Macrophage-dependent IL-1β production induces cardiac arrhythmias in diabetic mice
Ventricular arrhythmia is a leading cause of death in patients with diabetes. Here the authors show that inflammasome activation and ILK-1β production in cardiac macrophages cause arrhythmia in diabetic mice, which can be successfully treated using agonists to IL-1β receptor or NLRP3 inhibitors.
Bibliographic Details
| Main Authors: |
Gustavo Monnerat,
Micaela L. Alarcón,
Luiz R. Vasconcellos,
Camila Hochman-Mendez,
Guilherme Brasil,
Rosana A. Bassani,
Oscar Casis,
Daniela Malan,
Leonardo H. Travassos,
Marisa Sepúlveda,
Juan Ignacio Burgos,
Martin Vila-Petroff,
Fabiano F. Dutra,
Marcelo T. Bozza,
Claudia N. Paiva,
Adriana Bastos Carvalho,
Adriana Bonomo,
Bernd K. Fleischmann,
Antonio Carlos Campos de Carvalho,
Emiliano Medei |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Portfolio
2016-11-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/ncomms13344
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