Echocardiographic index E/e' in association with cerebral white matter hyperintensity progression.
Cerebral white-matter hyperintensities (WMHs) on MRI is associated with reduced compliance of the cerebral arterioles. We hypothesized that an echocardiography index for left ventricular (LV) diastolic function, E/e', might reflect the cerebral arteriolar compliance and evaluated the associatio...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2020-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0236473 |
| _version_ | 1818916790370041856 |
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| author | Woo-Jin Lee Keun-Hwa Jung Young Jin Ryu Soon-Tae Lee Kyung-Il Park Kon Chu Manho Kim Sang Kun Lee Jae-Kyu Roh |
| author_facet | Woo-Jin Lee Keun-Hwa Jung Young Jin Ryu Soon-Tae Lee Kyung-Il Park Kon Chu Manho Kim Sang Kun Lee Jae-Kyu Roh |
| author_sort | Woo-Jin Lee |
| collection | DOAJ |
| description | Cerebral white-matter hyperintensities (WMHs) on MRI is associated with reduced compliance of the cerebral arterioles. We hypothesized that an echocardiography index for left ventricular (LV) diastolic function, E/e', might reflect the cerebral arteriolar compliance and evaluated the association between E/e' and long-term progression rate of the cerebral WMH volume. This retrospective study included individuals who were ≥ 50 years of age, with a preserved LV ejection fraction (≥ 50%) and neurological function status (modified Rankin scale score ≤1), and underwent initial and follow-up MRI evaluations within intervals of 34-45 months. Baseline clinical, laboratory, and echocardiography markers such as ejection fraction, LV mass index, and E/e' were obtained. WMH volume progression rate between the baseline and follow-up MRIs was designated as the outcome factor. 392 individuals (57.1% men; mean age: 66.7±8.4 years) were followed-up for 38.2±3.4 months. The mean WMH volume progression rate was 1.35±2.65 mL/year. The log-transformed value of WMH volume progression rate was linearly associated with the log-transformed E/e' (B coefficient = 0.365; 95% confidence interval [CI] 0.180-0.551; P = 0.001), along with the log-transformed values of baseline WMH volume (B = 0.142; 95% CI 0.106-0.179; P<0.001) and glomerular filtration rate (B = -0.182; 95% CI -0.321-0.044; P = 0.010). Additionally, a subgroup with an E/e' ≥15 exhibited a significantly higher WMH progression rate compared to the subgroups with lower E/e' values (P<0.001), especially in the lower quartiles (quartiles 1 and 2) of the baseline WMH volume. We concluded that echocardiographic marker E/e' is associated with the long-term progression rate of cerebral WMHs in population with preserved LV systolic function. |
| first_indexed | 2024-12-20T00:23:46Z |
| format | Article |
| id | doaj.art-dd4c25c65e224db687f3fb8d107d4598 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-20T00:23:46Z |
| publishDate | 2020-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-dd4c25c65e224db687f3fb8d107d45982022-12-21T20:00:08ZengPublic Library of Science (PLoS)PLoS ONE1932-62032020-01-01157e023647310.1371/journal.pone.0236473Echocardiographic index E/e' in association with cerebral white matter hyperintensity progression.Woo-Jin LeeKeun-Hwa JungYoung Jin RyuSoon-Tae LeeKyung-Il ParkKon ChuManho KimSang Kun LeeJae-Kyu RohCerebral white-matter hyperintensities (WMHs) on MRI is associated with reduced compliance of the cerebral arterioles. We hypothesized that an echocardiography index for left ventricular (LV) diastolic function, E/e', might reflect the cerebral arteriolar compliance and evaluated the association between E/e' and long-term progression rate of the cerebral WMH volume. This retrospective study included individuals who were ≥ 50 years of age, with a preserved LV ejection fraction (≥ 50%) and neurological function status (modified Rankin scale score ≤1), and underwent initial and follow-up MRI evaluations within intervals of 34-45 months. Baseline clinical, laboratory, and echocardiography markers such as ejection fraction, LV mass index, and E/e' were obtained. WMH volume progression rate between the baseline and follow-up MRIs was designated as the outcome factor. 392 individuals (57.1% men; mean age: 66.7±8.4 years) were followed-up for 38.2±3.4 months. The mean WMH volume progression rate was 1.35±2.65 mL/year. The log-transformed value of WMH volume progression rate was linearly associated with the log-transformed E/e' (B coefficient = 0.365; 95% confidence interval [CI] 0.180-0.551; P = 0.001), along with the log-transformed values of baseline WMH volume (B = 0.142; 95% CI 0.106-0.179; P<0.001) and glomerular filtration rate (B = -0.182; 95% CI -0.321-0.044; P = 0.010). Additionally, a subgroup with an E/e' ≥15 exhibited a significantly higher WMH progression rate compared to the subgroups with lower E/e' values (P<0.001), especially in the lower quartiles (quartiles 1 and 2) of the baseline WMH volume. We concluded that echocardiographic marker E/e' is associated with the long-term progression rate of cerebral WMHs in population with preserved LV systolic function.https://doi.org/10.1371/journal.pone.0236473 |
| spellingShingle | Woo-Jin Lee Keun-Hwa Jung Young Jin Ryu Soon-Tae Lee Kyung-Il Park Kon Chu Manho Kim Sang Kun Lee Jae-Kyu Roh Echocardiographic index E/e' in association with cerebral white matter hyperintensity progression. PLoS ONE |
| title | Echocardiographic index E/e' in association with cerebral white matter hyperintensity progression. |
| title_full | Echocardiographic index E/e' in association with cerebral white matter hyperintensity progression. |
| title_fullStr | Echocardiographic index E/e' in association with cerebral white matter hyperintensity progression. |
| title_full_unstemmed | Echocardiographic index E/e' in association with cerebral white matter hyperintensity progression. |
| title_short | Echocardiographic index E/e' in association with cerebral white matter hyperintensity progression. |
| title_sort | echocardiographic index e e in association with cerebral white matter hyperintensity progression |
| url | https://doi.org/10.1371/journal.pone.0236473 |
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