Understanding the Hsp90 <i>N</i>-Terminal Dynamics: Structural and Molecular Insights into the Therapeutic Activities of Anticancer Inhibitors Radicicol (RD) and Radicicol Derivative (NVP-YUA922)

Understanding the Hsp90 <i>N</i>-Terminal Dynamics: Structural and Molecular Insights into the Therapeutic Activities of Anticancer Inhibitors Radicicol (RD) and Radicicol Derivative (NVP-YUA922)

Heat shock protein 90 (Hsp90) is a crucial component in carcinogenesis and serves as a molecular chaperone that facilitates protein maturation whilst protecting cells against temperature-induced stress. The function of Hsp90 is highly dependent on adenosine triphosphate (ATP) binding to the <i>...

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Bibliographic Details
Main Authors: Ayanda M. Magwenyane, Ndumiso N. Mhlongo, Monsurat M. Lawal, Daniel G. Amoako, Anou M. Somboro, Sphelele C. Sosibo, Letitia Shunmugam, Rene B. Khan, Hezekiel M. Kumalo
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:Molecules
Subjects:
Hsp90 protease
<i>N</i>-terminal
radicicol
NVP-AUY922
density functional theory (DFT)
molecular dynamics (MD)
Online Access:https://www.mdpi.com/1420-3049/25/8/1785

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