Ethylthiosulfanilate effect on Candida tropicalis
The problem of resistance of microorganisms to antibiotics stimulates the search for new chemotherapy drugs. Ethylthiosulfanilate (ETS, S-ethyl 4-amino-benzenesulfonothioate, S-ethyl ester of 4-aminobenzenethiosulfoacid) as a structural analog of number of phytoncides was synthesized based on thiosu...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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National Academy of Sciences of Ukraine, Palladin Institute of Biochemistry
2017-10-01
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| Series: | The Ukrainian Biochemical Journal |
| Subjects: | |
| Online Access: | http://ukrbiochemjournal.org/wp-content/uploads/2017/10/Oriabinska_5-17.pdf |
| _version_ | 1797641783138582528 |
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| author | L. B. Oriabinska S. О. Starovoitova S. V. Vasylyuk V. P. Novikov V. І. Lubenets |
| author_facet | L. B. Oriabinska S. О. Starovoitova S. V. Vasylyuk V. P. Novikov V. І. Lubenets |
| author_sort | L. B. Oriabinska |
| collection | DOAJ |
| description | The problem of resistance of microorganisms to antibiotics stimulates the search for new chemotherapy drugs. Ethylthiosulfanilate (ETS, S-ethyl 4-amino-benzenesulfonothioate, S-ethyl ester of 4-aminobenzenethiosulfoacid) as a structural analog of number of phytoncides was synthesized based on thiosulfoacid salts. ETS effect on opportunistic yeast fungi Candida tropicalis was studied. It was shown that ETS in subfungicidal concentration (125 µg/ml) affected some aspects of a constructive and energy metabolism of fungi: inhibited endogenous respiration and reduced the pool of nucleic acids. Additionaly the significant changes in lipogenesis of C. tropicalis were detected. It was established that ETS in fungistatic and subfungicidal concentrations possessed membranotropic effect and provided a high degree of cooperativity of structural transitions of membranes. |
| first_indexed | 2024-03-11T13:50:37Z |
| format | Article |
| id | doaj.art-dd4eee29b4244565ac9958f2a03e5742 |
| institution | Directory Open Access Journal |
| issn | 2409-4943 2413-5003 |
| language | English |
| last_indexed | 2024-03-11T13:50:37Z |
| publishDate | 2017-10-01 |
| publisher | National Academy of Sciences of Ukraine, Palladin Institute of Biochemistry |
| record_format | Article |
| series | The Ukrainian Biochemical Journal |
| spelling | doaj.art-dd4eee29b4244565ac9958f2a03e57422023-11-02T09:07:53ZengNational Academy of Sciences of Ukraine, Palladin Institute of BiochemistryThe Ukrainian Biochemical Journal2409-49432413-50032017-10-01895707610.15407/ubj89.05.070Ethylthiosulfanilate effect on Candida tropicalisL. B. Oriabinska0S. О. Starovoitova1S. V. Vasylyuk2V. P. Novikov3V. І. Lubenets4National Technical University of Ukraine “Igor Sikorsky Kyiv Polytechnic Institute”National University of Food Technologies, Kyiv, UkraineLviv Polytechnic National University, UkraineLviv Polytechnic National University, UkraineLviv Polytechnic National University, UkraineThe problem of resistance of microorganisms to antibiotics stimulates the search for new chemotherapy drugs. Ethylthiosulfanilate (ETS, S-ethyl 4-amino-benzenesulfonothioate, S-ethyl ester of 4-aminobenzenethiosulfoacid) as a structural analog of number of phytoncides was synthesized based on thiosulfoacid salts. ETS effect on opportunistic yeast fungi Candida tropicalis was studied. It was shown that ETS in subfungicidal concentration (125 µg/ml) affected some aspects of a constructive and energy metabolism of fungi: inhibited endogenous respiration and reduced the pool of nucleic acids. Additionaly the significant changes in lipogenesis of C. tropicalis were detected. It was established that ETS in fungistatic and subfungicidal concentrations possessed membranotropic effect and provided a high degree of cooperativity of structural transitions of membranes.http://ukrbiochemjournal.org/wp-content/uploads/2017/10/Oriabinska_5-17.pdfantimycotic actionCandida tropicalisethylthiosulfanilate effect |
| spellingShingle | L. B. Oriabinska S. О. Starovoitova S. V. Vasylyuk V. P. Novikov V. І. Lubenets Ethylthiosulfanilate effect on Candida tropicalis The Ukrainian Biochemical Journal antimycotic action Candida tropicalis ethylthiosulfanilate effect |
| title | Ethylthiosulfanilate effect on Candida tropicalis |
| title_full | Ethylthiosulfanilate effect on Candida tropicalis |
| title_fullStr | Ethylthiosulfanilate effect on Candida tropicalis |
| title_full_unstemmed | Ethylthiosulfanilate effect on Candida tropicalis |
| title_short | Ethylthiosulfanilate effect on Candida tropicalis |
| title_sort | ethylthiosulfanilate effect on candida tropicalis |
| topic | antimycotic action Candida tropicalis ethylthiosulfanilate effect |
| url | http://ukrbiochemjournal.org/wp-content/uploads/2017/10/Oriabinska_5-17.pdf |
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