Macrophage-dependent IL-1β production induces cardiac arrhythmias in diabetic mice
Ventricular arrhythmia is a leading cause of death in patients with diabetes. Here the authors show that inflammasome activation and ILK-1β production in cardiac macrophages cause arrhythmia in diabetic mice, which can be successfully treated using agonists to IL-1β receptor or NLRP3 inhibitors.
| Main Authors: | , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2016-11-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/ncomms13344 |
| _version_ | 1819035723301388288 |
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| author | Gustavo Monnerat Micaela L. Alarcón Luiz R. Vasconcellos Camila Hochman-Mendez Guilherme Brasil Rosana A. Bassani Oscar Casis Daniela Malan Leonardo H. Travassos Marisa Sepúlveda Juan Ignacio Burgos Martin Vila-Petroff Fabiano F. Dutra Marcelo T. Bozza Claudia N. Paiva Adriana Bastos Carvalho Adriana Bonomo Bernd K. Fleischmann Antonio Carlos Campos de Carvalho Emiliano Medei |
| author_facet | Gustavo Monnerat Micaela L. Alarcón Luiz R. Vasconcellos Camila Hochman-Mendez Guilherme Brasil Rosana A. Bassani Oscar Casis Daniela Malan Leonardo H. Travassos Marisa Sepúlveda Juan Ignacio Burgos Martin Vila-Petroff Fabiano F. Dutra Marcelo T. Bozza Claudia N. Paiva Adriana Bastos Carvalho Adriana Bonomo Bernd K. Fleischmann Antonio Carlos Campos de Carvalho Emiliano Medei |
| author_sort | Gustavo Monnerat |
| collection | DOAJ |
| description | Ventricular arrhythmia is a leading cause of death in patients with diabetes. Here the authors show that inflammasome activation and ILK-1β production in cardiac macrophages cause arrhythmia in diabetic mice, which can be successfully treated using agonists to IL-1β receptor or NLRP3 inhibitors. |
| first_indexed | 2024-12-21T07:54:09Z |
| format | Article |
| id | doaj.art-dd521bbbf78046d888ba049b54d46e2e |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-21T07:54:09Z |
| publishDate | 2016-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-dd521bbbf78046d888ba049b54d46e2e2022-12-21T19:11:00ZengNature PortfolioNature Communications2041-17232016-11-017111510.1038/ncomms13344Macrophage-dependent IL-1β production induces cardiac arrhythmias in diabetic miceGustavo Monnerat0Micaela L. Alarcón1Luiz R. Vasconcellos2Camila Hochman-Mendez3Guilherme Brasil4Rosana A. Bassani5Oscar Casis6Daniela Malan7Leonardo H. Travassos8Marisa Sepúlveda9Juan Ignacio Burgos10Martin Vila-Petroff11Fabiano F. Dutra12Marcelo T. Bozza13Claudia N. Paiva14Adriana Bastos Carvalho15Adriana Bonomo16Bernd K. Fleischmann17Antonio Carlos Campos de Carvalho18Emiliano Medei19Institute of Biophysics Carlos Chagas Filho, Universidade Federal do Rio de JaneiroInstitute of Biophysics Carlos Chagas Filho, Universidade Federal do Rio de JaneiroLIRS-Laboratory of Immunoreceptors and Signaling, Universidade Federal do Rio de JaneiroInstitute of Biophysics Carlos Chagas Filho, Universidade Federal do Rio de JaneiroInstitute of Biophysics Carlos Chagas Filho, Universidade Federal do Rio de JaneiroCenter for Biomedical Engineering, University of CampinasDepartamento de Fisiología, Facultad de Farmacia, Universidad del País Vasco UPV/EHUInstitute of Physiology I, Life and Brain Center, University of BonnLIRS-Laboratory of Immunoreceptors and Signaling, Universidade Federal do Rio de JaneiroCentro de Investigaciones Cardiovasculares, Conicet La Plata, Facultad de Ciencias Médicas, Universidad Nacional de La PlataCentro de Investigaciones Cardiovasculares, Conicet La Plata, Facultad de Ciencias Médicas, Universidad Nacional de La PlataCentro de Investigaciones Cardiovasculares, Conicet La Plata, Facultad de Ciencias Médicas, Universidad Nacional de La PlataInstituto de Microbiologia, Universidade Federal do Rio de JaneiroInstituto de Microbiologia, Universidade Federal do Rio de JaneiroInstituto de Microbiologia, Universidade Federal do Rio de JaneiroInstitute of Biophysics Carlos Chagas Filho, Universidade Federal do Rio de JaneiroInstituto de Microbiologia, Universidade Federal do Rio de JaneiroInstitute of Physiology I, Life and Brain Center, University of BonnInstitute of Biophysics Carlos Chagas Filho, Universidade Federal do Rio de JaneiroInstitute of Biophysics Carlos Chagas Filho, Universidade Federal do Rio de JaneiroVentricular arrhythmia is a leading cause of death in patients with diabetes. Here the authors show that inflammasome activation and ILK-1β production in cardiac macrophages cause arrhythmia in diabetic mice, which can be successfully treated using agonists to IL-1β receptor or NLRP3 inhibitors.https://doi.org/10.1038/ncomms13344 |
| spellingShingle | Gustavo Monnerat Micaela L. Alarcón Luiz R. Vasconcellos Camila Hochman-Mendez Guilherme Brasil Rosana A. Bassani Oscar Casis Daniela Malan Leonardo H. Travassos Marisa Sepúlveda Juan Ignacio Burgos Martin Vila-Petroff Fabiano F. Dutra Marcelo T. Bozza Claudia N. Paiva Adriana Bastos Carvalho Adriana Bonomo Bernd K. Fleischmann Antonio Carlos Campos de Carvalho Emiliano Medei Macrophage-dependent IL-1β production induces cardiac arrhythmias in diabetic mice Nature Communications |
| title | Macrophage-dependent IL-1β production induces cardiac arrhythmias in diabetic mice |
| title_full | Macrophage-dependent IL-1β production induces cardiac arrhythmias in diabetic mice |
| title_fullStr | Macrophage-dependent IL-1β production induces cardiac arrhythmias in diabetic mice |
| title_full_unstemmed | Macrophage-dependent IL-1β production induces cardiac arrhythmias in diabetic mice |
| title_short | Macrophage-dependent IL-1β production induces cardiac arrhythmias in diabetic mice |
| title_sort | macrophage dependent il 1β production induces cardiac arrhythmias in diabetic mice |
| url | https://doi.org/10.1038/ncomms13344 |
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