Research Progress of DNA Methylation in Cisplatin Resistance in Lung Cancer
As one of the most common malignant tumors, lung cancer poses a serious threat to human life and health. The platinum-based drug cisplatin (DDP) is used as the first-line treatment for lung cancer. The poor prognosis of lung cancer is mostly due to developed resistance to cisplatin, which poses a se...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | zho |
| Published: |
Chinese Anti-Cancer Association; Chinese Antituberculosis Association
2023-01-01
|
| Series: | Chinese Journal of Lung Cancer |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.3779/j.issn.1009-3419.2023.101.03 |
| _version_ | 1797905491759726592 |
|---|---|
| author | Jinzhe SUN Jun CHEN |
| author_facet | Jinzhe SUN Jun CHEN |
| author_sort | Jinzhe SUN |
| collection | DOAJ |
| description | As one of the most common malignant tumors, lung cancer poses a serious threat to human life and health. The platinum-based drug cisplatin (DDP) is used as the first-line treatment for lung cancer. The poor prognosis of lung cancer is mostly due to developed resistance to cisplatin, which poses a serious treatment challenge. The mechanism of cisplatin resistance is complex and unclear. Numerous studies have shown that DNA methylation plays a crucial role in the emergence of lung cancer cisplatin resistance. DNA hypermethylation results in the deactivation of numerous drug resistance genes and tumor suppressor genes through a change in chromatin conformation. Finding new therapeutic targets and indicators to predict the therapeutic effect can be aided by elucidating the complex mechanism. In order to discover novel strategies to overcome cisplatin resistance in lung cancer, this paper discusses DNA methylation-mediated cisplatin resistance and offers an overview of current demethylation procedures. |
| first_indexed | 2024-04-10T10:06:11Z |
| format | Article |
| id | doaj.art-dd5080e65d534f2db7723d792d582c5e |
| institution | Directory Open Access Journal |
| issn | 1009-3419 1999-6187 |
| language | zho |
| last_indexed | 2024-04-10T10:06:11Z |
| publishDate | 2023-01-01 |
| publisher | Chinese Anti-Cancer Association; Chinese Antituberculosis Association |
| record_format | Article |
| series | Chinese Journal of Lung Cancer |
| spelling | doaj.art-dd5080e65d534f2db7723d792d582c5e2023-02-16T00:55:34ZzhoChinese Anti-Cancer Association; Chinese Antituberculosis AssociationChinese Journal of Lung Cancer1009-34191999-61872023-01-01261525810.3779/j.issn.1009-3419.2023.101.03Research Progress of DNA Methylation in Cisplatin Resistance in Lung CancerJinzhe SUN0Jun CHEN1Department of Oncology, The Second Hospital of Dalian Medical University, Dalian 116000, ChinaDepartment of Oncology, The Second Hospital of Dalian Medical University, Dalian 116000, ChinaAs one of the most common malignant tumors, lung cancer poses a serious threat to human life and health. The platinum-based drug cisplatin (DDP) is used as the first-line treatment for lung cancer. The poor prognosis of lung cancer is mostly due to developed resistance to cisplatin, which poses a serious treatment challenge. The mechanism of cisplatin resistance is complex and unclear. Numerous studies have shown that DNA methylation plays a crucial role in the emergence of lung cancer cisplatin resistance. DNA hypermethylation results in the deactivation of numerous drug resistance genes and tumor suppressor genes through a change in chromatin conformation. Finding new therapeutic targets and indicators to predict the therapeutic effect can be aided by elucidating the complex mechanism. In order to discover novel strategies to overcome cisplatin resistance in lung cancer, this paper discusses DNA methylation-mediated cisplatin resistance and offers an overview of current demethylation procedures.http://dx.doi.org/10.3779/j.issn.1009-3419.2023.101.03lung neoplasmsdna methylationdemethylationcisplatindrug resistance |
| spellingShingle | Jinzhe SUN Jun CHEN Research Progress of DNA Methylation in Cisplatin Resistance in Lung Cancer Chinese Journal of Lung Cancer lung neoplasms dna methylation demethylation cisplatin drug resistance |
| title | Research Progress of DNA Methylation in Cisplatin Resistance in Lung Cancer |
| title_full | Research Progress of DNA Methylation in Cisplatin Resistance in Lung Cancer |
| title_fullStr | Research Progress of DNA Methylation in Cisplatin Resistance in Lung Cancer |
| title_full_unstemmed | Research Progress of DNA Methylation in Cisplatin Resistance in Lung Cancer |
| title_short | Research Progress of DNA Methylation in Cisplatin Resistance in Lung Cancer |
| title_sort | research progress of dna methylation in cisplatin resistance in lung cancer |
| topic | lung neoplasms dna methylation demethylation cisplatin drug resistance |
| url | http://dx.doi.org/10.3779/j.issn.1009-3419.2023.101.03 |
| work_keys_str_mv | AT jinzhesun researchprogressofdnamethylationincisplatinresistanceinlungcancer AT junchen researchprogressofdnamethylationincisplatinresistanceinlungcancer |