Prognostic Value of Redox Status Biomarkers in Patients Presenting with STEMI or Non-STEMI: A Prospective Case-Control Clinical Study
(1) Background: The aim of our study was to determine the role of oxidative stress (OS) during early evaluation of acute ST-elevated myocardial infarction (STEMI) and non-ST-elevated myocardial infarction (NSTEMI) patients in order to define the role of redox balance in profiling the development of...
| Main Authors: | , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-06-01
|
| Series: | Journal of Personalized Medicine |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2075-4426/13/7/1050 |
| _version_ | 1797588729049645056 |
|---|---|
| author | Zorica Savovic Bozidar Pindovic Maja Nikolic Ivan Simic Goran Davidovic Vladimir Ignjatovic Jelena Vuckovic Nenad Zornic Tamara Nikolic Turnic Vladimir Zivkovic Ivan Srejovic Sergej Bolevich Vladimir Jakovljevic Violeta Iric Cupic |
| author_facet | Zorica Savovic Bozidar Pindovic Maja Nikolic Ivan Simic Goran Davidovic Vladimir Ignjatovic Jelena Vuckovic Nenad Zornic Tamara Nikolic Turnic Vladimir Zivkovic Ivan Srejovic Sergej Bolevich Vladimir Jakovljevic Violeta Iric Cupic |
| author_sort | Zorica Savovic |
| collection | DOAJ |
| description | (1) Background: The aim of our study was to determine the role of oxidative stress (OS) during early evaluation of acute ST-elevated myocardial infarction (STEMI) and non-ST-elevated myocardial infarction (NSTEMI) patients in order to define the role of redox balance in profiling the development of myocardial infarction (MI). (2) Methods: This prospective observational case-control study included 40 consecutive STEMI and 39 NSTEMI patients hospitalized in the coronary care unit of the cardiology clinic at the Kragujevac Clinical Center, Serbia, between 1 January 2016 and 1 January 2017. Blood samples were collected from all patients for measuring cardio-specific enzymes at admission and 12 h after admission to evaluate systemic oxidative stress biomarkers and the activity of antioxidant enzymes. (3) Results: In this study, participants were predominately female (52%), with a mean age of 56.17 ± 1.22 years old in the STEMI group and 69.17 ± 3.65 in the non-STEMI group. According to the Killip classification, the majority of patients (>50%) were at the second and third level. We confirmed the elevation of superoxide anion radicals in the non-STEMI group 6 h after admission in comparison with the STEMI and CTRL groups, but levels had decreased 12 h after admission. Levels of hydrogen peroxide were statistically significantly increased in the NSTEMI group. A positive correlation of superoxide anion radicals and levels of troponin I at admission was observed (r = 0.955; <i>p</i> = 0.045), as well as an inverse correlation between reduced glutathione and levels of NT-pBNP measured 6 h after admission (r = −0.973; <i>p</i> = 0.027). (4) Conclusions: We confirmed that superoxide anion radicals and reduced glutathione observed together with hs-troponin I at admission and NT-pBNP during hospital treatment could be predictors of ST evolution. |
| first_indexed | 2024-03-11T00:56:08Z |
| format | Article |
| id | doaj.art-dd502fe7636940a7a8ce9b76d644a7d1 |
| institution | Directory Open Access Journal |
| issn | 2075-4426 |
| language | English |
| last_indexed | 2024-03-11T00:56:08Z |
| publishDate | 2023-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Personalized Medicine |
| spelling | doaj.art-dd502fe7636940a7a8ce9b76d644a7d12023-11-18T20:02:50ZengMDPI AGJournal of Personalized Medicine2075-44262023-06-01137105010.3390/jpm13071050Prognostic Value of Redox Status Biomarkers in Patients Presenting with STEMI or Non-STEMI: A Prospective Case-Control Clinical StudyZorica Savovic0Bozidar Pindovic1Maja Nikolic2Ivan Simic3Goran Davidovic4Vladimir Ignjatovic5Jelena Vuckovic6Nenad Zornic7Tamara Nikolic Turnic8Vladimir Zivkovic9Ivan Srejovic10Sergej Bolevich11Vladimir Jakovljevic12Violeta Iric Cupic13Department of Internal Medicine, Faculty of Medical Sciences, University of Kragujevac, 34000 Kragujevac, SerbiaDepartment of Pharmacy, Faculty of Medical Sciences, University of Kragujevac, 34000 Kragujevac, SerbiaDepartment of Physiology, Faculty of Medical Sciences, University of Kragujevac, 34000 Kragujevac, SerbiaDepartment of Internal Medicine, Faculty of Medical Sciences, University of Kragujevac, 34000 Kragujevac, SerbiaDepartment of Internal Medicine, Faculty of Medical Sciences, University of Kragujevac, 34000 Kragujevac, SerbiaDepartment of Internal Medicine, Faculty of Medical Sciences, University of Kragujevac, 34000 Kragujevac, SerbiaDepartment of Internal Medicine, Faculty of Medical Sciences, University of Kragujevac, 34000 Kragujevac, SerbiaDepartment of Surgery, Faculty of Medical Sciences, University of Kragujevac, 34000 Kragujevac, SerbiaDepartment of Pharmacy, Faculty of Medical Sciences, University of Kragujevac, 34000 Kragujevac, SerbiaDepartment of Physiology, Faculty of Medical Sciences, University of Kragujevac, 34000 Kragujevac, SerbiaDepartment of Physiology, Faculty of Medical Sciences, University of Kragujevac, 34000 Kragujevac, SerbiaDepartment of Human Pathology, 1st Moscow State Medical, University I. M. Sechenov, 119991 Moscow, RussiaDepartment of Physiology, Faculty of Medical Sciences, University of Kragujevac, 34000 Kragujevac, SerbiaDepartment of Internal Medicine, Faculty of Medical Sciences, University of Kragujevac, 34000 Kragujevac, Serbia(1) Background: The aim of our study was to determine the role of oxidative stress (OS) during early evaluation of acute ST-elevated myocardial infarction (STEMI) and non-ST-elevated myocardial infarction (NSTEMI) patients in order to define the role of redox balance in profiling the development of myocardial infarction (MI). (2) Methods: This prospective observational case-control study included 40 consecutive STEMI and 39 NSTEMI patients hospitalized in the coronary care unit of the cardiology clinic at the Kragujevac Clinical Center, Serbia, between 1 January 2016 and 1 January 2017. Blood samples were collected from all patients for measuring cardio-specific enzymes at admission and 12 h after admission to evaluate systemic oxidative stress biomarkers and the activity of antioxidant enzymes. (3) Results: In this study, participants were predominately female (52%), with a mean age of 56.17 ± 1.22 years old in the STEMI group and 69.17 ± 3.65 in the non-STEMI group. According to the Killip classification, the majority of patients (>50%) were at the second and third level. We confirmed the elevation of superoxide anion radicals in the non-STEMI group 6 h after admission in comparison with the STEMI and CTRL groups, but levels had decreased 12 h after admission. Levels of hydrogen peroxide were statistically significantly increased in the NSTEMI group. A positive correlation of superoxide anion radicals and levels of troponin I at admission was observed (r = 0.955; <i>p</i> = 0.045), as well as an inverse correlation between reduced glutathione and levels of NT-pBNP measured 6 h after admission (r = −0.973; <i>p</i> = 0.027). (4) Conclusions: We confirmed that superoxide anion radicals and reduced glutathione observed together with hs-troponin I at admission and NT-pBNP during hospital treatment could be predictors of ST evolution.https://www.mdpi.com/2075-4426/13/7/1050acute coronary syndromemyocardial infarctionmyocardial reperfusionnon-ST-elevated myocardial infarctionbiomarkers of oxidative stressantioxidant capacity |
| spellingShingle | Zorica Savovic Bozidar Pindovic Maja Nikolic Ivan Simic Goran Davidovic Vladimir Ignjatovic Jelena Vuckovic Nenad Zornic Tamara Nikolic Turnic Vladimir Zivkovic Ivan Srejovic Sergej Bolevich Vladimir Jakovljevic Violeta Iric Cupic Prognostic Value of Redox Status Biomarkers in Patients Presenting with STEMI or Non-STEMI: A Prospective Case-Control Clinical Study Journal of Personalized Medicine acute coronary syndrome myocardial infarction myocardial reperfusion non-ST-elevated myocardial infarction biomarkers of oxidative stress antioxidant capacity |
| title | Prognostic Value of Redox Status Biomarkers in Patients Presenting with STEMI or Non-STEMI: A Prospective Case-Control Clinical Study |
| title_full | Prognostic Value of Redox Status Biomarkers in Patients Presenting with STEMI or Non-STEMI: A Prospective Case-Control Clinical Study |
| title_fullStr | Prognostic Value of Redox Status Biomarkers in Patients Presenting with STEMI or Non-STEMI: A Prospective Case-Control Clinical Study |
| title_full_unstemmed | Prognostic Value of Redox Status Biomarkers in Patients Presenting with STEMI or Non-STEMI: A Prospective Case-Control Clinical Study |
| title_short | Prognostic Value of Redox Status Biomarkers in Patients Presenting with STEMI or Non-STEMI: A Prospective Case-Control Clinical Study |
| title_sort | prognostic value of redox status biomarkers in patients presenting with stemi or non stemi a prospective case control clinical study |
| topic | acute coronary syndrome myocardial infarction myocardial reperfusion non-ST-elevated myocardial infarction biomarkers of oxidative stress antioxidant capacity |
| url | https://www.mdpi.com/2075-4426/13/7/1050 |
| work_keys_str_mv | AT zoricasavovic prognosticvalueofredoxstatusbiomarkersinpatientspresentingwithstemiornonstemiaprospectivecasecontrolclinicalstudy AT bozidarpindovic prognosticvalueofredoxstatusbiomarkersinpatientspresentingwithstemiornonstemiaprospectivecasecontrolclinicalstudy AT majanikolic prognosticvalueofredoxstatusbiomarkersinpatientspresentingwithstemiornonstemiaprospectivecasecontrolclinicalstudy AT ivansimic prognosticvalueofredoxstatusbiomarkersinpatientspresentingwithstemiornonstemiaprospectivecasecontrolclinicalstudy AT gorandavidovic prognosticvalueofredoxstatusbiomarkersinpatientspresentingwithstemiornonstemiaprospectivecasecontrolclinicalstudy AT vladimirignjatovic prognosticvalueofredoxstatusbiomarkersinpatientspresentingwithstemiornonstemiaprospectivecasecontrolclinicalstudy AT jelenavuckovic prognosticvalueofredoxstatusbiomarkersinpatientspresentingwithstemiornonstemiaprospectivecasecontrolclinicalstudy AT nenadzornic prognosticvalueofredoxstatusbiomarkersinpatientspresentingwithstemiornonstemiaprospectivecasecontrolclinicalstudy AT tamaranikolicturnic prognosticvalueofredoxstatusbiomarkersinpatientspresentingwithstemiornonstemiaprospectivecasecontrolclinicalstudy AT vladimirzivkovic prognosticvalueofredoxstatusbiomarkersinpatientspresentingwithstemiornonstemiaprospectivecasecontrolclinicalstudy AT ivansrejovic prognosticvalueofredoxstatusbiomarkersinpatientspresentingwithstemiornonstemiaprospectivecasecontrolclinicalstudy AT sergejbolevich prognosticvalueofredoxstatusbiomarkersinpatientspresentingwithstemiornonstemiaprospectivecasecontrolclinicalstudy AT vladimirjakovljevic prognosticvalueofredoxstatusbiomarkersinpatientspresentingwithstemiornonstemiaprospectivecasecontrolclinicalstudy AT violetairiccupic prognosticvalueofredoxstatusbiomarkersinpatientspresentingwithstemiornonstemiaprospectivecasecontrolclinicalstudy |