Novel banana lectin CAR-T cells to target pancreatic tumors and tumor-associated stroma

Novel banana lectin CAR-T cells to target pancreatic tumors and tumor-associated stroma

Background Cell therapies for solid tumors are thwarted by the hostile tumor microenvironment (TME) and by heterogeneous expression of tumor target antigens. We address both limitations with a novel class of chimeric antigen receptors based on plant lectins, which recognize the aberrant sugar residu...

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Bibliographic Details
Main Authors:	Malcolm K Brenner, Challice Bonifant, Norihiro Watanabe, Mary K McKenna, Daniel Brenner, Ada Ozcan, Maureen Legendre, Dafydd G Thomas, Christopher Ashwood, Richard D Cummings, David M Markovitz
Format:	Article
Language:	English
Published:	BMJ Publishing Group 2023-01-01
Series:	Journal for ImmunoTherapy of Cancer
Online Access:	https://jitc.bmj.com/content/11/1/e005891.full

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