Sarcopenia in Patients With Parkinson's Disease: A Systematic Review and Meta-Analysis
Background: Parkinson's disease (PD) and sarcopenia are two common diseases in aging people. To date, the prevalence of sarcopenia in PD patients and the relationship between clinical features and sarcopenia in PD patients are not clear. The aim of the study was to (1) assess the prevalence of...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-03-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2021.598035/full |
| _version_ | 1819320495767552000 |
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| author | Yingying Cai Yingying Cai Fei Feng Qianqian Wei Zheng Jiang Ruwei Ou Huifang Shang |
| author_facet | Yingying Cai Yingying Cai Fei Feng Qianqian Wei Zheng Jiang Ruwei Ou Huifang Shang |
| author_sort | Yingying Cai |
| collection | DOAJ |
| description | Background: Parkinson's disease (PD) and sarcopenia are two common diseases in aging people. To date, the prevalence of sarcopenia in PD patients and the relationship between clinical features and sarcopenia in PD patients are not clear. The aim of the study was to (1) assess the prevalence of sarcopenia in PD patients and (2) reveal the clinical features between PD patients with and without sarcopenia.Method: A systematic review was carried out through screening PubMed, EMBASE, and Cochrane database in May 2020. All study designs (case–control, cohort, and cross-sectional studies) were eligible for meta-analysis. Data of patients' characteristics, sarcopenia criteria, sarcopenia prevalence, and sarcopenia measures were retrieved. The primary outcome was estimated prevalence of sarcopenia by a pooled prevalence (%) and its 95% confidence interval (CI), using a random-effects model. The secondary outcome was the differences in clinical features between PD patients with and without sarcopenia by meta-analysis. Included articles were assessed for risk of bias. Potential sources of variation were investigated by using subgroup analyses and meta-regression.Result: Ten studies were included in the review. Among them, nine were cross-sectional studies, and one was a prospective cohort study. Age of participants with PD in the studies ranged from 51.1 to 80.7 years. The estimated prevalence of sarcopenia ranged from 6 to 55.5%. The random-effects pooled prevalence was 29% (95% CIs: 0.18–0.40). When only studies at low risk of bias were considered, pooled prevalence decreased to 17% (95% CIs: 0.02–0.33), with still high heterogeneity. The incidence of falls in PD patients with sarcopenia was higher than that in PD patients without sarcopenia. There was no difference in sex ratio between PD patients with and without sarcopenia.Conclusion: Sarcopenia seems to be common in patients with PD. Early assessment of sarcopenia should be implemented in PD to avoid fall and disability. |
| first_indexed | 2024-12-24T11:20:30Z |
| format | Article |
| id | doaj.art-dd2a953243254b369db98aa7a61c6329 |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-12-24T11:20:30Z |
| publishDate | 2021-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-dd2a953243254b369db98aa7a61c63292022-12-21T16:58:16ZengFrontiers Media S.A.Frontiers in Neurology1664-22952021-03-011210.3389/fneur.2021.598035598035Sarcopenia in Patients With Parkinson's Disease: A Systematic Review and Meta-AnalysisYingying Cai0Yingying Cai1Fei Feng2Qianqian Wei3Zheng Jiang4Ruwei Ou5Huifang Shang6Laboratory of Neurodegenerative Disorders, Department of Neurology, West China Hospital, Sichuan University, Chengdu, ChinaDepartment of Geriatrics, Clinical Medical College and The First Affiliated Hospital of Chengdu Medical College, Chengdu, ChinaLaboratory of Neurodegenerative Disorders, Department of Neurology, West China Hospital, Sichuan University, Chengdu, ChinaLaboratory of Neurodegenerative Disorders, Department of Neurology, West China Hospital, Sichuan University, Chengdu, ChinaLaboratory of Neurodegenerative Disorders, Department of Neurology, West China Hospital, Sichuan University, Chengdu, ChinaLaboratory of Neurodegenerative Disorders, Department of Neurology, West China Hospital, Sichuan University, Chengdu, ChinaLaboratory of Neurodegenerative Disorders, Department of Neurology, West China Hospital, Sichuan University, Chengdu, ChinaBackground: Parkinson's disease (PD) and sarcopenia are two common diseases in aging people. To date, the prevalence of sarcopenia in PD patients and the relationship between clinical features and sarcopenia in PD patients are not clear. The aim of the study was to (1) assess the prevalence of sarcopenia in PD patients and (2) reveal the clinical features between PD patients with and without sarcopenia.Method: A systematic review was carried out through screening PubMed, EMBASE, and Cochrane database in May 2020. All study designs (case–control, cohort, and cross-sectional studies) were eligible for meta-analysis. Data of patients' characteristics, sarcopenia criteria, sarcopenia prevalence, and sarcopenia measures were retrieved. The primary outcome was estimated prevalence of sarcopenia by a pooled prevalence (%) and its 95% confidence interval (CI), using a random-effects model. The secondary outcome was the differences in clinical features between PD patients with and without sarcopenia by meta-analysis. Included articles were assessed for risk of bias. Potential sources of variation were investigated by using subgroup analyses and meta-regression.Result: Ten studies were included in the review. Among them, nine were cross-sectional studies, and one was a prospective cohort study. Age of participants with PD in the studies ranged from 51.1 to 80.7 years. The estimated prevalence of sarcopenia ranged from 6 to 55.5%. The random-effects pooled prevalence was 29% (95% CIs: 0.18–0.40). When only studies at low risk of bias were considered, pooled prevalence decreased to 17% (95% CIs: 0.02–0.33), with still high heterogeneity. The incidence of falls in PD patients with sarcopenia was higher than that in PD patients without sarcopenia. There was no difference in sex ratio between PD patients with and without sarcopenia.Conclusion: Sarcopenia seems to be common in patients with PD. Early assessment of sarcopenia should be implemented in PD to avoid fall and disability.https://www.frontiersin.org/articles/10.3389/fneur.2021.598035/fullsarcopeniaParkinson's diseasesystematic reviewmeta-analysisprevalencefall |
| spellingShingle | Yingying Cai Yingying Cai Fei Feng Qianqian Wei Zheng Jiang Ruwei Ou Huifang Shang Sarcopenia in Patients With Parkinson's Disease: A Systematic Review and Meta-Analysis Frontiers in Neurology sarcopenia Parkinson's disease systematic review meta-analysis prevalence fall |
| title | Sarcopenia in Patients With Parkinson's Disease: A Systematic Review and Meta-Analysis |
| title_full | Sarcopenia in Patients With Parkinson's Disease: A Systematic Review and Meta-Analysis |
| title_fullStr | Sarcopenia in Patients With Parkinson's Disease: A Systematic Review and Meta-Analysis |
| title_full_unstemmed | Sarcopenia in Patients With Parkinson's Disease: A Systematic Review and Meta-Analysis |
| title_short | Sarcopenia in Patients With Parkinson's Disease: A Systematic Review and Meta-Analysis |
| title_sort | sarcopenia in patients with parkinson s disease a systematic review and meta analysis |
| topic | sarcopenia Parkinson's disease systematic review meta-analysis prevalence fall |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2021.598035/full |
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