Mendelian Randomization Analysis Reveals Statins Potentially Increase Amyotrophic Lateral Sclerosis Risk Independent of Peripheral Cholesterol-Lowering Effects

Mendelian Randomization Analysis Reveals Statins Potentially Increase Amyotrophic Lateral Sclerosis Risk Independent of Peripheral Cholesterol-Lowering Effects

Background: Observational studies suggest that statins may affect amyotrophic lateral sclerosis (ALS). However, they are limited by confounding and reverse causality biases. Therefore, we aimed to investigate the potential causal associations between statins and ALS using a mendelian randomization (...

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Bibliographic Details
Main Authors: Wenjing Wang, Linjing Zhang, Kailin Xia, Tao Huang, Dongsheng Fan
Format: Article
Language:English
Published: MDPI AG 2023-05-01
Series:Biomedicines
Subjects:
amyotrophic lateral sclerosis
statins
mendelian randomization
causality
Hydroxymethylglutaryl-CoA reductase inhibitors
lipids
Online Access:https://www.mdpi.com/2227-9059/11/5/1359

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