Improved Short-Term Outcomes of Osteochondral Lesions of the Knee Following Arthroscopic Treatment With Bone Marrow Aspirate Concentrate and Cartilage-Derived Matrix
Purpose: To assess the postoperative objective, subjective, and functional outcomes as well as complication rates in osteochondral defect patients treated with bone marrow aspirate concentrate (BMAC) and cartilage-derived matrix (CDM) during knee arthroscopy. Methods: A retrospective chart review wa...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2021-04-01
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| Series: | Arthroscopy, Sports Medicine, and Rehabilitation |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666061X20301759 |
| _version_ | 1818893209849298944 |
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| author | Iciar M. Dávila Castrodad, M.D. Erica S. Simone, M.S., A.T.C., O.T.C. Jennifer Kurowicki, M.D. Justin X. Melendez, B.S. Samuel J. Mease, M.D. Vincent K. McInerney, M.D. Anthony J. Scillia, M.D. |
| author_facet | Iciar M. Dávila Castrodad, M.D. Erica S. Simone, M.S., A.T.C., O.T.C. Jennifer Kurowicki, M.D. Justin X. Melendez, B.S. Samuel J. Mease, M.D. Vincent K. McInerney, M.D. Anthony J. Scillia, M.D. |
| author_sort | Iciar M. Dávila Castrodad, M.D. |
| collection | DOAJ |
| description | Purpose: To assess the postoperative objective, subjective, and functional outcomes as well as complication rates in osteochondral defect patients treated with bone marrow aspirate concentrate (BMAC) and cartilage-derived matrix (CDM) during knee arthroscopy. Methods: A retrospective chart review was performed for patients treated arthroscopically with BMAC and CDM between August 2015 and August 2018 and had more than 1-year follow-up. Demographic factors such as age, sex, body mass index, and comorbidities were collected for all patients. Size and location of the osteochondral lesions also were documented. Results: A total of 14 patients were identified with a mean follow-up of 19 months. On average, patients were 34 years of age (range 16-58 years) and 43% were female. Postoperatively, knee flexion increased by 8° from 124° to 132° (P = .002). All patients regained full extension; however, 1 patient later acquired a 2° extension contracture after a traumatic event. The average hamstring strength significantly increased from 4.1 to 4.6 postoperatively (P = .33). The average quadriceps strength significantly increased from 4.0 to 4.5 postoperatively (P = .007). Mean visual analog scale scores significantly decreased postoperatively (4.5 vs 1.4; P = .001). There was a significant increase in Knee Outcome Survey Activities of Daily Living scores (53.8 vs 92.9; P = .007). Mean Knee Outcome Survey-Sports scores also increased, although this was nonsignificant (28.2 vs 79.5; P = .560). No significant differences were noted in pain and functional outcomes when stratified by the osteochondral defect size and location. Complications included a stitch abscess, Baker’s cyst, and residual pain treated with hyaluronic acid injection. Conclusions: This study demonstrated arthroscopic BMAC and CDM implantation appears to be safe and has the potential to improve patient outcomes in the short-term postoperative period. Level of Evidence: IV, therapeutic case series. |
| first_indexed | 2024-12-19T18:08:58Z |
| format | Article |
| id | doaj.art-dd2eefd4b1c24322af5ba11d4f2528e3 |
| institution | Directory Open Access Journal |
| issn | 2666-061X |
| language | English |
| last_indexed | 2024-12-19T18:08:58Z |
| publishDate | 2021-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Arthroscopy, Sports Medicine, and Rehabilitation |
| spelling | doaj.art-dd2eefd4b1c24322af5ba11d4f2528e32022-12-21T20:11:22ZengElsevierArthroscopy, Sports Medicine, and Rehabilitation2666-061X2021-04-0132e477e484Improved Short-Term Outcomes of Osteochondral Lesions of the Knee Following Arthroscopic Treatment With Bone Marrow Aspirate Concentrate and Cartilage-Derived MatrixIciar M. Dávila Castrodad, M.D.0Erica S. Simone, M.S., A.T.C., O.T.C.1Jennifer Kurowicki, M.D.2Justin X. Melendez, B.S.3Samuel J. Mease, M.D.4Vincent K. McInerney, M.D.5Anthony J. Scillia, M.D.6Department of Orthopaedic Surgery, St. Joseph’s University Medical Center, Paterson, New Jersey, U.S.A.; New Jersey Orthopaedic Institute, Wayne, New Jersey, U.S.A.New Jersey Orthopaedic Institute, Wayne, New Jersey, U.S.A.Department of Orthopaedic Surgery, St. Joseph’s University Medical Center, Paterson, New Jersey, U.S.A.New Jersey Orthopaedic Institute, Wayne, New Jersey, U.S.A.Department of Orthopaedic Surgery, St. Joseph’s University Medical Center, Paterson, New Jersey, U.S.A.Department of Orthopaedic Surgery, St. Joseph’s University Medical Center, Paterson, New Jersey, U.S.A.; New Jersey Orthopaedic Institute, Wayne, New Jersey, U.S.A.; Department of Orthopaedic Surgery, Hackensack Meridian School of Medicine at Seton Hall University, Nutley, New Jersey, U.S.ADepartment of Orthopaedic Surgery, St. Joseph’s University Medical Center, Paterson, New Jersey, U.S.A.; New Jersey Orthopaedic Institute, Wayne, New Jersey, U.S.A.; Department of Orthopaedic Surgery, Hackensack Meridian School of Medicine at Seton Hall University, Nutley, New Jersey, U.S.A; Address correspondence to Anthony J. Scillia, M.D., St. Joseph’s University Medical Center, Hackensack Meridian School of Medicine at Seton Hall University, Department of Orthopaedic Surgery, 703 Main St., Paterson, NJ 07503.Purpose: To assess the postoperative objective, subjective, and functional outcomes as well as complication rates in osteochondral defect patients treated with bone marrow aspirate concentrate (BMAC) and cartilage-derived matrix (CDM) during knee arthroscopy. Methods: A retrospective chart review was performed for patients treated arthroscopically with BMAC and CDM between August 2015 and August 2018 and had more than 1-year follow-up. Demographic factors such as age, sex, body mass index, and comorbidities were collected for all patients. Size and location of the osteochondral lesions also were documented. Results: A total of 14 patients were identified with a mean follow-up of 19 months. On average, patients were 34 years of age (range 16-58 years) and 43% were female. Postoperatively, knee flexion increased by 8° from 124° to 132° (P = .002). All patients regained full extension; however, 1 patient later acquired a 2° extension contracture after a traumatic event. The average hamstring strength significantly increased from 4.1 to 4.6 postoperatively (P = .33). The average quadriceps strength significantly increased from 4.0 to 4.5 postoperatively (P = .007). Mean visual analog scale scores significantly decreased postoperatively (4.5 vs 1.4; P = .001). There was a significant increase in Knee Outcome Survey Activities of Daily Living scores (53.8 vs 92.9; P = .007). Mean Knee Outcome Survey-Sports scores also increased, although this was nonsignificant (28.2 vs 79.5; P = .560). No significant differences were noted in pain and functional outcomes when stratified by the osteochondral defect size and location. Complications included a stitch abscess, Baker’s cyst, and residual pain treated with hyaluronic acid injection. Conclusions: This study demonstrated arthroscopic BMAC and CDM implantation appears to be safe and has the potential to improve patient outcomes in the short-term postoperative period. Level of Evidence: IV, therapeutic case series.http://www.sciencedirect.com/science/article/pii/S2666061X20301759 |
| spellingShingle | Iciar M. Dávila Castrodad, M.D. Erica S. Simone, M.S., A.T.C., O.T.C. Jennifer Kurowicki, M.D. Justin X. Melendez, B.S. Samuel J. Mease, M.D. Vincent K. McInerney, M.D. Anthony J. Scillia, M.D. Improved Short-Term Outcomes of Osteochondral Lesions of the Knee Following Arthroscopic Treatment With Bone Marrow Aspirate Concentrate and Cartilage-Derived Matrix Arthroscopy, Sports Medicine, and Rehabilitation |
| title | Improved Short-Term Outcomes of Osteochondral Lesions of the Knee Following Arthroscopic Treatment With Bone Marrow Aspirate Concentrate and Cartilage-Derived Matrix |
| title_full | Improved Short-Term Outcomes of Osteochondral Lesions of the Knee Following Arthroscopic Treatment With Bone Marrow Aspirate Concentrate and Cartilage-Derived Matrix |
| title_fullStr | Improved Short-Term Outcomes of Osteochondral Lesions of the Knee Following Arthroscopic Treatment With Bone Marrow Aspirate Concentrate and Cartilage-Derived Matrix |
| title_full_unstemmed | Improved Short-Term Outcomes of Osteochondral Lesions of the Knee Following Arthroscopic Treatment With Bone Marrow Aspirate Concentrate and Cartilage-Derived Matrix |
| title_short | Improved Short-Term Outcomes of Osteochondral Lesions of the Knee Following Arthroscopic Treatment With Bone Marrow Aspirate Concentrate and Cartilage-Derived Matrix |
| title_sort | improved short term outcomes of osteochondral lesions of the knee following arthroscopic treatment with bone marrow aspirate concentrate and cartilage derived matrix |
| url | http://www.sciencedirect.com/science/article/pii/S2666061X20301759 |
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