Genomic characterization of the human mitochondrial tumor suppressor gene 1 (<it>MTUS1</it>): 5' cloning and preliminary analysis of the multiple gene promoters
<p>Abstract</p> <p>Background</p> <p>Mitochondrial tumor suppressor gene 1 (<it>MTUS1</it>) has been recently identified as a candidate tumor suppressor gene which resides in a genomic region (8p22) that shows frequent loss of heterozygosity (LOH) in several...
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| Format: | Article |
| Language: | English |
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BMC
2009-06-01
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| Series: | BMC Research Notes |
| Online Access: | http://www.biomedcentral.com/1756-0500/2/109 |
| _version_ | 1818758858529570816 |
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| author | Ye Hui Liu Xiqiang Yu Jinsheng Zhou Xiaofeng |
| author_facet | Ye Hui Liu Xiqiang Yu Jinsheng Zhou Xiaofeng |
| author_sort | Ye Hui |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Mitochondrial tumor suppressor gene 1 (<it>MTUS1</it>) has been recently identified as a candidate tumor suppressor gene which resides in a genomic region (8p22) that shows frequent loss of heterozygosity (LOH) in several tumor types. It has been suggested that multiple gene promoters and alternative splicing lead to the expression of 5 known <it>MTUS1 </it>transcript variants.</p> <p>Findings</p> <p>Here, we characterized the 5' untranslated regions of the different transcript variants. We also cloned and functionally tested the alternatively utilized gene promoters that contribute to the production of different <it>MTUS1 </it>transcript variants.</p> <p>Conclusion</p> <p>Our results confirmed the early hypothesis that the transcript variants of <it>MTUS1 </it>gene are driven by multiple gene promoters.</p> |
| first_indexed | 2024-12-18T06:33:31Z |
| format | Article |
| id | doaj.art-dd302e9c17574d9a804aeeee0743c510 |
| institution | Directory Open Access Journal |
| issn | 1756-0500 |
| language | English |
| last_indexed | 2024-12-18T06:33:31Z |
| publishDate | 2009-06-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Research Notes |
| spelling | doaj.art-dd302e9c17574d9a804aeeee0743c5102022-12-21T21:17:50ZengBMCBMC Research Notes1756-05002009-06-012110910.1186/1756-0500-2-109Genomic characterization of the human mitochondrial tumor suppressor gene 1 (<it>MTUS1</it>): 5' cloning and preliminary analysis of the multiple gene promotersYe HuiLiu XiqiangYu JinshengZhou Xiaofeng<p>Abstract</p> <p>Background</p> <p>Mitochondrial tumor suppressor gene 1 (<it>MTUS1</it>) has been recently identified as a candidate tumor suppressor gene which resides in a genomic region (8p22) that shows frequent loss of heterozygosity (LOH) in several tumor types. It has been suggested that multiple gene promoters and alternative splicing lead to the expression of 5 known <it>MTUS1 </it>transcript variants.</p> <p>Findings</p> <p>Here, we characterized the 5' untranslated regions of the different transcript variants. We also cloned and functionally tested the alternatively utilized gene promoters that contribute to the production of different <it>MTUS1 </it>transcript variants.</p> <p>Conclusion</p> <p>Our results confirmed the early hypothesis that the transcript variants of <it>MTUS1 </it>gene are driven by multiple gene promoters.</p>http://www.biomedcentral.com/1756-0500/2/109 |
| spellingShingle | Ye Hui Liu Xiqiang Yu Jinsheng Zhou Xiaofeng Genomic characterization of the human mitochondrial tumor suppressor gene 1 (<it>MTUS1</it>): 5' cloning and preliminary analysis of the multiple gene promoters BMC Research Notes |
| title | Genomic characterization of the human mitochondrial tumor suppressor gene 1 (<it>MTUS1</it>): 5' cloning and preliminary analysis of the multiple gene promoters |
| title_full | Genomic characterization of the human mitochondrial tumor suppressor gene 1 (<it>MTUS1</it>): 5' cloning and preliminary analysis of the multiple gene promoters |
| title_fullStr | Genomic characterization of the human mitochondrial tumor suppressor gene 1 (<it>MTUS1</it>): 5' cloning and preliminary analysis of the multiple gene promoters |
| title_full_unstemmed | Genomic characterization of the human mitochondrial tumor suppressor gene 1 (<it>MTUS1</it>): 5' cloning and preliminary analysis of the multiple gene promoters |
| title_short | Genomic characterization of the human mitochondrial tumor suppressor gene 1 (<it>MTUS1</it>): 5' cloning and preliminary analysis of the multiple gene promoters |
| title_sort | genomic characterization of the human mitochondrial tumor suppressor gene 1 it mtus1 it 5 cloning and preliminary analysis of the multiple gene promoters |
| url | http://www.biomedcentral.com/1756-0500/2/109 |
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