Modelling host-Trypanosoma brucei gambiense interactions in vitro using human induced pluripotent stem cell-derived cortical brain organoids [version 2; peer review: 2 approved]

Modelling host-Trypanosoma brucei gambiense interactions in vitro using human induced pluripotent stem cell-derived cortical brain organoids [version 2; peer review: 2 approved]

Background: Sleeping sickness is caused by the extracellular parasite Trypanosoma brucei and is associated with neuroinflammation and neuropsychiatric disorders, including disruption of sleep/wake patterns, and is now recognised as a circadian disorder. Sleeping sickness is traditionally studied usi...

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Bibliographic Details
Main Authors: Juan F. Quintana, Matthew C. Sinton, Jay Gopalakrishnan, Praveena Chandrasegaran, Agatha Nabilla Lestari
Format: Article
Language:English
Published: F1000 Research Ltd 2023-07-01
Series:F1000Research
Subjects:
Brain organoids
sleeping sickness African trypanosomes
brain infection
in vitro culture
eng
Online Access:https://f1000research.com/articles/12-437/v2

Internet

https://f1000research.com/articles/12-437/v2

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