Systems modeling of molecular mechanisms controlling cytokine-driven CD4+ T cell differentiation and phenotype plasticity.

Systems modeling of molecular mechanisms controlling cytokine-driven CD4+ T cell differentiation and phenotype plasticity.

Differentiation of CD4+ T cells into effector or regulatory phenotypes is tightly controlled by the cytokine milieu, complex intracellular signaling networks and numerous transcriptional regulators. We combined experimental approaches and computational modeling to investigate the mechanisms controll...

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Bibliographic Details
Main Authors: Adria Carbo, Raquel Hontecillas, Barbara Kronsteiner, Monica Viladomiu, Mireia Pedragosa, Pinyi Lu, Casandra W Philipson, Stefan Hoops, Madhav Marathe, Stephen Eubank, Keith Bisset, Katherine Wendelsdorf, Abdul Jarrah, Yongguo Mei, Josep Bassaganya-Riera
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-04-01
Series:PLoS Computational Biology
Online Access:http://europepmc.org/articles/PMC3617204?pdf=render

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