Z-FL-COCHO, a cathepsin S inhibitor, enhances oxaliplatin-mediated apoptosis through the induction of endoplasmic reticulum stress
Cancer: Enhancing sensitivity to anti-cancer drugs A drug that inhibits a key cancer enzyme could be used in combination with anti-cancer drugs to improve sensitivity to treatment. The intracellular endoplasmic reticulum (ER) is involved in several vital processes in cells, including folding and pro...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2018-08-01
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| Series: | Experimental and Molecular Medicine |
| Online Access: | https://doi.org/10.1038/s12276-018-0138-6 |
| _version_ | 1818329718653452288 |
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| author | Seung Un Seo Kyoung-jin Min Seon Min Woo Taeg Kyu Kwon |
| author_facet | Seung Un Seo Kyoung-jin Min Seon Min Woo Taeg Kyu Kwon |
| author_sort | Seung Un Seo |
| collection | DOAJ |
| description | Cancer: Enhancing sensitivity to anti-cancer drugs A drug that inhibits a key cancer enzyme could be used in combination with anti-cancer drugs to improve sensitivity to treatment. The intracellular endoplasmic reticulum (ER) is involved in several vital processes in cells, including folding and processing proteins. Taeg Kyu Kwon at Keimyung University, Daegu, South Korea, and co-workers have demonstrated how inhibition of cathepsin S, which is expressed in many cancer cells, induces ER stress. In trials on human kidney cancer cells grafted onto mice and in vitro, the team found that ZFL (cathepsin S inhibitor) triggered transient ER stress by increasing calcium levels inside cells. Subsequent treatment with the anti-cancer drug oxaliplatin resulted in increased cancer cell death. |
| first_indexed | 2024-12-13T12:52:31Z |
| format | Article |
| id | doaj.art-dd49042f91834a9387e430c71941b380 |
| institution | Directory Open Access Journal |
| issn | 2092-6413 |
| language | English |
| last_indexed | 2024-12-13T12:52:31Z |
| publishDate | 2018-08-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | Experimental and Molecular Medicine |
| spelling | doaj.art-dd49042f91834a9387e430c71941b3802022-12-21T23:45:17ZengNature Publishing GroupExperimental and Molecular Medicine2092-64132018-08-0150811110.1038/s12276-018-0138-6Z-FL-COCHO, a cathepsin S inhibitor, enhances oxaliplatin-mediated apoptosis through the induction of endoplasmic reticulum stressSeung Un Seo0Kyoung-jin Min1Seon Min Woo2Taeg Kyu Kwon3Department of Immunology, School of Medicine, Keimyung UniversityDepartment of Immunology, School of Medicine, Keimyung UniversityDepartment of Immunology, School of Medicine, Keimyung UniversityDepartment of Immunology, School of Medicine, Keimyung UniversityCancer: Enhancing sensitivity to anti-cancer drugs A drug that inhibits a key cancer enzyme could be used in combination with anti-cancer drugs to improve sensitivity to treatment. The intracellular endoplasmic reticulum (ER) is involved in several vital processes in cells, including folding and processing proteins. Taeg Kyu Kwon at Keimyung University, Daegu, South Korea, and co-workers have demonstrated how inhibition of cathepsin S, which is expressed in many cancer cells, induces ER stress. In trials on human kidney cancer cells grafted onto mice and in vitro, the team found that ZFL (cathepsin S inhibitor) triggered transient ER stress by increasing calcium levels inside cells. Subsequent treatment with the anti-cancer drug oxaliplatin resulted in increased cancer cell death.https://doi.org/10.1038/s12276-018-0138-6 |
| spellingShingle | Seung Un Seo Kyoung-jin Min Seon Min Woo Taeg Kyu Kwon Z-FL-COCHO, a cathepsin S inhibitor, enhances oxaliplatin-mediated apoptosis through the induction of endoplasmic reticulum stress Experimental and Molecular Medicine |
| title | Z-FL-COCHO, a cathepsin S inhibitor, enhances oxaliplatin-mediated apoptosis through the induction of endoplasmic reticulum stress |
| title_full | Z-FL-COCHO, a cathepsin S inhibitor, enhances oxaliplatin-mediated apoptosis through the induction of endoplasmic reticulum stress |
| title_fullStr | Z-FL-COCHO, a cathepsin S inhibitor, enhances oxaliplatin-mediated apoptosis through the induction of endoplasmic reticulum stress |
| title_full_unstemmed | Z-FL-COCHO, a cathepsin S inhibitor, enhances oxaliplatin-mediated apoptosis through the induction of endoplasmic reticulum stress |
| title_short | Z-FL-COCHO, a cathepsin S inhibitor, enhances oxaliplatin-mediated apoptosis through the induction of endoplasmic reticulum stress |
| title_sort | z fl cocho a cathepsin s inhibitor enhances oxaliplatin mediated apoptosis through the induction of endoplasmic reticulum stress |
| url | https://doi.org/10.1038/s12276-018-0138-6 |
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