Atractylodin Attenuates Dextran Sulfate Sodium-Induced Colitis by Alleviating Gut Microbiota Dysbiosis and Inhibiting Inflammatory Response Through the MAPK Pathway

Atractylodin Attenuates Dextran Sulfate Sodium-Induced Colitis by Alleviating Gut Microbiota Dysbiosis and Inhibiting Inflammatory Response Through the MAPK Pathway

In this study, we investigated the therapeutic effects and mechanism of atractylodin (ATL) on dextran sulfate sodium (DSS)-induced ulcerative colitis in mice. We found that atractylodin could significantly reverse the effects of DSS-induced ulcerative colitis, such as weight loss, disease activity i...

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Bibliographic Details
Main Authors: Linghang Qu, Xiong Lin, Chunlian Liu, Chang Ke, Zhongshi Zhou, Kang Xu, Guosheng Cao, Yanju Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Pharmacology
Subjects:
ulcerative colitis
malonylation
atractylodin
MAPK pathway
tight junctions
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.665376/full

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