Use of HT-29 Cell Line to Investigate Toxicological Effects of Mycotoxins: a Mini Review
HT-29 is the human colon adenocarcinoma cell line mostly used to study human colon cancers. Because of its ability to resemble mature intestinal cells, its use is wide. HT-29 cell line is a suitable in vitro model for intestinal cells to monitor the toxicity of mycotoxins, because these cells corres...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Agroprint Timisoara
2023-09-01
|
| Series: | Scientific Papers Animal Science and Biotechnologies |
| Subjects: | |
| Online Access: | https://spasb.ro/index.php/public_html/article/view/775 |
| _version_ | 1827288094655643648 |
|---|---|
| author | Rudolf Dupak Ivana Spevakova Marcela Capcarova |
| author_facet | Rudolf Dupak Ivana Spevakova Marcela Capcarova |
| author_sort | Rudolf Dupak |
| collection | DOAJ |
| description | HT-29 is the human colon adenocarcinoma cell line mostly used to study human colon cancers. Because of its ability to resemble mature intestinal cells, its use is wide. HT-29 cell line is a suitable in vitro model for intestinal cells to monitor the toxicity of mycotoxins, because these cells correspond to one of the main organs of action of mycotoxins. The main studied parameters of the effects of mycotoxins on HT-29 cell line include cell viability, cell apoptosis or necrosis, oxidative damage, immunotoxicity and macromolecule synthesis. In this review we provide an introduction to HT-29 cell line and its use for research of toxicological effects of mycotoxins, which represents an important food contaminant. |
| first_indexed | 2024-04-24T11:24:01Z |
| format | Article |
| id | doaj.art-dd2d2160b3724ffe8553e4148336664f |
| institution | Directory Open Access Journal |
| issn | 1841-9364 2344-4576 |
| language | English |
| last_indexed | 2024-04-24T11:24:01Z |
| publishDate | 2023-09-01 |
| publisher | Agroprint Timisoara |
| record_format | Article |
| series | Scientific Papers Animal Science and Biotechnologies |
| spelling | doaj.art-dd2d2160b3724ffe8553e4148336664f2024-04-11T04:01:40ZengAgroprint TimisoaraScientific Papers Animal Science and Biotechnologies1841-93642344-45762023-09-01532160160775Use of HT-29 Cell Line to Investigate Toxicological Effects of Mycotoxins: a Mini ReviewRudolf Dupak0Ivana Spevakova1Marcela Capcarova2Slovak University of Agriculture in Nitra, Department of Animal Physiology, Faculty of Biotechnology and Food Sciences, Tr. A. Hlinku 2, 949 76 Nitra, SlovakiaSlovak University of Agriculture in Nitra, Department of Animal Physiology, Faculty of Biotechnology and Food Sciences, Tr. A. Hlinku 2, 949 76 Nitra, SlovakiaSlovak University of Agriculture in Nitra, Department of Animal Physiology, Faculty of Biotechnology and Food Sciences, Tr. A. Hlinku 2, 949 76 Nitra, SlovakiaHT-29 is the human colon adenocarcinoma cell line mostly used to study human colon cancers. Because of its ability to resemble mature intestinal cells, its use is wide. HT-29 cell line is a suitable in vitro model for intestinal cells to monitor the toxicity of mycotoxins, because these cells correspond to one of the main organs of action of mycotoxins. The main studied parameters of the effects of mycotoxins on HT-29 cell line include cell viability, cell apoptosis or necrosis, oxidative damage, immunotoxicity and macromolecule synthesis. In this review we provide an introduction to HT-29 cell line and its use for research of toxicological effects of mycotoxins, which represents an important food contaminant.https://spasb.ro/index.php/public_html/article/view/775cell viabilityht-29mycotoxinsoxidative stress |
| spellingShingle | Rudolf Dupak Ivana Spevakova Marcela Capcarova Use of HT-29 Cell Line to Investigate Toxicological Effects of Mycotoxins: a Mini Review Scientific Papers Animal Science and Biotechnologies cell viability ht-29 mycotoxins oxidative stress |
| title | Use of HT-29 Cell Line to Investigate Toxicological Effects of Mycotoxins: a Mini Review |
| title_full | Use of HT-29 Cell Line to Investigate Toxicological Effects of Mycotoxins: a Mini Review |
| title_fullStr | Use of HT-29 Cell Line to Investigate Toxicological Effects of Mycotoxins: a Mini Review |
| title_full_unstemmed | Use of HT-29 Cell Line to Investigate Toxicological Effects of Mycotoxins: a Mini Review |
| title_short | Use of HT-29 Cell Line to Investigate Toxicological Effects of Mycotoxins: a Mini Review |
| title_sort | use of ht 29 cell line to investigate toxicological effects of mycotoxins a mini review |
| topic | cell viability ht-29 mycotoxins oxidative stress |
| url | https://spasb.ro/index.php/public_html/article/view/775 |
| work_keys_str_mv | AT rudolfdupak useofht29celllinetoinvestigatetoxicologicaleffectsofmycotoxinsaminireview AT ivanaspevakova useofht29celllinetoinvestigatetoxicologicaleffectsofmycotoxinsaminireview AT marcelacapcarova useofht29celllinetoinvestigatetoxicologicaleffectsofmycotoxinsaminireview |