Renal primary cilia lengthen in the progression of diabetic kidney disease
Diabetic kidney disease (DKD) is the leading cause of end-stage renal disease, and its early pathogenesis is critical. Shear stress caused by glomerular hyperfiltration contributes to the initiation of kidney injury in diabetes. The primary cilium of renal tubular epithelial cells (RTECs) is an impo...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-11-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2022.984452/full |
| _version_ | 1811312328459681792 |
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| author | Yunfeng Bai Ping Li Jiaona Liu Lu Zhang Shaoyuan Cui Cuiting Wei Cuiting Wei Bo Fu Xuefeng Sun Guangyan Cai Quan Hong Xiangmei Chen |
| author_facet | Yunfeng Bai Ping Li Jiaona Liu Lu Zhang Shaoyuan Cui Cuiting Wei Cuiting Wei Bo Fu Xuefeng Sun Guangyan Cai Quan Hong Xiangmei Chen |
| author_sort | Yunfeng Bai |
| collection | DOAJ |
| description | Diabetic kidney disease (DKD) is the leading cause of end-stage renal disease, and its early pathogenesis is critical. Shear stress caused by glomerular hyperfiltration contributes to the initiation of kidney injury in diabetes. The primary cilium of renal tubular epithelial cells (RTECs) is an important mechanical force sensor of shear stress and regulates energy metabolism homeostasis in RTECs to ensure energy supply for reabsorption functions, but little is known about the alterations in the renal cilium number and length during the progression of DKD. Here, we demonstrate that aberrant ciliogenesis and dramatic increase in the cilium length, the number of ciliated cells, and the length of cilia are positively correlated with the DKD class in the kidney biopsies of DKD patients by super-resolution imaging and appropriate statical analysis methods. This finding was further confirmed in STZ-induced or db/db diabetic mice. These results suggest that the number and length of renal cilia may be clinically relevant indicators and that cilia will be attractive therapeutic targets for DKD. |
| first_indexed | 2024-04-13T10:34:18Z |
| format | Article |
| id | doaj.art-dd41c22f57e642b1bffb1b2cda5c5417 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-04-13T10:34:18Z |
| publishDate | 2022-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-dd41c22f57e642b1bffb1b2cda5c54172022-12-22T02:50:06ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922022-11-011310.3389/fendo.2022.984452984452Renal primary cilia lengthen in the progression of diabetic kidney diseaseYunfeng Bai0Ping Li1Jiaona Liu2Lu Zhang3Shaoyuan Cui4Cuiting Wei5Cuiting Wei6Bo Fu7Xuefeng Sun8Guangyan Cai9Quan Hong10Xiangmei Chen11Department of Nephrology, First Medical Center of Chinese People's Liberation Army (PLA) General Hospital, Nephrology Institute of the Chinese People’s Liberation Army, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing Key Laboratory of Kidney Disease Research, Beijing, ChinaDepartment of Nephrology, First Medical Center of Chinese People's Liberation Army (PLA) General Hospital, Nephrology Institute of the Chinese People’s Liberation Army, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing Key Laboratory of Kidney Disease Research, Beijing, ChinaDepartment of Nephrology, First Medical Center of Chinese People's Liberation Army (PLA) General Hospital, Nephrology Institute of the Chinese People’s Liberation Army, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing Key Laboratory of Kidney Disease Research, Beijing, ChinaDepartment of Nephrology, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, ChinaDepartment of Nephrology, First Medical Center of Chinese People's Liberation Army (PLA) General Hospital, Nephrology Institute of the Chinese People’s Liberation Army, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing Key Laboratory of Kidney Disease Research, Beijing, ChinaDepartment of Nephrology, First Medical Center of Chinese People's Liberation Army (PLA) General Hospital, Nephrology Institute of the Chinese People’s Liberation Army, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing Key Laboratory of Kidney Disease Research, Beijing, ChinaInstitute of Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou, ChinaDepartment of Nephrology, First Medical Center of Chinese People's Liberation Army (PLA) General Hospital, Nephrology Institute of the Chinese People’s Liberation Army, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing Key Laboratory of Kidney Disease Research, Beijing, ChinaDepartment of Nephrology, First Medical Center of Chinese People's Liberation Army (PLA) General Hospital, Nephrology Institute of the Chinese People’s Liberation Army, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing Key Laboratory of Kidney Disease Research, Beijing, ChinaDepartment of Nephrology, First Medical Center of Chinese People's Liberation Army (PLA) General Hospital, Nephrology Institute of the Chinese People’s Liberation Army, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing Key Laboratory of Kidney Disease Research, Beijing, ChinaDepartment of Nephrology, First Medical Center of Chinese People's Liberation Army (PLA) General Hospital, Nephrology Institute of the Chinese People’s Liberation Army, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing Key Laboratory of Kidney Disease Research, Beijing, ChinaDepartment of Nephrology, First Medical Center of Chinese People's Liberation Army (PLA) General Hospital, Nephrology Institute of the Chinese People’s Liberation Army, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing Key Laboratory of Kidney Disease Research, Beijing, ChinaDiabetic kidney disease (DKD) is the leading cause of end-stage renal disease, and its early pathogenesis is critical. Shear stress caused by glomerular hyperfiltration contributes to the initiation of kidney injury in diabetes. The primary cilium of renal tubular epithelial cells (RTECs) is an important mechanical force sensor of shear stress and regulates energy metabolism homeostasis in RTECs to ensure energy supply for reabsorption functions, but little is known about the alterations in the renal cilium number and length during the progression of DKD. Here, we demonstrate that aberrant ciliogenesis and dramatic increase in the cilium length, the number of ciliated cells, and the length of cilia are positively correlated with the DKD class in the kidney biopsies of DKD patients by super-resolution imaging and appropriate statical analysis methods. This finding was further confirmed in STZ-induced or db/db diabetic mice. These results suggest that the number and length of renal cilia may be clinically relevant indicators and that cilia will be attractive therapeutic targets for DKD.https://www.frontiersin.org/articles/10.3389/fendo.2022.984452/fulldiabetic kidney diseaseprimary ciliarenal tubular epithelial cellciliotherapytherapeutic target |
| spellingShingle | Yunfeng Bai Ping Li Jiaona Liu Lu Zhang Shaoyuan Cui Cuiting Wei Cuiting Wei Bo Fu Xuefeng Sun Guangyan Cai Quan Hong Xiangmei Chen Renal primary cilia lengthen in the progression of diabetic kidney disease Frontiers in Endocrinology diabetic kidney disease primary cilia renal tubular epithelial cell ciliotherapy therapeutic target |
| title | Renal primary cilia lengthen in the progression of diabetic kidney disease |
| title_full | Renal primary cilia lengthen in the progression of diabetic kidney disease |
| title_fullStr | Renal primary cilia lengthen in the progression of diabetic kidney disease |
| title_full_unstemmed | Renal primary cilia lengthen in the progression of diabetic kidney disease |
| title_short | Renal primary cilia lengthen in the progression of diabetic kidney disease |
| title_sort | renal primary cilia lengthen in the progression of diabetic kidney disease |
| topic | diabetic kidney disease primary cilia renal tubular epithelial cell ciliotherapy therapeutic target |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2022.984452/full |
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