Age-dependent NK cell dysfunctions in severe COVID-19 patients

Age-dependent NK cell dysfunctions in severe COVID-19 patients

Natural Killer (NK) cells are key innate effectors of antiviral immune response, and their activity changes in ageing and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Here, we investigated the age-related changes of NK cell phenotype and function during SARS-CoV-2 infectio...

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Bibliographic Details
Main Authors: Cinzia Fionda, Silvia Ruggeri, Giuseppe Sciumè, Mattia Laffranchi, Isabella Quinti, Cinzia Milito, Paolo Palange, Ilaria Menichini, Silvano Sozzani, Luigi Frati, Angela Gismondi, Angela Santoni, Helena Stabile
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-11-01
Series:Frontiers in Immunology
Subjects:
Natural Killer cells
NK cell subsets
COVID-19
ageing
inflammation
T-BET
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.1039120/full

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