Pharmacokinetic interaction of tulathromycin with Flunixin meglumine after intravenous injection in goats
The pharmacokinetic aspects of tulathromycin (2.5 mg/kg b.w.) were studied following intravenous administration alone and in combination with flunixin meglumine (2.2 mg/kg b.w) in apparently healthy goats. Tulathromycin concentrations in serum were determined by microbiological assay technique using...
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| Format: | Article |
| Language: | English |
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Faculty of Veterinary Medicine, Beni-Suef University
2016-12-01
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| Series: | Journal of Veterinary Medical Research |
| Subjects: | |
| Online Access: | http://www.bsu.edu.eg/bsujournals/Content.aspx?paperId=464&cat_id=1 |
| _version_ | 1819105866654154752 |
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| author | M. Adam M. A. Tohamy S.E. El-Sadek Abeer M. Radi |
| author_facet | M. Adam M. A. Tohamy S.E. El-Sadek Abeer M. Radi |
| author_sort | M. Adam |
| collection | DOAJ |
| description | The pharmacokinetic aspects of tulathromycin (2.5 mg/kg b.w.) were studied following intravenous administration alone and in combination with flunixin meglumine (2.2 mg/kg b.w) in apparently healthy goats. Tulathromycin concentrations in serum were determined by microbiological assay technique using Bacillus subtiles (ATCC 66343) as test organism. The half-lives of distribution and elimination (t0.5(a)and to.5(p)) were 0.071, 0.046 and 6.43, and 5.05 h. following intravenous injection of tulathromycin alone and in combination with flunixin, respectively. Volume of distribution at steady state (Vdss) was 0.249 and 0.96l/kg., mean residence time (MRT) was 6.27 and 5.99 h and total body clearance (ClB) was 0.046 and 0.17 l/kg/hr., respectively. It was concluded that flunixin significantly altered the pharmacokinetics of tulathromycin by increase its distribution and accelerate its elimination from body. Therefore care should be taken during use of tulathromycin in goats concurrently with flunixin. |
| first_indexed | 2024-12-22T02:29:03Z |
| format | Article |
| id | doaj.art-dd44df6f41034fc4a771e8b08924f916 |
| institution | Directory Open Access Journal |
| issn | 2357-0512 2357-0520 |
| language | English |
| last_indexed | 2024-12-22T02:29:03Z |
| publishDate | 2016-12-01 |
| publisher | Faculty of Veterinary Medicine, Beni-Suef University |
| record_format | Article |
| series | Journal of Veterinary Medical Research |
| spelling | doaj.art-dd44df6f41034fc4a771e8b08924f9162022-12-21T18:41:56ZengFaculty of Veterinary Medicine, Beni-Suef UniversityJournal of Veterinary Medical Research2357-05122357-05202016-12-01232199207Pharmacokinetic interaction of tulathromycin with Flunixin meglumine after intravenous injection in goatsM. Adam0 M. A. Tohamy1S.E. El-Sadek2Abeer M. Radi3Pharmacology Department, Faculty of Veterinary Medicine, Beni-Suef University, EgyptPharmacology Department, Faculty of Veterinary Medicine, Beni-Suef University, EgyptPharmacology Department, Faculty of Veterinary Medicine, Beni-Suef University, EgyptPharmacology Department, Faculty of Veterinary Medicine, Beni-Suef University, EgyptThe pharmacokinetic aspects of tulathromycin (2.5 mg/kg b.w.) were studied following intravenous administration alone and in combination with flunixin meglumine (2.2 mg/kg b.w) in apparently healthy goats. Tulathromycin concentrations in serum were determined by microbiological assay technique using Bacillus subtiles (ATCC 66343) as test organism. The half-lives of distribution and elimination (t0.5(a)and to.5(p)) were 0.071, 0.046 and 6.43, and 5.05 h. following intravenous injection of tulathromycin alone and in combination with flunixin, respectively. Volume of distribution at steady state (Vdss) was 0.249 and 0.96l/kg., mean residence time (MRT) was 6.27 and 5.99 h and total body clearance (ClB) was 0.046 and 0.17 l/kg/hr., respectively. It was concluded that flunixin significantly altered the pharmacokinetics of tulathromycin by increase its distribution and accelerate its elimination from body. Therefore care should be taken during use of tulathromycin in goats concurrently with flunixin.http://www.bsu.edu.eg/bsujournals/Content.aspx?paperId=464&cat_id=1PharmacokineticsTulathromycinFlunixinIntravenous |
| spellingShingle | M. Adam M. A. Tohamy S.E. El-Sadek Abeer M. Radi Pharmacokinetic interaction of tulathromycin with Flunixin meglumine after intravenous injection in goats Journal of Veterinary Medical Research Pharmacokinetics Tulathromycin Flunixin Intravenous |
| title | Pharmacokinetic interaction of tulathromycin with Flunixin meglumine after intravenous injection in goats |
| title_full | Pharmacokinetic interaction of tulathromycin with Flunixin meglumine after intravenous injection in goats |
| title_fullStr | Pharmacokinetic interaction of tulathromycin with Flunixin meglumine after intravenous injection in goats |
| title_full_unstemmed | Pharmacokinetic interaction of tulathromycin with Flunixin meglumine after intravenous injection in goats |
| title_short | Pharmacokinetic interaction of tulathromycin with Flunixin meglumine after intravenous injection in goats |
| title_sort | pharmacokinetic interaction of tulathromycin with flunixin meglumine after intravenous injection in goats |
| topic | Pharmacokinetics Tulathromycin Flunixin Intravenous |
| url | http://www.bsu.edu.eg/bsujournals/Content.aspx?paperId=464&cat_id=1 |
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