Corpus Callosotomy in 3 Cavalier King Charles Spaniel Dogs with Drug-Resistant Epilepsy
Corpus callosotomy (CC) is an established palliative surgery for human patients with drug-resistant epilepsy (DRE), especially those with generalized seizures and multiple or unknown epileptogenic focus. However, there are no reports to describe CC in canine patients with epilepsy. Three client-owne...
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| Format: | Article |
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MDPI AG
2021-11-01
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| Series: | Brain Sciences |
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| Online Access: | https://www.mdpi.com/2076-3425/11/11/1462 |
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| author | Rikako Asada Satoshi Mizuno Yoshihiko Yu Yuji Hamamoto Tetsuya Anazawa Daisuke Ito Masato Kitagawa Daisuke Hasegawa |
| author_facet | Rikako Asada Satoshi Mizuno Yoshihiko Yu Yuji Hamamoto Tetsuya Anazawa Daisuke Ito Masato Kitagawa Daisuke Hasegawa |
| author_sort | Rikako Asada |
| collection | DOAJ |
| description | Corpus callosotomy (CC) is an established palliative surgery for human patients with drug-resistant epilepsy (DRE), especially those with generalized seizures and multiple or unknown epileptogenic focus. However, there are no reports to describe CC in canine patients with epilepsy. Three client-owned Cavalier King Charles Spaniels with DRE are included in this case series. In presurgical evaluations, an apparent epileptogenic zone was not detected in each dog and CC was conducted. Total CC was performed in one dog, whereas the other two received partial CC. One dog recovered from surgery without any complications, but died suddenly by an unknown cause at 10 h after surgery. For the other two dogs, postoperative evaluations including seizure outcomes, complications, and quality of life of the dogs and owners were assessed for at least 12 months. Both dogs showed a remarkable decrease in seizure frequency (averaged 80.3% reduction) and severity after surgery. The antiseizure medications were maintained, and not only the mentation and activity of the dogs, but also the quality of life of dogs and owners were improved postoperatively. Although technical improvement and more large-scale studies are needed, CC is a treatment option for dogs with DRE in veterinary medicine. |
| first_indexed | 2024-03-10T05:39:45Z |
| format | Article |
| id | doaj.art-dd411e34ec1a43a88e15a64cbe6fdadf |
| institution | Directory Open Access Journal |
| issn | 2076-3425 |
| language | English |
| last_indexed | 2024-03-10T05:39:45Z |
| publishDate | 2021-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Brain Sciences |
| spelling | doaj.art-dd411e34ec1a43a88e15a64cbe6fdadf2023-11-22T22:38:02ZengMDPI AGBrain Sciences2076-34252021-11-011111146210.3390/brainsci11111462Corpus Callosotomy in 3 Cavalier King Charles Spaniel Dogs with Drug-Resistant EpilepsyRikako Asada0Satoshi Mizuno1Yoshihiko Yu2Yuji Hamamoto3Tetsuya Anazawa4Daisuke Ito5Masato Kitagawa6Daisuke Hasegawa7Laboratory of Veterinary Radiology, Nippon Veterinary and Life Science University, Musashino 180-8602, JapanLaboratory of Veterinary Radiology, Nippon Veterinary and Life Science University, Musashino 180-8602, JapanLaboratory of Veterinary Radiology, Nippon Veterinary and Life Science University, Musashino 180-8602, JapanVeterinary Medical Teaching Hospital, Nippon Veterinary and Life Science University, Musashino 180-8602, JapanNeurology and Neurosurgery Service, Japan Animal Referral Medical Center Nagoya, Nagoya 468-0003, JapanLaboratory of Veterinary Neurology, Department of Veterinary Medicine, College of Bioresource Sciences, Nihon University, Fujisawa 252-0880, JapanLaboratory of Veterinary Neurology, Department of Veterinary Medicine, College of Bioresource Sciences, Nihon University, Fujisawa 252-0880, JapanLaboratory of Veterinary Radiology, Nippon Veterinary and Life Science University, Musashino 180-8602, JapanCorpus callosotomy (CC) is an established palliative surgery for human patients with drug-resistant epilepsy (DRE), especially those with generalized seizures and multiple or unknown epileptogenic focus. However, there are no reports to describe CC in canine patients with epilepsy. Three client-owned Cavalier King Charles Spaniels with DRE are included in this case series. In presurgical evaluations, an apparent epileptogenic zone was not detected in each dog and CC was conducted. Total CC was performed in one dog, whereas the other two received partial CC. One dog recovered from surgery without any complications, but died suddenly by an unknown cause at 10 h after surgery. For the other two dogs, postoperative evaluations including seizure outcomes, complications, and quality of life of the dogs and owners were assessed for at least 12 months. Both dogs showed a remarkable decrease in seizure frequency (averaged 80.3% reduction) and severity after surgery. The antiseizure medications were maintained, and not only the mentation and activity of the dogs, but also the quality of life of dogs and owners were improved postoperatively. Although technical improvement and more large-scale studies are needed, CC is a treatment option for dogs with DRE in veterinary medicine.https://www.mdpi.com/2076-3425/11/11/1462corpus callosotomydogdrug-resistant epilepsyepilepsy surgeryveterinary |
| spellingShingle | Rikako Asada Satoshi Mizuno Yoshihiko Yu Yuji Hamamoto Tetsuya Anazawa Daisuke Ito Masato Kitagawa Daisuke Hasegawa Corpus Callosotomy in 3 Cavalier King Charles Spaniel Dogs with Drug-Resistant Epilepsy Brain Sciences corpus callosotomy dog drug-resistant epilepsy epilepsy surgery veterinary |
| title | Corpus Callosotomy in 3 Cavalier King Charles Spaniel Dogs with Drug-Resistant Epilepsy |
| title_full | Corpus Callosotomy in 3 Cavalier King Charles Spaniel Dogs with Drug-Resistant Epilepsy |
| title_fullStr | Corpus Callosotomy in 3 Cavalier King Charles Spaniel Dogs with Drug-Resistant Epilepsy |
| title_full_unstemmed | Corpus Callosotomy in 3 Cavalier King Charles Spaniel Dogs with Drug-Resistant Epilepsy |
| title_short | Corpus Callosotomy in 3 Cavalier King Charles Spaniel Dogs with Drug-Resistant Epilepsy |
| title_sort | corpus callosotomy in 3 cavalier king charles spaniel dogs with drug resistant epilepsy |
| topic | corpus callosotomy dog drug-resistant epilepsy epilepsy surgery veterinary |
| url | https://www.mdpi.com/2076-3425/11/11/1462 |
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