Hydroxychloroquine- A new treatment option for erosive oral lichen planus
Context: Oral Lichen planus (OLP) is a chronic, debilitating, immune-mediated disease whose management is considered a challenge in medical science. Aims: To quantitatively evaluate the effect of administration of enteral hydroxychloroquine (HCQS) as a monotherapy for six months on the extent and se...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2021-01-01
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| Series: | Indian Journal of Dental Research |
| Subjects: | |
| Online Access: | http://www.ijdr.in/article.asp?issn=0970-9290;year=2021;volume=32;issue=2;spage=192;epage=198;aulast=Raj |
| _version_ | 1817985723530215424 |
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| author | Subash Chandra Raj Debajani Baral Lokanath Garhnayak Annuroopa Mahapatra Kaushik Patnaik Shaheda Tabassum Jayant Kumar Dash |
| author_facet | Subash Chandra Raj Debajani Baral Lokanath Garhnayak Annuroopa Mahapatra Kaushik Patnaik Shaheda Tabassum Jayant Kumar Dash |
| author_sort | Subash Chandra Raj |
| collection | DOAJ |
| description | Context: Oral Lichen planus (OLP) is a chronic, debilitating, immune-mediated disease whose management is considered a challenge in medical science. Aims: To quantitatively evaluate the effect of administration of enteral hydroxychloroquine (HCQS) as a monotherapy for six months on the extent and severity of erosive OLP using reticular score, erythema score and ulcerative score (REU score), and to subjectively evaluate the success of HCQS as a therapeutic drug for OLP-e using Tel Aviv-San Francisco Scale, visual analogue scale (VAS) and severity of burning sensation (BURN score). Settings and Design: Prospective clinical trial. Methods and Material: A total of 45 subjects received 200 mg of HCQS bid for six months. REU, VAS, BURN scores and Tel Aviv-San Francisco Scale readings were taken at the beginning of the study (baseline) and three- and six-month intervals post administration of enteral HCQS. Subjects were examined for any adverse drug outcomes for one year after the cessation of enteric HCQS therapy. Data were analysed with SPSS version 25. Results: There was a stark reduction in REU, VAS and BURN scores during the study period, with a statistically significant reduction (P < 0.05) seen at three- and six-month time intervals as compared to baseline. Further, the mean of change in R, E and U scores showed a statistically significant difference, with the highest reduction seen at baseline to six-month time interval. The Tel Aviv-San Francisco Scale showed 70%–100% remission in disease in more than 70% of subjects. Conclusions: Enteral HCQS can be considered a viable treatment option for the enigma that is erosive OLP. |
| first_indexed | 2024-04-14T00:00:41Z |
| format | Article |
| id | doaj.art-dd3e4eaf64b043a7b4f773f6e4a8c735 |
| institution | Directory Open Access Journal |
| issn | 0970-9290 1998-3603 |
| language | English |
| last_indexed | 2024-04-14T00:00:41Z |
| publishDate | 2021-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Dental Research |
| spelling | doaj.art-dd3e4eaf64b043a7b4f773f6e4a8c7352022-12-22T02:23:42ZengWolters Kluwer Medknow PublicationsIndian Journal of Dental Research0970-92901998-36032021-01-0132219219810.4103/ijdr.IJDR_943_20Hydroxychloroquine- A new treatment option for erosive oral lichen planusSubash Chandra RajDebajani BaralLokanath GarhnayakAnnuroopa MahapatraKaushik PatnaikShaheda TabassumJayant Kumar DashContext: Oral Lichen planus (OLP) is a chronic, debilitating, immune-mediated disease whose management is considered a challenge in medical science. Aims: To quantitatively evaluate the effect of administration of enteral hydroxychloroquine (HCQS) as a monotherapy for six months on the extent and severity of erosive OLP using reticular score, erythema score and ulcerative score (REU score), and to subjectively evaluate the success of HCQS as a therapeutic drug for OLP-e using Tel Aviv-San Francisco Scale, visual analogue scale (VAS) and severity of burning sensation (BURN score). Settings and Design: Prospective clinical trial. Methods and Material: A total of 45 subjects received 200 mg of HCQS bid for six months. REU, VAS, BURN scores and Tel Aviv-San Francisco Scale readings were taken at the beginning of the study (baseline) and three- and six-month intervals post administration of enteral HCQS. Subjects were examined for any adverse drug outcomes for one year after the cessation of enteric HCQS therapy. Data were analysed with SPSS version 25. Results: There was a stark reduction in REU, VAS and BURN scores during the study period, with a statistically significant reduction (P < 0.05) seen at three- and six-month time intervals as compared to baseline. Further, the mean of change in R, E and U scores showed a statistically significant difference, with the highest reduction seen at baseline to six-month time interval. The Tel Aviv-San Francisco Scale showed 70%–100% remission in disease in more than 70% of subjects. Conclusions: Enteral HCQS can be considered a viable treatment option for the enigma that is erosive OLP.http://www.ijdr.in/article.asp?issn=0970-9290;year=2021;volume=32;issue=2;spage=192;epage=198;aulast=Rajerosive oral lichen planushydroxychloroquinereu score |
| spellingShingle | Subash Chandra Raj Debajani Baral Lokanath Garhnayak Annuroopa Mahapatra Kaushik Patnaik Shaheda Tabassum Jayant Kumar Dash Hydroxychloroquine- A new treatment option for erosive oral lichen planus Indian Journal of Dental Research erosive oral lichen planus hydroxychloroquine reu score |
| title | Hydroxychloroquine- A new treatment option for erosive oral lichen planus |
| title_full | Hydroxychloroquine- A new treatment option for erosive oral lichen planus |
| title_fullStr | Hydroxychloroquine- A new treatment option for erosive oral lichen planus |
| title_full_unstemmed | Hydroxychloroquine- A new treatment option for erosive oral lichen planus |
| title_short | Hydroxychloroquine- A new treatment option for erosive oral lichen planus |
| title_sort | hydroxychloroquine a new treatment option for erosive oral lichen planus |
| topic | erosive oral lichen planus hydroxychloroquine reu score |
| url | http://www.ijdr.in/article.asp?issn=0970-9290;year=2021;volume=32;issue=2;spage=192;epage=198;aulast=Raj |
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