A target repurposing approach identifies N-myristoyltransferase as a new candidate drug target in filarial nematodes.
Myristoylation is a lipid modification involving the addition of a 14-carbon unsaturated fatty acid, myristic acid, to the N-terminal glycine of a subset of proteins, a modification that promotes their binding to cell membranes for varied biological functions. The process is catalyzed by myristoyl-C...
| Main Authors: | , , , , , , , |
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| 格式: | 文件 |
| 语言: | English |
| 出版: |
Public Library of Science (PLoS)
2014-09-01
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| 丛编: | PLoS Neglected Tropical Diseases |
| 在线阅读: | http://europepmc.org/articles/PMC4154664?pdf=render |