Influence of detection of pretreatment cytogenetic abnormalities on first complete remission and survival in adult acute lymphoblastic leukemia
OBJECTIVE: Treatment of acute lymphoblastic leukemia (ALL) in adults focuses on the initial assessment of the prognostic relevant cytogenetic features as well as a response-guided therapy based on molecular data. We examined the importance of molecular-cytogenetic abnormalities for complete remissio...
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| Format: | Article |
| Language: | English |
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Galenos Publishing House
2011-08-01
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| Series: | Turkish Journal of Hematology |
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| Online Access: | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=tjh&un=TJH-47135 |
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| author | Milena Georgieva Velizarova Evgueniy A. Hadjiev Kamelia V. Alexandrova Ivanka I. Dimova Draga I. Toncheva Nadya E. Dimitrova |
| author_facet | Milena Georgieva Velizarova Evgueniy A. Hadjiev Kamelia V. Alexandrova Ivanka I. Dimova Draga I. Toncheva Nadya E. Dimitrova |
| author_sort | Milena Georgieva Velizarova |
| collection | DOAJ |
| description | OBJECTIVE: Treatment of acute lymphoblastic leukemia (ALL) in adults focuses on the initial assessment of the prognostic relevant cytogenetic features as well as a response-guided therapy based on molecular data. We examined the importance of molecular-cytogenetic abnormalities for complete remission (CR) rates and the overall survival (OS) in adult ALLs. METHODS: Conventional cytogenetics and fluorescence in situ hybridization were performed on bone marrow cells from 33 newly-diagnosed ALL adults. Two karyotype categories [standard- risk group- normal karyotype, hyperdiplody and other structural aberrations, and high-risk group-t(11q23)/MLL, t(9;22)/bcr-abl, t(1;19), t(8;14), C-MYC and complex karyotype] and the biologically and clinically relevant ALL ploidy subgroups were prospectively defined. RESULTS: Chromosomal abnormalities were found in 52% of the cases with a high rate of poor-risk translocations - t(9;22), t(8q24), t(11q23), t(1;19). The total CR rate was 67% and the median time for achievement 2.33 months. Male sex, an age below 35 years and the absence of high risk translocations might have contributed to the high CR rates. Female patients, hyperdiplody, low white blood cells (WBC), and random cytogenetic aberrations had the longest OS. OS, 3- and 5-years survival periods were significantly shorter for poor-risk than standard risk group (p=.015, p=.001 and p=.005, respectively). CONCLUSION: This study emphasizes the lack of influence of cytogenetic aberrations on the CR and the time to achieve CR. However, our observations show that these aberrations are an independent prognostic factor in adult ALL - they allow predicting therapy resistance and the OS time after intense treatment. |
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| format | Article |
| id | doaj.art-dd3adcb92a6c41e1aa4d499d008742c5 |
| institution | Directory Open Access Journal |
| issn | 1308-5263 |
| language | English |
| last_indexed | 2024-04-10T11:56:20Z |
| publishDate | 2011-08-01 |
| publisher | Galenos Publishing House |
| record_format | Article |
| series | Turkish Journal of Hematology |
| spelling | doaj.art-dd3adcb92a6c41e1aa4d499d008742c52023-02-15T16:16:47ZengGalenos Publishing HouseTurkish Journal of Hematology1308-52632011-08-0128317618510.5152/tjh.2011.51TJH-47135Influence of detection of pretreatment cytogenetic abnormalities on first complete remission and survival in adult acute lymphoblastic leukemiaMilena Georgieva Velizarova0Evgueniy A. Hadjiev1Kamelia V. Alexandrova2Ivanka I. Dimova3Draga I. Toncheva4Nadya E. Dimitrova5Department Of Clinical Laboratory And Clinical Of Immunology, Alexandrovska University Hospital, Sofia, BulgariaClinic Of Hematology, Alexandrovska University Hospital, Sofia, BulgariaClinic Of Hematology, Alexandrovska University Hospital, Sofia, BulgariaDepartment Of Medical Genetics, Medical University, Sofia, BulgariaDepartment Of Medical Genetics, Medical University, Sofia, BulgariaNational Oncological Hospital, Bulgarian National Cancer Registry, Sofia, BulgariaOBJECTIVE: Treatment of acute lymphoblastic leukemia (ALL) in adults focuses on the initial assessment of the prognostic relevant cytogenetic features as well as a response-guided therapy based on molecular data. We examined the importance of molecular-cytogenetic abnormalities for complete remission (CR) rates and the overall survival (OS) in adult ALLs. METHODS: Conventional cytogenetics and fluorescence in situ hybridization were performed on bone marrow cells from 33 newly-diagnosed ALL adults. Two karyotype categories [standard- risk group- normal karyotype, hyperdiplody and other structural aberrations, and high-risk group-t(11q23)/MLL, t(9;22)/bcr-abl, t(1;19), t(8;14), C-MYC and complex karyotype] and the biologically and clinically relevant ALL ploidy subgroups were prospectively defined. RESULTS: Chromosomal abnormalities were found in 52% of the cases with a high rate of poor-risk translocations - t(9;22), t(8q24), t(11q23), t(1;19). The total CR rate was 67% and the median time for achievement 2.33 months. Male sex, an age below 35 years and the absence of high risk translocations might have contributed to the high CR rates. Female patients, hyperdiplody, low white blood cells (WBC), and random cytogenetic aberrations had the longest OS. OS, 3- and 5-years survival periods were significantly shorter for poor-risk than standard risk group (p=.015, p=.001 and p=.005, respectively). CONCLUSION: This study emphasizes the lack of influence of cytogenetic aberrations on the CR and the time to achieve CR. However, our observations show that these aberrations are an independent prognostic factor in adult ALL - they allow predicting therapy resistance and the OS time after intense treatment.https://jag.journalagent.com/z4/download_fulltext.asp?pdir=tjh&un=TJH-47135adult acute lymphoblastic leukemiacomplete remissionkaryotypeoverall survival |
| spellingShingle | Milena Georgieva Velizarova Evgueniy A. Hadjiev Kamelia V. Alexandrova Ivanka I. Dimova Draga I. Toncheva Nadya E. Dimitrova Influence of detection of pretreatment cytogenetic abnormalities on first complete remission and survival in adult acute lymphoblastic leukemia Turkish Journal of Hematology adult acute lymphoblastic leukemia complete remission karyotype overall survival |
| title | Influence of detection of pretreatment cytogenetic abnormalities on first complete remission and survival in adult acute lymphoblastic leukemia |
| title_full | Influence of detection of pretreatment cytogenetic abnormalities on first complete remission and survival in adult acute lymphoblastic leukemia |
| title_fullStr | Influence of detection of pretreatment cytogenetic abnormalities on first complete remission and survival in adult acute lymphoblastic leukemia |
| title_full_unstemmed | Influence of detection of pretreatment cytogenetic abnormalities on first complete remission and survival in adult acute lymphoblastic leukemia |
| title_short | Influence of detection of pretreatment cytogenetic abnormalities on first complete remission and survival in adult acute lymphoblastic leukemia |
| title_sort | influence of detection of pretreatment cytogenetic abnormalities on first complete remission and survival in adult acute lymphoblastic leukemia |
| topic | adult acute lymphoblastic leukemia complete remission karyotype overall survival |
| url | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=tjh&un=TJH-47135 |
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