β-Cell Replacement Strategies: The Increasing Need for a “β-Cell Dogma”
Type 1 diabetes is an auto-immune disease resulting in the loss of pancreatic β-cells and, consequently, in chronic hyperglycemia. Insulin supplementation allows diabetic patients to control their glycaemia quite efficiently, but treated patients still display an overall shortened life expectancy an...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2017-06-01
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| Series: | Frontiers in Genetics |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/article/10.3389/fgene.2017.00075/full |
| _version_ | 1818419040288243712 |
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| author | Andhira Vieira Noémie Druelle Fabio Avolio Tiziana Napolitano Sergi Navarro-Sanz Serena Silvano Patrick Collombat |
| author_facet | Andhira Vieira Noémie Druelle Fabio Avolio Tiziana Napolitano Sergi Navarro-Sanz Serena Silvano Patrick Collombat |
| author_sort | Andhira Vieira |
| collection | DOAJ |
| description | Type 1 diabetes is an auto-immune disease resulting in the loss of pancreatic β-cells and, consequently, in chronic hyperglycemia. Insulin supplementation allows diabetic patients to control their glycaemia quite efficiently, but treated patients still display an overall shortened life expectancy and an altered quality of life as compared to their healthy counterparts. In this context and due to the ever increasing number of diabetics, establishing alternative therapies has become a crucial research goal. Most current efforts therefore aim at generating fully functional insulin-secreting β-like cells using multiple approaches. In this review, we screened the literature published since 2011 and inventoried the selected markers used to characterize insulin-secreting cells generated by in vitro differentiation of stem/precursor cells or by means of in vivo transdifferentiation. By listing these features, we noted important discrepancies when comparing the different approaches for the initial characterization of insulin-producing cells as true β-cells. Considering the recent advances achieved in this field of research, the necessity to establish strict guidelines has become a subject of crucial importance, especially should one contemplate the next step, which is the transplantation of in vitro or ex vivo generated insulin-secreting cells in type 1 diabetic patients. |
| first_indexed | 2024-12-14T12:32:15Z |
| format | Article |
| id | doaj.art-dd386b7f45c14b0eabcb0355c7aa5ef8 |
| institution | Directory Open Access Journal |
| issn | 1664-8021 |
| language | English |
| last_indexed | 2024-12-14T12:32:15Z |
| publishDate | 2017-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Genetics |
| spelling | doaj.art-dd386b7f45c14b0eabcb0355c7aa5ef82022-12-21T23:01:10ZengFrontiers Media S.A.Frontiers in Genetics1664-80212017-06-01810.3389/fgene.2017.00075237279β-Cell Replacement Strategies: The Increasing Need for a “β-Cell Dogma”Andhira VieiraNoémie DruelleFabio AvolioTiziana NapolitanoSergi Navarro-SanzSerena SilvanoPatrick CollombatType 1 diabetes is an auto-immune disease resulting in the loss of pancreatic β-cells and, consequently, in chronic hyperglycemia. Insulin supplementation allows diabetic patients to control their glycaemia quite efficiently, but treated patients still display an overall shortened life expectancy and an altered quality of life as compared to their healthy counterparts. In this context and due to the ever increasing number of diabetics, establishing alternative therapies has become a crucial research goal. Most current efforts therefore aim at generating fully functional insulin-secreting β-like cells using multiple approaches. In this review, we screened the literature published since 2011 and inventoried the selected markers used to characterize insulin-secreting cells generated by in vitro differentiation of stem/precursor cells or by means of in vivo transdifferentiation. By listing these features, we noted important discrepancies when comparing the different approaches for the initial characterization of insulin-producing cells as true β-cells. Considering the recent advances achieved in this field of research, the necessity to establish strict guidelines has become a subject of crucial importance, especially should one contemplate the next step, which is the transplantation of in vitro or ex vivo generated insulin-secreting cells in type 1 diabetic patients.http://journal.frontiersin.org/article/10.3389/fgene.2017.00075/fullβ-cellsdifferentiationstem cellstype 1 diabetesβ-cell markers |
| spellingShingle | Andhira Vieira Noémie Druelle Fabio Avolio Tiziana Napolitano Sergi Navarro-Sanz Serena Silvano Patrick Collombat β-Cell Replacement Strategies: The Increasing Need for a “β-Cell Dogma” Frontiers in Genetics β-cells differentiation stem cells type 1 diabetes β-cell markers |
| title | β-Cell Replacement Strategies: The Increasing Need for a “β-Cell Dogma” |
| title_full | β-Cell Replacement Strategies: The Increasing Need for a “β-Cell Dogma” |
| title_fullStr | β-Cell Replacement Strategies: The Increasing Need for a “β-Cell Dogma” |
| title_full_unstemmed | β-Cell Replacement Strategies: The Increasing Need for a “β-Cell Dogma” |
| title_short | β-Cell Replacement Strategies: The Increasing Need for a “β-Cell Dogma” |
| title_sort | β cell replacement strategies the increasing need for a β cell dogma |
| topic | β-cells differentiation stem cells type 1 diabetes β-cell markers |
| url | http://journal.frontiersin.org/article/10.3389/fgene.2017.00075/full |
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