Fighting Antimicrobial Resistance in Neonatal Intensive Care Units: Rational Use of Antibiotics in Neonatal Sepsis
Antibiotics are the most frequently prescribed drugs in neonatal intensive care units (NICUs) due to the severity of complications accompanying neonatal sepsis. However, antimicrobial drugs are often used inappropriately due to the difficulties in diagnosing sepsis in the neonatal population. The re...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-03-01
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| Series: | Antibiotics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2079-6382/12/3/508 |
| _version_ | 1797613883727282176 |
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| author | Dimitrios Rallis Vasileios Giapros Anastasios Serbis Chrysoula Kosmeri Maria Baltogianni |
| author_facet | Dimitrios Rallis Vasileios Giapros Anastasios Serbis Chrysoula Kosmeri Maria Baltogianni |
| author_sort | Dimitrios Rallis |
| collection | DOAJ |
| description | Antibiotics are the most frequently prescribed drugs in neonatal intensive care units (NICUs) due to the severity of complications accompanying neonatal sepsis. However, antimicrobial drugs are often used inappropriately due to the difficulties in diagnosing sepsis in the neonatal population. The reckless use of antibiotics leads to the development of resistant strains, rendering multidrug-resistant pathogens a serious problem in NICUs and a global threat to public health. The aim of this narrative review is to provide a brief overview of neonatal sepsis and an update on the data regarding indications for antimicrobial therapy initiation, current guidance in the empirical antimicrobial selection and duration of therapy, and indications for early discontinuation. |
| first_indexed | 2024-03-11T07:02:01Z |
| format | Article |
| id | doaj.art-dd46976ae46d484d8cacc953cd0ff16b |
| institution | Directory Open Access Journal |
| issn | 2079-6382 |
| language | English |
| last_indexed | 2024-03-11T07:02:01Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antibiotics |
| spelling | doaj.art-dd46976ae46d484d8cacc953cd0ff16b2023-11-17T09:13:59ZengMDPI AGAntibiotics2079-63822023-03-0112350810.3390/antibiotics12030508Fighting Antimicrobial Resistance in Neonatal Intensive Care Units: Rational Use of Antibiotics in Neonatal SepsisDimitrios Rallis0Vasileios Giapros1Anastasios Serbis2Chrysoula Kosmeri3Maria Baltogianni4Neonatal Intensive Care Unit, School of Medicine, University of Ioannina, 451 10 Ioannina, GreeceNeonatal Intensive Care Unit, School of Medicine, University of Ioannina, 451 10 Ioannina, GreeceDepartment of Paediatrics, School of Medicine, University of Ioannina, 451 10 Ioannina, GreeceDepartment of Paediatrics, School of Medicine, University of Ioannina, 451 10 Ioannina, GreeceNeonatal Intensive Care Unit, School of Medicine, University of Ioannina, 451 10 Ioannina, GreeceAntibiotics are the most frequently prescribed drugs in neonatal intensive care units (NICUs) due to the severity of complications accompanying neonatal sepsis. However, antimicrobial drugs are often used inappropriately due to the difficulties in diagnosing sepsis in the neonatal population. The reckless use of antibiotics leads to the development of resistant strains, rendering multidrug-resistant pathogens a serious problem in NICUs and a global threat to public health. The aim of this narrative review is to provide a brief overview of neonatal sepsis and an update on the data regarding indications for antimicrobial therapy initiation, current guidance in the empirical antimicrobial selection and duration of therapy, and indications for early discontinuation.https://www.mdpi.com/2079-6382/12/3/508early-onset sepsisextended-spectrum beta-lactamaseslate-onset sepsismultidrug resistancecarbapenem-resistant enterobacteriaceae |
| spellingShingle | Dimitrios Rallis Vasileios Giapros Anastasios Serbis Chrysoula Kosmeri Maria Baltogianni Fighting Antimicrobial Resistance in Neonatal Intensive Care Units: Rational Use of Antibiotics in Neonatal Sepsis Antibiotics early-onset sepsis extended-spectrum beta-lactamases late-onset sepsis multidrug resistance carbapenem-resistant enterobacteriaceae |
| title | Fighting Antimicrobial Resistance in Neonatal Intensive Care Units: Rational Use of Antibiotics in Neonatal Sepsis |
| title_full | Fighting Antimicrobial Resistance in Neonatal Intensive Care Units: Rational Use of Antibiotics in Neonatal Sepsis |
| title_fullStr | Fighting Antimicrobial Resistance in Neonatal Intensive Care Units: Rational Use of Antibiotics in Neonatal Sepsis |
| title_full_unstemmed | Fighting Antimicrobial Resistance in Neonatal Intensive Care Units: Rational Use of Antibiotics in Neonatal Sepsis |
| title_short | Fighting Antimicrobial Resistance in Neonatal Intensive Care Units: Rational Use of Antibiotics in Neonatal Sepsis |
| title_sort | fighting antimicrobial resistance in neonatal intensive care units rational use of antibiotics in neonatal sepsis |
| topic | early-onset sepsis extended-spectrum beta-lactamases late-onset sepsis multidrug resistance carbapenem-resistant enterobacteriaceae |
| url | https://www.mdpi.com/2079-6382/12/3/508 |
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