Temocillin: Applications in Antimicrobial Stewardship as a Potential Carbapenem-Sparing Antibiotic
Temocillin is an old antibiotic, but given its particular characteristics, it may be a suitable alternative to carbapenems for treating infections due to ESBL-producing <i>Enterobacterales</i> and uncomplicated UTI due to KPC-producers. In this narrative review, the main research questio...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-04-01
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| Series: | Antibiotics |
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| Online Access: | https://www.mdpi.com/2079-6382/11/4/493 |
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| author | Tommaso Lupia Ilaria De Benedetto Giacomo Stroffolini Stefano Di Bella Simone Mornese Pinna Verena Zerbato Barbara Rizzello Roberta Bosio Nour Shbaklo Silvia Corcione Francesco Giuseppe De Rosa |
| author_facet | Tommaso Lupia Ilaria De Benedetto Giacomo Stroffolini Stefano Di Bella Simone Mornese Pinna Verena Zerbato Barbara Rizzello Roberta Bosio Nour Shbaklo Silvia Corcione Francesco Giuseppe De Rosa |
| author_sort | Tommaso Lupia |
| collection | DOAJ |
| description | Temocillin is an old antibiotic, but given its particular characteristics, it may be a suitable alternative to carbapenems for treating infections due to ESBL-producing <i>Enterobacterales</i> and uncomplicated UTI due to KPC-producers. In this narrative review, the main research question was to summarize current evidence on temocillin and its uses in infectious diseases. A search was run on PubMed using the terms (‘Temocillin’ [Mesh]) AND (‘Infection’ [Mesh]). Current knowledge regarding temocillin in urinary tract infection, blood-stream infections, pneumonia, intra-abdominal infections, central nervous system infections, skin and soft tissues infections, surgical sites infections and osteoarticular Infections were summarized. Temocillin retain a favourable profile on microbiota and risk of <i>Clostridioides difficile</i> infections and could be an option for treating outpatients. Temocillin may be a valuable tool to treat susceptible pathogens and for which a carbapenem could be spared. Other advantages in temocillin use are that it is well-tolerated; it is associated with a low rate of <i>C. difficile</i> infections; it is active against ESBL, AmpC, and KPC-producing <i>Enterobacterales</i>; and it can be used in the OPAT clinical setting. |
| first_indexed | 2024-03-09T11:15:24Z |
| format | Article |
| id | doaj.art-dd4621f7450d44089b8dd6bda4d70a8e |
| institution | Directory Open Access Journal |
| issn | 2079-6382 |
| language | English |
| last_indexed | 2024-03-09T11:15:24Z |
| publishDate | 2022-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antibiotics |
| spelling | doaj.art-dd4621f7450d44089b8dd6bda4d70a8e2023-12-01T00:32:50ZengMDPI AGAntibiotics2079-63822022-04-0111449310.3390/antibiotics11040493Temocillin: Applications in Antimicrobial Stewardship as a Potential Carbapenem-Sparing AntibioticTommaso Lupia0Ilaria De Benedetto1Giacomo Stroffolini2Stefano Di Bella3Simone Mornese Pinna4Verena Zerbato5Barbara Rizzello6Roberta Bosio7Nour Shbaklo8Silvia Corcione9Francesco Giuseppe De Rosa10Unit of Infectious Diseases, Cardinal Massaia, 14100 Asti, ItalyDepartment of Medical Sciences, Infectious Diseases, University of Turin, 10126 Turin, ItalyDepartment of Medical Sciences, Infectious Diseases, University of Turin, 10126 Turin, ItalyDepartment of Medical, Surgical and Health Sciences, University of Trieste, 34127 Trieste, ItalyDepartment of Medical Sciences, Infectious Diseases, University of Turin, 10126 Turin, ItalyInfectious Diseases Unit, Trieste University Hospital (ASUGI), 34125 Trieste, ItalyDepartment of Medical Sciences, Infectious Diseases, University of Turin, 10126 Turin, ItalyDepartment of Medical Sciences, Infectious Diseases, University of Turin, 10126 Turin, ItalyDepartment of Medical Sciences, Infectious Diseases, University of Turin, 10126 Turin, ItalyDepartment of Medical Sciences, Infectious Diseases, University of Turin, 10126 Turin, ItalyUnit of Infectious Diseases, Cardinal Massaia, 14100 Asti, ItalyTemocillin is an old antibiotic, but given its particular characteristics, it may be a suitable alternative to carbapenems for treating infections due to ESBL-producing <i>Enterobacterales</i> and uncomplicated UTI due to KPC-producers. In this narrative review, the main research question was to summarize current evidence on temocillin and its uses in infectious diseases. A search was run on PubMed using the terms (‘Temocillin’ [Mesh]) AND (‘Infection’ [Mesh]). Current knowledge regarding temocillin in urinary tract infection, blood-stream infections, pneumonia, intra-abdominal infections, central nervous system infections, skin and soft tissues infections, surgical sites infections and osteoarticular Infections were summarized. Temocillin retain a favourable profile on microbiota and risk of <i>Clostridioides difficile</i> infections and could be an option for treating outpatients. Temocillin may be a valuable tool to treat susceptible pathogens and for which a carbapenem could be spared. Other advantages in temocillin use are that it is well-tolerated; it is associated with a low rate of <i>C. difficile</i> infections; it is active against ESBL, AmpC, and KPC-producing <i>Enterobacterales</i>; and it can be used in the OPAT clinical setting.https://www.mdpi.com/2079-6382/11/4/493temocillinantimicrobial stewardshipsparing strategy |
| spellingShingle | Tommaso Lupia Ilaria De Benedetto Giacomo Stroffolini Stefano Di Bella Simone Mornese Pinna Verena Zerbato Barbara Rizzello Roberta Bosio Nour Shbaklo Silvia Corcione Francesco Giuseppe De Rosa Temocillin: Applications in Antimicrobial Stewardship as a Potential Carbapenem-Sparing Antibiotic Antibiotics temocillin antimicrobial stewardship sparing strategy |
| title | Temocillin: Applications in Antimicrobial Stewardship as a Potential Carbapenem-Sparing Antibiotic |
| title_full | Temocillin: Applications in Antimicrobial Stewardship as a Potential Carbapenem-Sparing Antibiotic |
| title_fullStr | Temocillin: Applications in Antimicrobial Stewardship as a Potential Carbapenem-Sparing Antibiotic |
| title_full_unstemmed | Temocillin: Applications in Antimicrobial Stewardship as a Potential Carbapenem-Sparing Antibiotic |
| title_short | Temocillin: Applications in Antimicrobial Stewardship as a Potential Carbapenem-Sparing Antibiotic |
| title_sort | temocillin applications in antimicrobial stewardship as a potential carbapenem sparing antibiotic |
| topic | temocillin antimicrobial stewardship sparing strategy |
| url | https://www.mdpi.com/2079-6382/11/4/493 |
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