic of China; 2Department of Respiratory Medicine, Shanghai Xuhui Central Hospital, Zhongshan-Xuhui Hospital, Fudan University, Shanghai, 200031, People’s Republic of ChinaCorrespondence: Jie Huang, Shanghai Xuhui Central Hospital, Zhongshan-Xuhui Hospital, 966 Huaihai Zhong Lu, Xuhui District, Shanghai, Tel +86-13585823471, Email syarhuang@163.comPurpose: To explore the association between red cell distribution width (RDW)-to-platelet ratio (RPR) and in-hospital mortality of acute exacerbations of chronic obstructive pulmonary disease (AECOPD) patients and establish a prediction model based on RPR and other predictors.Material and Methods: This cohort study included 1922 AECOPD patients aged ≥ 18 years in the Medical Information Mart for Intensive Care (MIMIC)-III and MIMIC-IV as well as 1738 AECOPD patients from eICU Collaborative Research Database (eICU-CRD). Possible confounding factors were screened out by univariate logistic regression, and multivariable logistic regression was applied to evaluate the association between RPR and in-hospital mortality of AECOPD patients. The area under the curve (AUC), calibration curve and decision curve analysis (DCA) curve were plotted to evaluate the predictive value of the model. The median follow-up time was 3.14 (1.87, 6.25) day.Results: At the end of follow-up, there were 1660 patients survived and 262 subjects died. After adjusting for confounders, we found that Log (RPR× 1000) was linked with elevated risk of in-hospital mortality of AECOPD patients [odds ratio (OR)=1.36, 95% confidence interval (CI): 1.01– 1.84]. The prediction model was constructed using predictors including Log (RPR× 1000), age, malignant cancer, atrial fibrillation, ventilation, renal failure, diastolic blood pressure (DBP), temperature, Glasgow Coma Scale (GCS) score, white blood cell (WBC), creatinine, blood urea nitrogen (BUN), hemoglobin, infectious diseases and anion gap. The AUC of the prediction model was 0.785 (95% CI: 0.751– 0.820) in the training set, 0.721 (95% CI: 0.662– 0.780) in the testing set, and 0.795 (95% CI: 0.762– 0.827) in the validation set.Conclusion: RPR was associated with the in-hospital mortality of AECOPD patients. The prediction model for the in-hospital mortality of AECOPD patients based on RPR and other predictors presented good predictive performance, which might help the clinicians to quickly identify AECOPD patients at high risk of in-hospital mortality.Keywords: red cell distribution width-to-platelet ratio, acute exacerbations of chronic obstructive pulmonary disease, red cell distribution width, platelet ratio |
| first_indexed | 2024-03-11T22:54:12Z |
| format | Article |
| id | doaj.art-dd27727c29cb4eb0ad4b9284c98c1e74 |
| institution | Directory Open Access Journal |
| issn | 1178-2005 |
| language | English |
| last_indexed | 2024-03-11T22:54:12Z |
| publishDate | 2023-09-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | International Journal of COPD |
| spelling | doaj.art-dd27727c29cb4eb0ad4b9284c98c1e742023-09-21T19:09:00ZengDove Medical PressInternational Journal of COPD1178-20052023-09-01Volume 182079209186837A Prediction Model for In-Hospital Mortality of Acute Exacerbations of Chronic Obstructive Pulmonary Disease Patients Based on Red Cell Distribution Width-to-Platelet RatioChen SShi YHu BHuang JShi Chen,1 Yi Shi,1 Bingzhu Hu,1 Jie Huang2 1Department of Pulmonary and Critical Care Medicine, Affiliated Hospital of Jianghan University, Wuhan City, Hubei, 430000, People’s Republic of China; 2Department of Respiratory Medicine, Shanghai Xuhui Central Hospital, Zhongshan-Xuhui Hospital, Fudan University, Shanghai, 200031, People’s Republic of ChinaCorrespondence: Jie Huang, Shanghai Xuhui Central Hospital, Zhongshan-Xuhui Hospital, 966 Huaihai Zhong Lu, Xuhui District, Shanghai, Tel +86-13585823471, Email syarhuang@163.comPurpose: To explore the association between red cell distribution width (RDW)-to-platelet ratio (RPR) and in-hospital mortality of acute exacerbations of chronic obstructive pulmonary disease (AECOPD) patients and establish a prediction model based on RPR and other predictors.Material and Methods: This cohort study included 1922 AECOPD patients aged ≥ 18 years in the Medical Information Mart for Intensive Care (MIMIC)-III and MIMIC-IV as well as 1738 AECOPD patients from eICU Collaborative Research Database (eICU-CRD). Possible confounding factors were screened out by univariate logistic regression, and multivariable logistic regression was applied to evaluate the association between RPR and in-hospital mortality of AECOPD patients. The area under the curve (AUC), calibration curve and decision curve analysis (DCA) curve were plotted to evaluate the predictive value of the model. The median follow-up time was 3.14 (1.87, 6.25) day.Results: At the end of follow-up, there were 1660 patients survived and 262 subjects died. After adjusting for confounders, we found that Log (RPR× 1000) was linked with elevated risk of in-hospital mortality of AECOPD patients [odds ratio (OR)=1.36, 95% confidence interval (CI): 1.01– 1.84]. The prediction model was constructed using predictors including Log (RPR× 1000), age, malignant cancer, atrial fibrillation, ventilation, renal failure, diastolic blood pressure (DBP), temperature, Glasgow Coma Scale (GCS) score, white blood cell (WBC), creatinine, blood urea nitrogen (BUN), hemoglobin, infectious diseases and anion gap. The AUC of the prediction model was 0.785 (95% CI: 0.751– 0.820) in the training set, 0.721 (95% CI: 0.662– 0.780) in the testing set, and 0.795 (95% CI: 0.762– 0.827) in the validation set.Conclusion: RPR was associated with the in-hospital mortality of AECOPD patients. The prediction model for the in-hospital mortality of AECOPD patients based on RPR and other predictors presented good predictive performance, which might help the clinicians to quickly identify AECOPD patients at high risk of in-hospital mortality.Keywords: red cell distribution width-to-platelet ratio, acute exacerbations of chronic obstructive pulmonary disease, red cell distribution width, platelet ratiohttps://www.dovepress.com/a-prediction-model-for-in-hospital-mortality-of-acute-exacerbations-of-peer-reviewed-fulltext-article-COPDred cell distribution width to platelet ratioacute exacerbations of chronic obstructive pulmonary diseasered cell distribution widthplatelet ratio |
| spellingShingle | Chen S Shi Y Hu B Huang J A Prediction Model for In-Hospital Mortality of Acute Exacerbations of Chronic Obstructive Pulmonary Disease Patients Based on Red Cell Distribution Width-to-Platelet Ratio International Journal of COPD red cell distribution width to platelet ratio acute exacerbations of chronic obstructive pulmonary disease red cell distribution width platelet ratio |
| title | A Prediction Model for In-Hospital Mortality of Acute Exacerbations of Chronic Obstructive Pulmonary Disease Patients Based on Red Cell Distribution Width-to-Platelet Ratio |
| title_full | A Prediction Model for In-Hospital Mortality of Acute Exacerbations of Chronic Obstructive Pulmonary Disease Patients Based on Red Cell Distribution Width-to-Platelet Ratio |
| title_fullStr | A Prediction Model for In-Hospital Mortality of Acute Exacerbations of Chronic Obstructive Pulmonary Disease Patients Based on Red Cell Distribution Width-to-Platelet Ratio |
| title_full_unstemmed | A Prediction Model for In-Hospital Mortality of Acute Exacerbations of Chronic Obstructive Pulmonary Disease Patients Based on Red Cell Distribution Width-to-Platelet Ratio |
| title_short | A Prediction Model for In-Hospital Mortality of Acute Exacerbations of Chronic Obstructive Pulmonary Disease Patients Based on Red Cell Distribution Width-to-Platelet Ratio |
| title_sort | prediction model for in hospital mortality of acute exacerbations of chronic obstructive pulmonary disease patients based on red cell distribution width to platelet ratio |
| topic | red cell distribution width to platelet ratio acute exacerbations of chronic obstructive pulmonary disease red cell distribution width platelet ratio |
| url | https://www.dovepress.com/a-prediction-model-for-in-hospital-mortality-of-acute-exacerbations-of-peer-reviewed-fulltext-article-COPD |
| work_keys_str_mv | AT chens apredictionmodelforinhospitalmortalityofacuteexacerbationsofchronicobstructivepulmonarydiseasepatientsbasedonredcelldistributionwidthtoplateletratio AT shiy apredictionmodelforinhospitalmortalityofacuteexacerbationsofchronicobstructivepulmonarydiseasepatientsbasedonredcelldistributionwidthtoplateletratio AT hub apredictionmodelforinhospitalmortalityofacuteexacerbationsofchronicobstructivepulmonarydiseasepatientsbasedonredcelldistributionwidthtoplateletratio AT huangj apredictionmodelforinhospitalmortalityofacuteexacerbationsofchronicobstructivepulmonarydiseasepatientsbasedonredcelldistributionwidthtoplateletratio AT chens predictionmodelforinhospitalmortalityofacuteexacerbationsofchronicobstructivepulmonarydiseasepatientsbasedonredcelldistributionwidthtoplateletratio AT shiy predictionmodelforinhospitalmortalityofacuteexacerbationsofchronicobstructivepulmonarydiseasepatientsbasedonredcelldistributionwidthtoplateletratio AT hub predictionmodelforinhospitalmortalityofacuteexacerbationsofchronicobstructivepulmonarydiseasepatientsbasedonredcelldistributionwidthtoplateletratio AT huangj predictionmodelforinhospitalmortalityofacuteexacerbationsofchronicobstructivepulmonarydiseasepatientsbasedonredcelldistributionwidthtoplateletratio |