Hepatocellular carcinoma detection via targeted enzymatic methyl sequencing of plasma cell-free DNA

Hepatocellular carcinoma detection via targeted enzymatic methyl sequencing of plasma cell-free DNA

Abstract Background Epigenetic variants carried by circulating tumor DNA can be used as biomarkers for early detection of hepatocellular carcinoma (HCC) by noninvasive liquid biopsy. However, traditional methylation analysis method, bisulfite sequencing, with disadvantages of severe DNA damage, is l...

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Bibliographic Details
Main Authors: Ping Guo, Hailing Zheng, Yihan Li, Yuntong Li, Yue Xiao, Jin Zheng, Xingqiang Zhu, Huan Xu, Zhi He, Qian Zhang, Jinchun Chen, Mingshan Qiu, Min Jiang, Pingguo Liu, Hongliang Chen
Format: Article
Language:English
Published: BMC 2023-01-01
Series:Clinical Epigenetics
Subjects:
Enzymatic methyl sequencing
Liquid biopsy
Hepatocellular carcinoma
Cancer screening
Incomplete Conversion
Online Access:https://doi.org/10.1186/s13148-022-01420-6

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