Wnt and Neuregulin1/ErbB signalling extends 3D culture of hormone responsive mammary organoids
Three-dimensional culture systems and organoids for mammary glands are important to understand mammary gland development. Here, the authors identify conditions (including Neuregulin 1 and R-spondin 1) that allow the culture of organoids that are responsive to hormonal stimulation for up to 2.5 month...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2016-10-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/ncomms13207 |
| _version_ | 1819202436826398720 |
|---|---|
| author | Thierry Jardé Bethan Lloyd-Lewis Mairian Thomas Howard Kendrick Lorenzo Melchor Lauriane Bougaret Peter D. Watson Kenneth Ewan Matthew J. Smalley Trevor C. Dale |
| author_facet | Thierry Jardé Bethan Lloyd-Lewis Mairian Thomas Howard Kendrick Lorenzo Melchor Lauriane Bougaret Peter D. Watson Kenneth Ewan Matthew J. Smalley Trevor C. Dale |
| author_sort | Thierry Jardé |
| collection | DOAJ |
| description | Three-dimensional culture systems and organoids for mammary glands are important to understand mammary gland development. Here, the authors identify conditions (including Neuregulin 1 and R-spondin 1) that allow the culture of organoids that are responsive to hormonal stimulation for up to 2.5 months. |
| first_indexed | 2024-12-23T04:04:00Z |
| format | Article |
| id | doaj.art-dd27b68633a7410fb89e10d4f7836659 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-23T04:04:00Z |
| publishDate | 2016-10-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-dd27b68633a7410fb89e10d4f78366592022-12-21T18:00:41ZengNature PortfolioNature Communications2041-17232016-10-017111410.1038/ncomms13207Wnt and Neuregulin1/ErbB signalling extends 3D culture of hormone responsive mammary organoidsThierry Jardé0Bethan Lloyd-Lewis1Mairian Thomas2Howard Kendrick3Lorenzo Melchor4Lauriane Bougaret5Peter D. Watson6Kenneth Ewan7Matthew J. Smalley8Trevor C. Dale9Cardiff School of Biosciences, Cardiff UniversityCardiff School of Biosciences, Cardiff UniversityCardiff School of Biosciences, Cardiff UniversityEuropean Cancer Stem Cell Research Institute, Cardiff School of Biosciences, Cardiff UniversityDivision of Breast Cancer Research, Breast Cancer Now, Institute of Cancer ResearchCardiff School of Biosciences, Cardiff UniversityCardiff School of Biosciences, Cardiff UniversityCardiff School of Biosciences, Cardiff UniversityEuropean Cancer Stem Cell Research Institute, Cardiff School of Biosciences, Cardiff UniversityCardiff School of Biosciences, Cardiff UniversityThree-dimensional culture systems and organoids for mammary glands are important to understand mammary gland development. Here, the authors identify conditions (including Neuregulin 1 and R-spondin 1) that allow the culture of organoids that are responsive to hormonal stimulation for up to 2.5 months.https://doi.org/10.1038/ncomms13207 |
| spellingShingle | Thierry Jardé Bethan Lloyd-Lewis Mairian Thomas Howard Kendrick Lorenzo Melchor Lauriane Bougaret Peter D. Watson Kenneth Ewan Matthew J. Smalley Trevor C. Dale Wnt and Neuregulin1/ErbB signalling extends 3D culture of hormone responsive mammary organoids Nature Communications |
| title | Wnt and Neuregulin1/ErbB signalling extends 3D culture of hormone responsive mammary organoids |
| title_full | Wnt and Neuregulin1/ErbB signalling extends 3D culture of hormone responsive mammary organoids |
| title_fullStr | Wnt and Neuregulin1/ErbB signalling extends 3D culture of hormone responsive mammary organoids |
| title_full_unstemmed | Wnt and Neuregulin1/ErbB signalling extends 3D culture of hormone responsive mammary organoids |
| title_short | Wnt and Neuregulin1/ErbB signalling extends 3D culture of hormone responsive mammary organoids |
| title_sort | wnt and neuregulin1 erbb signalling extends 3d culture of hormone responsive mammary organoids |
| url | https://doi.org/10.1038/ncomms13207 |
| work_keys_str_mv | AT thierryjarde wntandneuregulin1erbbsignallingextends3dcultureofhormoneresponsivemammaryorganoids AT bethanlloydlewis wntandneuregulin1erbbsignallingextends3dcultureofhormoneresponsivemammaryorganoids AT mairianthomas wntandneuregulin1erbbsignallingextends3dcultureofhormoneresponsivemammaryorganoids AT howardkendrick wntandneuregulin1erbbsignallingextends3dcultureofhormoneresponsivemammaryorganoids AT lorenzomelchor wntandneuregulin1erbbsignallingextends3dcultureofhormoneresponsivemammaryorganoids AT laurianebougaret wntandneuregulin1erbbsignallingextends3dcultureofhormoneresponsivemammaryorganoids AT peterdwatson wntandneuregulin1erbbsignallingextends3dcultureofhormoneresponsivemammaryorganoids AT kennethewan wntandneuregulin1erbbsignallingextends3dcultureofhormoneresponsivemammaryorganoids AT matthewjsmalley wntandneuregulin1erbbsignallingextends3dcultureofhormoneresponsivemammaryorganoids AT trevorcdale wntandneuregulin1erbbsignallingextends3dcultureofhormoneresponsivemammaryorganoids |