The regulatory effect of total flavonoids of Sedum aizoon L. on oxidative stress in type 1 diabetic mice
In this study, the optimal extraction conditions for the total flavonoids of Sedum aizoon L. (STF) were optimized by response surface methodology. Evaluation of the antioxidant in vitro of STF, and modulatory effects of glucolipid metabolism, and oxidative stress in mice with type 1 diabetes mellitu...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2022-01-01
|
| Series: | Current Research in Food Science |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2665927122000995 |
| _version_ | 1811188386261630976 |
|---|---|
| author | Xin Qi Xin-tong Lu Xi-han Sun Chang-qing Lin Cheng-bi Cui |
| author_facet | Xin Qi Xin-tong Lu Xi-han Sun Chang-qing Lin Cheng-bi Cui |
| author_sort | Xin Qi |
| collection | DOAJ |
| description | In this study, the optimal extraction conditions for the total flavonoids of Sedum aizoon L. (STF) were optimized by response surface methodology. Evaluation of the antioxidant in vitro of STF, and modulatory effects of glucolipid metabolism, and oxidative stress in mice with type 1 diabetes mellitus (T1DM). STF showed good antioxidant capacity in vitro. STF could improve glucolipid metabolism, organ coefficients, and antioxidant stress enzymes in T1DM mice effectively, reduce the damage to liver tissue, and regulate redox imbalance in the organism by modulating the Nrf2/Keap1/ARE signaling pathway. The results of this study could provide a theoretical reference for the application of Sedum aizoon L. in the development of auxiliary hypoglycemic functional foods and improvement of diabetes. |
| first_indexed | 2024-04-11T14:19:29Z |
| format | Article |
| id | doaj.art-dd451453ca6a4a269e52a3b448e4efd6 |
| institution | Directory Open Access Journal |
| issn | 2665-9271 |
| language | English |
| last_indexed | 2024-04-11T14:19:29Z |
| publishDate | 2022-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Current Research in Food Science |
| spelling | doaj.art-dd451453ca6a4a269e52a3b448e4efd62022-12-22T04:19:07ZengElsevierCurrent Research in Food Science2665-92712022-01-01511401147The regulatory effect of total flavonoids of Sedum aizoon L. on oxidative stress in type 1 diabetic miceXin Qi0Xin-tong Lu1Xi-han Sun2Chang-qing Lin3Cheng-bi Cui4Key Laboratory of Natural Medicines of the Changbai Mountain, Ministry of Education, Yanbian University, Yanji, 133002, ChinaDepartment of Food Processing and Safety, College of Agricultural, Yanbian University, Yanji, 133002, ChinaFood Science and Engineering, Convergence College, Yanbian University, Yanji, 133002, ChinaMedical College, Yanbian University, Yanji, 133002, China; Corresponding author.Key Laboratory of Natural Medicines of the Changbai Mountain, Ministry of Education, Yanbian University, Yanji, 133002, China; Department of Food Processing and Safety, College of Agricultural, Yanbian University, Yanji, 133002, China; Food Science and Engineering, Convergence College, Yanbian University, Yanji, 133002, China; Corresponding author. Key Laboratory of Natural Medicines of the Changbai Mountain, Ministry of Education, Yanbian University, Yanji, 133002, China.In this study, the optimal extraction conditions for the total flavonoids of Sedum aizoon L. (STF) were optimized by response surface methodology. Evaluation of the antioxidant in vitro of STF, and modulatory effects of glucolipid metabolism, and oxidative stress in mice with type 1 diabetes mellitus (T1DM). STF showed good antioxidant capacity in vitro. STF could improve glucolipid metabolism, organ coefficients, and antioxidant stress enzymes in T1DM mice effectively, reduce the damage to liver tissue, and regulate redox imbalance in the organism by modulating the Nrf2/Keap1/ARE signaling pathway. The results of this study could provide a theoretical reference for the application of Sedum aizoon L. in the development of auxiliary hypoglycemic functional foods and improvement of diabetes.http://www.sciencedirect.com/science/article/pii/S2665927122000995Sedum aizoon L.Total flavonoidsHypoglycemicMechanism |
| spellingShingle | Xin Qi Xin-tong Lu Xi-han Sun Chang-qing Lin Cheng-bi Cui The regulatory effect of total flavonoids of Sedum aizoon L. on oxidative stress in type 1 diabetic mice Current Research in Food Science Sedum aizoon L. Total flavonoids Hypoglycemic Mechanism |
| title | The regulatory effect of total flavonoids of Sedum aizoon L. on oxidative stress in type 1 diabetic mice |
| title_full | The regulatory effect of total flavonoids of Sedum aizoon L. on oxidative stress in type 1 diabetic mice |
| title_fullStr | The regulatory effect of total flavonoids of Sedum aizoon L. on oxidative stress in type 1 diabetic mice |
| title_full_unstemmed | The regulatory effect of total flavonoids of Sedum aizoon L. on oxidative stress in type 1 diabetic mice |
| title_short | The regulatory effect of total flavonoids of Sedum aizoon L. on oxidative stress in type 1 diabetic mice |
| title_sort | regulatory effect of total flavonoids of sedum aizoon l on oxidative stress in type 1 diabetic mice |
| topic | Sedum aizoon L. Total flavonoids Hypoglycemic Mechanism |
| url | http://www.sciencedirect.com/science/article/pii/S2665927122000995 |
| work_keys_str_mv | AT xinqi theregulatoryeffectoftotalflavonoidsofsedumaizoonlonoxidativestressintype1diabeticmice AT xintonglu theregulatoryeffectoftotalflavonoidsofsedumaizoonlonoxidativestressintype1diabeticmice AT xihansun theregulatoryeffectoftotalflavonoidsofsedumaizoonlonoxidativestressintype1diabeticmice AT changqinglin theregulatoryeffectoftotalflavonoidsofsedumaizoonlonoxidativestressintype1diabeticmice AT chengbicui theregulatoryeffectoftotalflavonoidsofsedumaizoonlonoxidativestressintype1diabeticmice AT xinqi regulatoryeffectoftotalflavonoidsofsedumaizoonlonoxidativestressintype1diabeticmice AT xintonglu regulatoryeffectoftotalflavonoidsofsedumaizoonlonoxidativestressintype1diabeticmice AT xihansun regulatoryeffectoftotalflavonoidsofsedumaizoonlonoxidativestressintype1diabeticmice AT changqinglin regulatoryeffectoftotalflavonoidsofsedumaizoonlonoxidativestressintype1diabeticmice AT chengbicui regulatoryeffectoftotalflavonoidsofsedumaizoonlonoxidativestressintype1diabeticmice |