Correlation between the serum level of ferritin and D-dimer and the severity of COVID-19 infection
Abstract Background Many laboratory biomarkers were used for diagnosis of COVID-19 infection; however, their accuracy to assess the severity and prognosis are still to be evaluated. This study aims to correlate between the serum ferritin and D-dimer levels and the severity of COVID-19 infection and...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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SpringerOpen
2023-08-01
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| Series: | The Egyptian Journal of Bronchology |
| Online Access: | https://doi.org/10.1186/s43168-023-00218-1 |
| _version_ | 1827724160507314176 |
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| author | Eman Badawy AbdelFattah Ashraf Mokhtar Madkour Shimaa Mohamed I. Amer Noha Othman Ahmed |
| author_facet | Eman Badawy AbdelFattah Ashraf Mokhtar Madkour Shimaa Mohamed I. Amer Noha Othman Ahmed |
| author_sort | Eman Badawy AbdelFattah |
| collection | DOAJ |
| description | Abstract Background Many laboratory biomarkers were used for diagnosis of COVID-19 infection; however, their accuracy to assess the severity and prognosis are still to be evaluated. This study aims to correlate between the serum ferritin and D-dimer levels and the severity of COVID-19 infection and its outcome. Results Retrospective data retrieval of 150 confirmed COVID-19 infection patients admitted in Ain Shams University Specialized Hospital El Obour during period between April and July 2020 were studied. Ninety-six were survivors and 54 were non-survivors. The number of co-morbidities, the level of D-dimer and serum ferritin were correlated with ICU admission, need for mechanical ventilation and mortality with P value < 0.0001. Serum ferritin and D-dimer levels were significantly correlated with degree of HRCT chest severity with P value < 0.0001. The cut-off value of D-dimer for mortality was 700 ng/ml (sensitivity 83.33%, specificity 59.38%), and that for serum ferritin was 300 ng/ml (sensitivity 88.89%, specificity 58.33%), cut-off value of D-dimer for ICU admission was 863 ng/ml and that for serum ferritin was 300 ng/ml, cut-off value of D-dimer for mechanical ventilation was 700 ng/ml, and that for serum ferritin was 600 ng/ml. Conclusion D-dimer and serum ferritin are important biomarkers in predicting the mortality, ICU admission and need for mechanical ventilation in COVID-19 subjects. Thus helps in early detection of risk of progression and improving outcome. The current study also provides probable cut-off values for both biomarkers above which mortality, ICU admission, and mechanical ventilation need can be expected. Trial registration ClinicalTrials.gov ID: NCT0567281. Retrospectively registered. 4th January 2023. https://register.clinicaltrials.gov/prs/app/action/SelectProtocol?sid=S000CT6C&selectaction=Edit&uid=U00056R5&ts=2&cx=-tlu9xu . |
| first_indexed | 2024-03-10T22:10:45Z |
| format | Article |
| id | doaj.art-dd2bd18bee3048febf56d7c5c738b0c7 |
| institution | Directory Open Access Journal |
| issn | 2314-8551 |
| language | English |
| last_indexed | 2024-03-10T22:10:45Z |
| publishDate | 2023-08-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | The Egyptian Journal of Bronchology |
| spelling | doaj.art-dd2bd18bee3048febf56d7c5c738b0c72023-11-19T12:36:54ZengSpringerOpenThe Egyptian Journal of Bronchology2314-85512023-08-0117111110.1186/s43168-023-00218-1Correlation between the serum level of ferritin and D-dimer and the severity of COVID-19 infectionEman Badawy AbdelFattah0Ashraf Mokhtar Madkour1Shimaa Mohamed I. Amer2Noha Othman Ahmed3Chest Department, Faculty of Medicine, Ain Shams UniversityChest Department, Faculty of Medicine, Ain Shams UniversityChest Department, Faculty of Medicine, Ain Shams UniversityChest Department, Faculty of Medicine, Ain Shams UniversityAbstract Background Many laboratory biomarkers were used for diagnosis of COVID-19 infection; however, their accuracy to assess the severity and prognosis are still to be evaluated. This study aims to correlate between the serum ferritin and D-dimer levels and the severity of COVID-19 infection and its outcome. Results Retrospective data retrieval of 150 confirmed COVID-19 infection patients admitted in Ain Shams University Specialized Hospital El Obour during period between April and July 2020 were studied. Ninety-six were survivors and 54 were non-survivors. The number of co-morbidities, the level of D-dimer and serum ferritin were correlated with ICU admission, need for mechanical ventilation and mortality with P value < 0.0001. Serum ferritin and D-dimer levels were significantly correlated with degree of HRCT chest severity with P value < 0.0001. The cut-off value of D-dimer for mortality was 700 ng/ml (sensitivity 83.33%, specificity 59.38%), and that for serum ferritin was 300 ng/ml (sensitivity 88.89%, specificity 58.33%), cut-off value of D-dimer for ICU admission was 863 ng/ml and that for serum ferritin was 300 ng/ml, cut-off value of D-dimer for mechanical ventilation was 700 ng/ml, and that for serum ferritin was 600 ng/ml. Conclusion D-dimer and serum ferritin are important biomarkers in predicting the mortality, ICU admission and need for mechanical ventilation in COVID-19 subjects. Thus helps in early detection of risk of progression and improving outcome. The current study also provides probable cut-off values for both biomarkers above which mortality, ICU admission, and mechanical ventilation need can be expected. Trial registration ClinicalTrials.gov ID: NCT0567281. Retrospectively registered. 4th January 2023. https://register.clinicaltrials.gov/prs/app/action/SelectProtocol?sid=S000CT6C&selectaction=Edit&uid=U00056R5&ts=2&cx=-tlu9xu .https://doi.org/10.1186/s43168-023-00218-1 |
| spellingShingle | Eman Badawy AbdelFattah Ashraf Mokhtar Madkour Shimaa Mohamed I. Amer Noha Othman Ahmed Correlation between the serum level of ferritin and D-dimer and the severity of COVID-19 infection The Egyptian Journal of Bronchology |
| title | Correlation between the serum level of ferritin and D-dimer and the severity of COVID-19 infection |
| title_full | Correlation between the serum level of ferritin and D-dimer and the severity of COVID-19 infection |
| title_fullStr | Correlation between the serum level of ferritin and D-dimer and the severity of COVID-19 infection |
| title_full_unstemmed | Correlation between the serum level of ferritin and D-dimer and the severity of COVID-19 infection |
| title_short | Correlation between the serum level of ferritin and D-dimer and the severity of COVID-19 infection |
| title_sort | correlation between the serum level of ferritin and d dimer and the severity of covid 19 infection |
| url | https://doi.org/10.1186/s43168-023-00218-1 |
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