DA7R: A 7-Letter Zip Code to Target PDAC

DA7R: A 7-Letter Zip Code to Target PDAC

Pancreatic ductal adenocarcinoma (PDAC) is the most common type of pancreatic cancer, and is among the most aggressive and still incurable cancers. Innovative and successful therapeutic strategies are extremely needed. Peptides represent a versatile and promising tool to achieve tumor targeting, tha...

Full description

Bibliographic Details
Main Authors:	Sofia Parrasia, Andrea Rossa, Nicola Roncaglia, Andrea Mattarei, Claudia Honisch, Ildikò Szabò, Paolo Ruzza, Lucia Biasutto
Format:	Article
Language:	English
Published:	MDPI AG 2023-05-01
Series:	Pharmaceutics
Subjects:	pancreatic ductal adenocarcinoma (PDAC) A7R peptide neuropilin-1 (NRP-1) vascular endothelial growth factor receptor-2 (VEGFR2) PAPTP
Online Access:	https://www.mdpi.com/1999-4923/15/5/1508

Similar Items

An Angiopep2-PAPTP Construct Overcomes the Blood-Brain Barrier. New Perspectives against Brain Tumors
by: Sofia Parrasia, et al.
Published: (2021-02-01)

Neuropilin-1 expression is associated with lymph node metastasis in breast cancer tissues
by: Seifi-Alan M, et al.
Published: (2018-07-01)

Biological Hallmarks and New Therapeutic Approaches for the Treatment of PDAC
by: Graziana Digiacomo, et al.
Published: (2021-08-01)

Neuropilin-1 functions as a VEGFR2 co-receptor to guide developmental angiogenesis independent of ligand binding
by: Maria V Gelfand, et al.
Published: (2014-09-01)

The Role of Neuropilin-2 in the Epithelial to Mesenchymal Transition of Colorectal Cancer: A Systematic Review
by: Cristina Lungulescu, et al.
Published: (2022-01-01)

Tumor Necrosis Factor and Interleukin-1β Upregulate NRP2 Expression and Promote SARS-CoV-2 Proliferation
by: Michinori Ishitoku, et al.
Published: (2023-07-01)

L-theanine promotes angiogenesis in limb ischemic mice by modulating NRP1/VEGFR2 signaling
by: Jingyi Wang, et al.
Published: (2025-01-01)

In-silico natural product database mining for novel neuropilin-1 inhibitors: molecular docking, molecular dynamics and binding energy computations
by: Mahmoud A. A. Ibrahim, et al.
Published: (2023-12-01)

High co-expression of the SDF1/CXCR4 axis in hepatocarcinoma cells is regulated by AnnexinA7 in vitro and in vivo
by: Jingwen Wang, et al.
Published: (2018-05-01)

Integrated analysis of microbiome and metabolome reveals signatures in PDAC tumorigenesis and prognosis
by: Yuan Fang, et al.
Published: (2024-11-01)

Targeting Pancreatic Ductal Adenocarcinoma (PDAC)
by: Sofia Parrasia, et al.
Published: (2021-01-01)

Cell Lineage Infidelity in PDAC Progression and Therapy Resistance
by: Antonia Malinova, et al.
Published: (2021-12-01)

VEGFR-3 signaling in macrophages: friend or foe in disease?
by: Saranya Kannan, et al.
Published: (2024-02-01)

Semaphorin 3F (SEMA3F) influences patient survival in esophageal adenocarcinoma
by: Karl Knipper, et al.
Published: (2024-09-01)

Integration of metabolites from meta-analysis with transcriptome reveals enhanced SPHK1 in PDAC with a background of pancreatitis
by: Vijayasarathy Ketavarapu, et al.
Published: (2022-07-01)

Expression of sorting nexin 1 in pancreatic ductal adenocarcinoma and its mechanism in promoting PDAC progress
by: PAN Hong, et al.
Published: (2023-03-01)

Peptidomimetic inhibitors of the VEGF-A165/NRP-1 complex obtained by modification of the C-terminal arginine
by: Dagmara Tymecka, et al.
Published: (2024-08-01)

Neuropilin-1 Expression in Treg and PDC Cells in Peripheral Blood of Non-small Cell Lung Cancer Patients and Clinical Significance
by: SHI Xingyue, et al.
Published: (2020-07-01)

Vascular Endothelial Growth Factor Signaling in Models of Oxygen-Induced Retinopathy: Insights Into Mechanisms of Pathology in Retinopathy of Prematurity
by: Aniket Ramshekar, et al.
Published: (2021-12-01)

An insight to PDAC tumor heterogeneity across pancreatic subregions using computed tomography images
by: Sehrish Javed, et al.
Published: (2024-11-01)

LECT 2 Antagonizes FOXM1 Signaling via Inhibiting MET to Retard PDAC Progression
by: Xin Li, et al.
Published: (2021-04-01)

Analysis of PLXNA1, NRP1, and NRP2 variants in a cohort of patients with isolated hypogonadotropic hypogonadism
by: Meichao Men, et al.
Published: (2021-11-01)

The Co-Localization of NLRP3 and ASC Specks Does Not Automatically Entail NLRP3 Inflammasome Functionality in PDAC Cell Lines
by: Heléne Lindholm, et al.
Published: (2024-03-01)

A Dual Receptor Targeting- and BBB Penetrating- Peptide Functionalized Polyethyleneimine Nanocomplex for Secretory Endostatin Gene Delivery to Malignant Glioma
by: Lu L, et al.
Published: (2020-11-01)

Isoforms of Neuropilin-2 Denote Unique Tumor-Associated Macrophages in Breast Cancer
by: Rajeev Dhupar, et al.
Published: (2022-04-01)

From protein-protein interactions to immune modulation: Therapeutic prospects of targeting Neuropilin-1 in high-grade glioma
by: Gregory T. Smith, et al.
Published: (2022-09-01)

TOPBP1 as a potential predictive biomarker for enhanced combinatorial efficacy of olaparib and AZD6738 in PDAC
by: Xiao-Mei Tang, et al.
Published: (2025-02-01)

RelA Is an Essential Target for Enhancing Cellular Responses to the DNA Repair/Ref-1 Redox Signaling Protein and Restoring Perturbated Cellular Redox Homeostasis in Mouse PDAC Cells
by: Mahmut Mijit, et al.
Published: (2022-03-01)

Mutant SF3B1 promotes malignancy in PDAC
by: Patrik Simmler, et al.
Published: (2023-10-01)

The NRP1 migraine risk variant shows evidence of association with menstrual migraine
by: Charmaine E. Pollock, et al.
Published: (2018-04-01)

Differential neuropilin isoform expressions highlight plasticity in macrophages in the heterogenous TME through in-silico profiling
by: Hyun-Jee Han, et al.
Published: (2025-03-01)

Multifaceted Role of Neuropilins in the Immune System: Potential Targets for Immunotherapy
by: Sohini Roy, et al.
Published: (2017-10-01)

Combining molecular characteristics and therapeutic analysis of PDOs predict clinical responses and guide PDAC personalized treatment
by: Peng Li, et al.
Published: (2025-02-01)

Adult Pancreatoblastoma: Clinical Insights and Outcomes Compared to Pancreatic Ductal Adenocarcinoma (PDAC)
by: Han Yin, et al.
Published: (2024-08-01)

Is the effect of melatonin on vascular endothelial growth factor receptor-2 associated with angiogenesis in the rat ovary?
by: Yasemin Behram Kandemir, et al.
Published: (2019-03-01)

Structural Characterization of <i>Arabidopsis thaliana</i> NAP1-Related Protein 2 (AtNRP2) and Comparison with Its Homolog AtNRP1
by: Ashish Kumar, et al.
Published: (2019-06-01)

Discovery of novel PARP1/NRP1 dual-targeting inhibitors with strong antitumor potency
by: Juanjuan Liu, et al.
Published: (2024-11-01)

Linking NRP2 With EMT and Chemoradioresistance in Bladder Cancer
by: Alexander Schulz, et al.
Published: (2020-01-01)

Protease‐activated receptor 1 drives and maintains ductal cell fates in the premalignant pancreas and ductal adenocarcinoma
by: Cansu Tekin, et al.
Published: (2021-11-01)

VEGFA, VEGFR1, VEGFR2 serum and cerebrospinal fluid concentration in patients with acute leukemia
by: E. I. Zakharko, et al.
Published: (2024-04-01)