Clinical application of nitric oxide in ischemia and reperfusion injury: A literature review
Ischemia–reperfusion injury (IRI) is a series of multifactorial cellular events that lead to increased cellular dysfunction after the restoration of oxygen delivery to hypoxic tissue, which can result in acute heart failure and cerebral dysfunction. This injury is severe and would lead to significan...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2020-01-01
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| Series: | Brain Circulation |
| Subjects: | |
| Online Access: | http://www.braincirculation.org/article.asp?issn=2394-8108;year=2020;volume=6;issue=4;spage=248;epage=253;aulast=Jiang |
| _version_ | 1818412753631576064 |
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| author | Shangqian Jiang Chaitu Dandu Xiaokun Geng |
| author_facet | Shangqian Jiang Chaitu Dandu Xiaokun Geng |
| author_sort | Shangqian Jiang |
| collection | DOAJ |
| description | Ischemia–reperfusion injury (IRI) is a series of multifactorial cellular events that lead to increased cellular dysfunction after the restoration of oxygen delivery to hypoxic tissue, which can result in acute heart failure and cerebral dysfunction. This injury is severe and would lead to significant morbidity and mortality and poses an important therapeutic challenge for physicians. Nitric oxide (NO) minimizes the deleterious effects of IRI on cells. NO donors, such as organic nitrates and sodium nitroprusside, are used systematically to treat heart failure, angina, and pulmonary hypertension. Inhaled NO gas was approved by the FDA in 1999 to treat hypoxic newborns, and its beneficial ameliorations reach outside the realm of lung disease. This review will summarize the clinical application of NO in IRI. |
| first_indexed | 2024-12-14T10:52:19Z |
| format | Article |
| id | doaj.art-dd3e5f40a29c475290e63c475b09159f |
| institution | Directory Open Access Journal |
| issn | 2455-4626 |
| language | English |
| last_indexed | 2024-12-14T10:52:19Z |
| publishDate | 2020-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Brain Circulation |
| spelling | doaj.art-dd3e5f40a29c475290e63c475b09159f2022-12-21T23:05:09ZengWolters Kluwer Medknow PublicationsBrain Circulation2455-46262020-01-016424825310.4103/bc.bc_69_20Clinical application of nitric oxide in ischemia and reperfusion injury: A literature reviewShangqian JiangChaitu DanduXiaokun GengIschemia–reperfusion injury (IRI) is a series of multifactorial cellular events that lead to increased cellular dysfunction after the restoration of oxygen delivery to hypoxic tissue, which can result in acute heart failure and cerebral dysfunction. This injury is severe and would lead to significant morbidity and mortality and poses an important therapeutic challenge for physicians. Nitric oxide (NO) minimizes the deleterious effects of IRI on cells. NO donors, such as organic nitrates and sodium nitroprusside, are used systematically to treat heart failure, angina, and pulmonary hypertension. Inhaled NO gas was approved by the FDA in 1999 to treat hypoxic newborns, and its beneficial ameliorations reach outside the realm of lung disease. This review will summarize the clinical application of NO in IRI.http://www.braincirculation.org/article.asp?issn=2394-8108;year=2020;volume=6;issue=4;spage=248;epage=253;aulast=Jianginhaled nitric oxideischemic strokemyocardial infarctionnitric oxide donor |
| spellingShingle | Shangqian Jiang Chaitu Dandu Xiaokun Geng Clinical application of nitric oxide in ischemia and reperfusion injury: A literature review Brain Circulation inhaled nitric oxide ischemic stroke myocardial infarction nitric oxide donor |
| title | Clinical application of nitric oxide in ischemia and reperfusion injury: A literature review |
| title_full | Clinical application of nitric oxide in ischemia and reperfusion injury: A literature review |
| title_fullStr | Clinical application of nitric oxide in ischemia and reperfusion injury: A literature review |
| title_full_unstemmed | Clinical application of nitric oxide in ischemia and reperfusion injury: A literature review |
| title_short | Clinical application of nitric oxide in ischemia and reperfusion injury: A literature review |
| title_sort | clinical application of nitric oxide in ischemia and reperfusion injury a literature review |
| topic | inhaled nitric oxide ischemic stroke myocardial infarction nitric oxide donor |
| url | http://www.braincirculation.org/article.asp?issn=2394-8108;year=2020;volume=6;issue=4;spage=248;epage=253;aulast=Jiang |
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