Extensive and diverse patterns of cell death sculpt neural networks in insects
Changes to the structure and function of neural networks are thought to underlie the evolutionary adaptation of animal behaviours. Among the many developmental phenomena that generate change programmed cell death (PCD) appears to play a key role. We show that cell death occurs continuously throughou...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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eLife Sciences Publications Ltd
2020-09-01
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| Series: | eLife |
| Subjects: | |
| Online Access: | https://elifesciences.org/articles/59566 |
| _version_ | 1811199640182194176 |
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| author | Sinziana Pop Chin-Lin Chen Connor J Sproston Shu Kondo Pavan Ramdya Darren W Williams |
| author_facet | Sinziana Pop Chin-Lin Chen Connor J Sproston Shu Kondo Pavan Ramdya Darren W Williams |
| author_sort | Sinziana Pop |
| collection | DOAJ |
| description | Changes to the structure and function of neural networks are thought to underlie the evolutionary adaptation of animal behaviours. Among the many developmental phenomena that generate change programmed cell death (PCD) appears to play a key role. We show that cell death occurs continuously throughout insect neurogenesis and happens soon after neurons are born. Mimicking an evolutionary role for increasing cell numbers, we artificially block PCD in the medial neuroblast lineage in Drosophila melanogaster, which results in the production of ‘undead’ neurons with complex arborisations and distinct neurotransmitter identities. Activation of these ‘undead’ neurons and recordings of neural activity in behaving animals demonstrate that they are functional. Focusing on two dipterans which have lost flight during evolution we reveal that reductions in populations of flight interneurons are likely caused by increased cell death during development. Our findings suggest that the evolutionary modulation of death-based patterning could generate novel network configurations. |
| first_indexed | 2024-04-12T01:50:57Z |
| format | Article |
| id | doaj.art-dd411e8e76224131895babedf8d34be9 |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-12T01:50:57Z |
| publishDate | 2020-09-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-dd411e8e76224131895babedf8d34be92022-12-22T03:52:56ZengeLife Sciences Publications LtdeLife2050-084X2020-09-01910.7554/eLife.59566Extensive and diverse patterns of cell death sculpt neural networks in insectsSinziana Pop0https://orcid.org/0000-0002-8811-8307Chin-Lin Chen1https://orcid.org/0000-0002-4968-4920Connor J Sproston2https://orcid.org/0000-0003-2491-0589Shu Kondo3https://orcid.org/0000-0002-4625-8379Pavan Ramdya4https://orcid.org/0000-0001-5425-4610Darren W Williams5https://orcid.org/0000-0001-5917-4935Centre for Developmental Neurobiology, King's College London, London, United KingdomNeuroengineering Laboratory, Brain Mind Institute and Institute of Bioengineering, École Polytechnique Fédérale de Lausanne, Lausanne, SwitzerlandCentre for Developmental Neurobiology, King's College London, London, United KingdomGenetic Strains Research Center, National Institute of Genetics, Shizuoka, JapanNeuroengineering Laboratory, Brain Mind Institute and Institute of Bioengineering, École Polytechnique Fédérale de Lausanne, Lausanne, SwitzerlandCentre for Developmental Neurobiology, King's College London, London, United KingdomChanges to the structure and function of neural networks are thought to underlie the evolutionary adaptation of animal behaviours. Among the many developmental phenomena that generate change programmed cell death (PCD) appears to play a key role. We show that cell death occurs continuously throughout insect neurogenesis and happens soon after neurons are born. Mimicking an evolutionary role for increasing cell numbers, we artificially block PCD in the medial neuroblast lineage in Drosophila melanogaster, which results in the production of ‘undead’ neurons with complex arborisations and distinct neurotransmitter identities. Activation of these ‘undead’ neurons and recordings of neural activity in behaving animals demonstrate that they are functional. Focusing on two dipterans which have lost flight during evolution we reveal that reductions in populations of flight interneurons are likely caused by increased cell death during development. Our findings suggest that the evolutionary modulation of death-based patterning could generate novel network configurations.https://elifesciences.org/articles/59566Braula coecaCrataerina pallidaThermobia domestica |
| spellingShingle | Sinziana Pop Chin-Lin Chen Connor J Sproston Shu Kondo Pavan Ramdya Darren W Williams Extensive and diverse patterns of cell death sculpt neural networks in insects eLife Braula coeca Crataerina pallida Thermobia domestica |
| title | Extensive and diverse patterns of cell death sculpt neural networks in insects |
| title_full | Extensive and diverse patterns of cell death sculpt neural networks in insects |
| title_fullStr | Extensive and diverse patterns of cell death sculpt neural networks in insects |
| title_full_unstemmed | Extensive and diverse patterns of cell death sculpt neural networks in insects |
| title_short | Extensive and diverse patterns of cell death sculpt neural networks in insects |
| title_sort | extensive and diverse patterns of cell death sculpt neural networks in insects |
| topic | Braula coeca Crataerina pallida Thermobia domestica |
| url | https://elifesciences.org/articles/59566 |
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