Serotonergic system in vivo with [11C]DASB PET scans in GTP-cyclohydrolase deficient dopa-responsive dystonia patients

Serotonergic system in vivo with [11C]DASB PET scans in GTP-cyclohydrolase deficient dopa-responsive dystonia patients

Abstract GTP-cyclohydrolase deficiency in dopa-responsive dystonia (DRD) patients impairs the biosynthesis of dopamine, but also of serotonin. The high prevalence of non-motor symptoms suggests involvement of the serotonergic pathway. Our study aimed to investigate the serotonergic system in vivo in...

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Bibliographic Details
Main Authors: Elze R. Timmers, Débora E. Peretti, Marenka Smit, Bauke M. de Jong, Rudi A. J. O. Dierckx, Anouk Kuiper, Tom J. de Koning, David Vállez García, Marina A. J. Tijssen
Format: Article
Language:English
Published: Nature Portfolio 2022-04-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-10067-5

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https://doi.org/10.1038/s41598-022-10067-5

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