Do Circulating Histones Represent the Missing Link among COVID-19 Infection and Multiorgan Injuries, Microvascular Coagulopathy and Systemic Hyperinflammation?
Several studies shed light on the interplay among inflammation, thrombosis, multi-organ failures and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Increasing levels of both free and/or circulating histones have been associated to coronavirus disease 2019 (COVID-19), enhanci...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-03-01
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| Series: | Journal of Clinical Medicine |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2077-0383/11/7/1800 |
| _version_ | 1797438828760268800 |
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| author | Daniela Ligi Rosanna Maniscalco Mario Plebani Giuseppe Lippi Ferdinando Mannello |
| author_facet | Daniela Ligi Rosanna Maniscalco Mario Plebani Giuseppe Lippi Ferdinando Mannello |
| author_sort | Daniela Ligi |
| collection | DOAJ |
| description | Several studies shed light on the interplay among inflammation, thrombosis, multi-organ failures and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Increasing levels of both free and/or circulating histones have been associated to coronavirus disease 2019 (COVID-19), enhancing the risk of heart attack and stroke with coagulopathy and systemic hyperinflammation. In this view, by considering both the biological and clinical rationale, circulating histones may be relevant as diagnostic biomarkers for stratifying COVID-19 patients at higher risk for viral sepsis, and as predictive laboratory medicine tool for targeted therapies. |
| first_indexed | 2024-03-09T11:43:57Z |
| format | Article |
| id | doaj.art-dd4a98269b3846bbaa9117204c308940 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-09T11:43:57Z |
| publishDate | 2022-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-dd4a98269b3846bbaa9117204c3089402023-11-30T23:27:02ZengMDPI AGJournal of Clinical Medicine2077-03832022-03-01117180010.3390/jcm11071800Do Circulating Histones Represent the Missing Link among COVID-19 Infection and Multiorgan Injuries, Microvascular Coagulopathy and Systemic Hyperinflammation?Daniela Ligi0Rosanna Maniscalco1Mario Plebani2Giuseppe Lippi3Ferdinando Mannello4Unit of Clinical Biochemistry, Department of Biomolecular Sciences—DISB, University of Urbino Carlo Bo, 61029 Urbino, ItalyUnit of Clinical Biochemistry, Department of Biomolecular Sciences—DISB, University of Urbino Carlo Bo, 61029 Urbino, ItalyDepartment of Medicine—DIMED, University of Padua, 35128 Padua, ItalySection of Clinical Biochemistry, University Hospital of Verona, 37134 Verona, ItalyUnit of Clinical Biochemistry, Department of Biomolecular Sciences—DISB, University of Urbino Carlo Bo, 61029 Urbino, ItalySeveral studies shed light on the interplay among inflammation, thrombosis, multi-organ failures and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Increasing levels of both free and/or circulating histones have been associated to coronavirus disease 2019 (COVID-19), enhancing the risk of heart attack and stroke with coagulopathy and systemic hyperinflammation. In this view, by considering both the biological and clinical rationale, circulating histones may be relevant as diagnostic biomarkers for stratifying COVID-19 patients at higher risk for viral sepsis, and as predictive laboratory medicine tool for targeted therapies.https://www.mdpi.com/2077-0383/11/7/1800histoneCOVID-19coagulopathycytokine storminflammationmultiorgan injury |
| spellingShingle | Daniela Ligi Rosanna Maniscalco Mario Plebani Giuseppe Lippi Ferdinando Mannello Do Circulating Histones Represent the Missing Link among COVID-19 Infection and Multiorgan Injuries, Microvascular Coagulopathy and Systemic Hyperinflammation? Journal of Clinical Medicine histone COVID-19 coagulopathy cytokine storm inflammation multiorgan injury |
| title | Do Circulating Histones Represent the Missing Link among COVID-19 Infection and Multiorgan Injuries, Microvascular Coagulopathy and Systemic Hyperinflammation? |
| title_full | Do Circulating Histones Represent the Missing Link among COVID-19 Infection and Multiorgan Injuries, Microvascular Coagulopathy and Systemic Hyperinflammation? |
| title_fullStr | Do Circulating Histones Represent the Missing Link among COVID-19 Infection and Multiorgan Injuries, Microvascular Coagulopathy and Systemic Hyperinflammation? |
| title_full_unstemmed | Do Circulating Histones Represent the Missing Link among COVID-19 Infection and Multiorgan Injuries, Microvascular Coagulopathy and Systemic Hyperinflammation? |
| title_short | Do Circulating Histones Represent the Missing Link among COVID-19 Infection and Multiorgan Injuries, Microvascular Coagulopathy and Systemic Hyperinflammation? |
| title_sort | do circulating histones represent the missing link among covid 19 infection and multiorgan injuries microvascular coagulopathy and systemic hyperinflammation |
| topic | histone COVID-19 coagulopathy cytokine storm inflammation multiorgan injury |
| url | https://www.mdpi.com/2077-0383/11/7/1800 |
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