The encapsulation effect of UV molecular absorbers into biocompatible lipid nanoparticles
<p>Abstract</p> <p>The efficiency of a cosmetic product depends not only on the active ingredients, but also on the carrier system devoted to improve its bioavailability. This article aims to encapsulate two couples of UV molecular absorbers, with a blocking action on both UV-A and...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
SpringerOpen
2011-01-01
|
| Series: | Nanoscale Research Letters |
| Online Access: | http://www.nanoscalereslett.com/content/6/1/73 |
| _version_ | 1797721603285450752 |
|---|---|
| author | Lacatusu Ioana Badea Nicoleta Murariu Alina Meghea Aurelia |
| author_facet | Lacatusu Ioana Badea Nicoleta Murariu Alina Meghea Aurelia |
| author_sort | Lacatusu Ioana |
| collection | DOAJ |
| description | <p>Abstract</p> <p>The efficiency of a cosmetic product depends not only on the active ingredients, but also on the carrier system devoted to improve its bioavailability. This article aims to encapsulate two couples of UV molecular absorbers, with a blocking action on both UV-A and UV-B domains, into efficient lipid nanoparticles. The effect of encapsulation on the specific properties such as sun protection factor and photostability behaviour has been demonstrated. The lipid nanoparticles with size range 30-350 nm and a polydispersity index between 0.217 and 0.244 are obtained using a modified high shear homogenisation method. The nanoparticles had spherical shapes with a single crystallisation form of lipid matrices characteristic for the least ordered crystal structure (α-form). The <it>in vitro </it>determination of photoprotection has led to high SPF ratings, with values of about 20, which assure a good photoprotection and filtering about 95% of UV radiation. The photoprotection effect after irradiation stage was observed to be increased more than twice compared to initial samples as a result of isomerisation phenomena. All the results have shown that good photoprotection effect and improved photostability could be obtained using such sunscreen couples, thus demonstrating that UV absorbers-solid lipid nanoparticles are promising carriers for cosmetic formulations.</p> |
| first_indexed | 2024-03-12T09:35:31Z |
| format | Article |
| id | doaj.art-dd308b39136b4a4b87765a709e470d17 |
| institution | Directory Open Access Journal |
| issn | 1931-7573 1556-276X |
| language | English |
| last_indexed | 2024-03-12T09:35:31Z |
| publishDate | 2011-01-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Nanoscale Research Letters |
| spelling | doaj.art-dd308b39136b4a4b87765a709e470d172023-09-02T13:41:55ZengSpringerOpenNanoscale Research Letters1931-75731556-276X2011-01-016173The encapsulation effect of UV molecular absorbers into biocompatible lipid nanoparticlesLacatusu IoanaBadea NicoletaMurariu AlinaMeghea Aurelia<p>Abstract</p> <p>The efficiency of a cosmetic product depends not only on the active ingredients, but also on the carrier system devoted to improve its bioavailability. This article aims to encapsulate two couples of UV molecular absorbers, with a blocking action on both UV-A and UV-B domains, into efficient lipid nanoparticles. The effect of encapsulation on the specific properties such as sun protection factor and photostability behaviour has been demonstrated. The lipid nanoparticles with size range 30-350 nm and a polydispersity index between 0.217 and 0.244 are obtained using a modified high shear homogenisation method. The nanoparticles had spherical shapes with a single crystallisation form of lipid matrices characteristic for the least ordered crystal structure (α-form). The <it>in vitro </it>determination of photoprotection has led to high SPF ratings, with values of about 20, which assure a good photoprotection and filtering about 95% of UV radiation. The photoprotection effect after irradiation stage was observed to be increased more than twice compared to initial samples as a result of isomerisation phenomena. All the results have shown that good photoprotection effect and improved photostability could be obtained using such sunscreen couples, thus demonstrating that UV absorbers-solid lipid nanoparticles are promising carriers for cosmetic formulations.</p>http://www.nanoscalereslett.com/content/6/1/73 |
| spellingShingle | Lacatusu Ioana Badea Nicoleta Murariu Alina Meghea Aurelia The encapsulation effect of UV molecular absorbers into biocompatible lipid nanoparticles Nanoscale Research Letters |
| title | The encapsulation effect of UV molecular absorbers into biocompatible lipid nanoparticles |
| title_full | The encapsulation effect of UV molecular absorbers into biocompatible lipid nanoparticles |
| title_fullStr | The encapsulation effect of UV molecular absorbers into biocompatible lipid nanoparticles |
| title_full_unstemmed | The encapsulation effect of UV molecular absorbers into biocompatible lipid nanoparticles |
| title_short | The encapsulation effect of UV molecular absorbers into biocompatible lipid nanoparticles |
| title_sort | encapsulation effect of uv molecular absorbers into biocompatible lipid nanoparticles |
| url | http://www.nanoscalereslett.com/content/6/1/73 |
| work_keys_str_mv | AT lacatusuioana theencapsulationeffectofuvmolecularabsorbersintobiocompatiblelipidnanoparticles AT badeanicoleta theencapsulationeffectofuvmolecularabsorbersintobiocompatiblelipidnanoparticles AT murariualina theencapsulationeffectofuvmolecularabsorbersintobiocompatiblelipidnanoparticles AT megheaaurelia theencapsulationeffectofuvmolecularabsorbersintobiocompatiblelipidnanoparticles AT lacatusuioana encapsulationeffectofuvmolecularabsorbersintobiocompatiblelipidnanoparticles AT badeanicoleta encapsulationeffectofuvmolecularabsorbersintobiocompatiblelipidnanoparticles AT murariualina encapsulationeffectofuvmolecularabsorbersintobiocompatiblelipidnanoparticles AT megheaaurelia encapsulationeffectofuvmolecularabsorbersintobiocompatiblelipidnanoparticles |