Fecal microbiota transplant by push enteroscopy to treat diarrhea caused by Clostridium difficile
ABSTRACT Clostridium difficile is the major etiological agent of pseudomembranous colitis and is found in up to 20% of adult inpatients. The recommended treatment is antibiotic therapy with metronidazole and/or vancomycin. However, the recurrence rate may reach up to 25% and it increases in each epi...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Instituto Israelita de Ensino e Pesquisa Albert Einstein
|
| Series: | Einstein (São Paulo) |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082015000200031&lng=en&tlng=en |
| _version_ | 1818328523649056768 |
|---|---|
| author | Arnaldo José Ganc Ricardo Leite Ganc Sílvia Mansur Reimão Alberto Frisoli Junior Jacyr Pasternak |
| author_facet | Arnaldo José Ganc Ricardo Leite Ganc Sílvia Mansur Reimão Alberto Frisoli Junior Jacyr Pasternak |
| author_sort | Arnaldo José Ganc |
| collection | DOAJ |
| description | ABSTRACT Clostridium difficile is the major etiological agent of pseudomembranous colitis and is found in up to 20% of adult inpatients. The recommended treatment is antibiotic therapy with metronidazole and/or vancomycin. However, the recurrence rate may reach up to 25% and it increases in each episode. The newest alternative to treat diarrhea due to recurrent Clostridium difficile is fecal microbiota transplantation. The procedure was performed in 12 patients, with a 6-month follow-up on 10 of them. Of the ten cases, bacterial recurrence was diagnosed in only one patient, after a course of antibiotic to treat urinary tract infection, without presenting with diarrhea. The particularity of our study, besides being an unprecedented event in South America, is the way to perform the infusion of fecal microbiota by enteroscopy. |
| first_indexed | 2024-12-13T12:33:31Z |
| format | Article |
| id | doaj.art-dd2c9db09ae9482d9489407fbfa185de |
| institution | Directory Open Access Journal |
| issn | 2317-6385 |
| language | English |
| last_indexed | 2024-12-13T12:33:31Z |
| publisher | Instituto Israelita de Ensino e Pesquisa Albert Einstein |
| record_format | Article |
| series | Einstein (São Paulo) |
| spelling | doaj.art-dd2c9db09ae9482d9489407fbfa185de2022-12-21T23:45:57ZengInstituto Israelita de Ensino e Pesquisa Albert EinsteinEinstein (São Paulo)2317-638513233833910.1590/S1679-45082015MD3106S1679-45082015000200031Fecal microbiota transplant by push enteroscopy to treat diarrhea caused by Clostridium difficileArnaldo José GancRicardo Leite GancSílvia Mansur ReimãoAlberto Frisoli JuniorJacyr PasternakABSTRACT Clostridium difficile is the major etiological agent of pseudomembranous colitis and is found in up to 20% of adult inpatients. The recommended treatment is antibiotic therapy with metronidazole and/or vancomycin. However, the recurrence rate may reach up to 25% and it increases in each episode. The newest alternative to treat diarrhea due to recurrent Clostridium difficile is fecal microbiota transplantation. The procedure was performed in 12 patients, with a 6-month follow-up on 10 of them. Of the ten cases, bacterial recurrence was diagnosed in only one patient, after a course of antibiotic to treat urinary tract infection, without presenting with diarrhea. The particularity of our study, besides being an unprecedented event in South America, is the way to perform the infusion of fecal microbiota by enteroscopy.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082015000200031&lng=en&tlng=enClostridium difficileTransplante homólogoEnterocolite pseudomembranosa/etiologiaEndoscopia/métodosDiarreia/quimioterapiaMetronidazol/uso terapêuticoVancomicina/uso terapêutico |
| spellingShingle | Arnaldo José Ganc Ricardo Leite Ganc Sílvia Mansur Reimão Alberto Frisoli Junior Jacyr Pasternak Fecal microbiota transplant by push enteroscopy to treat diarrhea caused by Clostridium difficile Einstein (São Paulo) Clostridium difficile Transplante homólogo Enterocolite pseudomembranosa/etiologia Endoscopia/métodos Diarreia/quimioterapia Metronidazol/uso terapêutico Vancomicina/uso terapêutico |
| title | Fecal microbiota transplant by push enteroscopy to treat diarrhea caused by Clostridium difficile |
| title_full | Fecal microbiota transplant by push enteroscopy to treat diarrhea caused by Clostridium difficile |
| title_fullStr | Fecal microbiota transplant by push enteroscopy to treat diarrhea caused by Clostridium difficile |
| title_full_unstemmed | Fecal microbiota transplant by push enteroscopy to treat diarrhea caused by Clostridium difficile |
| title_short | Fecal microbiota transplant by push enteroscopy to treat diarrhea caused by Clostridium difficile |
| title_sort | fecal microbiota transplant by push enteroscopy to treat diarrhea caused by clostridium difficile |
| topic | Clostridium difficile Transplante homólogo Enterocolite pseudomembranosa/etiologia Endoscopia/métodos Diarreia/quimioterapia Metronidazol/uso terapêutico Vancomicina/uso terapêutico |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082015000200031&lng=en&tlng=en |
| work_keys_str_mv | AT arnaldojoseganc fecalmicrobiotatransplantbypushenteroscopytotreatdiarrheacausedbyclostridiumdifficile AT ricardoleiteganc fecalmicrobiotatransplantbypushenteroscopytotreatdiarrheacausedbyclostridiumdifficile AT silviamansurreimao fecalmicrobiotatransplantbypushenteroscopytotreatdiarrheacausedbyclostridiumdifficile AT albertofrisolijunior fecalmicrobiotatransplantbypushenteroscopytotreatdiarrheacausedbyclostridiumdifficile AT jacyrpasternak fecalmicrobiotatransplantbypushenteroscopytotreatdiarrheacausedbyclostridiumdifficile |