Hepatotoxicidade à levofloxacina. Risco aumentado em diabéticos?
Levofloxacin, commonly used in medical practice, is prescribed to treat pneumonia in patients with comorbidities. Although generally well tolerated and safe, it has a well-known, but rarely reported, undercharacterized and ill-identified hepatotoxicity, with an unknown signature. With cases of fulmi...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Ordem dos Médicos
2011-12-01
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| Series: | Acta Médica Portuguesa |
| Online Access: | https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/1529 |
| _version_ | 1817980215114072064 |
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| author | Joana Coelho Carla Gonçalves Sara Leitão R Marques Dos Santos J Nascimento Costa |
| author_facet | Joana Coelho Carla Gonçalves Sara Leitão R Marques Dos Santos J Nascimento Costa |
| author_sort | Joana Coelho |
| collection | DOAJ |
| description | Levofloxacin, commonly used in medical practice, is prescribed to treat pneumonia in patients with comorbidities. Although generally well tolerated and safe, it has a well-known, but rarely reported, undercharacterized and ill-identified hepatotoxicity, with an unknown signature. With cases of fulminant hepatitis, cholestasis episodes reveal an apparently benign progression. Its capability of interference with the glucidic metabolism is also well-known, and the susceptibility factors to these events include age, presence of multiple pathologies and polymedication. The link between Diabetes Mellitus and hepatotoxicity has not yet been identified. Nonetheless, reports of several cases in literature along with the identification of two cases in insulin-treated diabetics, lead to believe that this is a higher-risk group. |
| first_indexed | 2024-04-13T22:51:39Z |
| format | Article |
| id | doaj.art-dd522ad8190f417190e863ca6e337f47 |
| institution | Directory Open Access Journal |
| issn | 0870-399X 1646-0758 |
| language | English |
| last_indexed | 2024-04-13T22:51:39Z |
| publishDate | 2011-12-01 |
| publisher | Ordem dos Médicos |
| record_format | Article |
| series | Acta Médica Portuguesa |
| spelling | doaj.art-dd522ad8190f417190e863ca6e337f472022-12-22T02:26:10ZengOrdem dos MédicosActa Médica Portuguesa0870-399X1646-07582011-12-012410.20344/amp.1529Hepatotoxicidade à levofloxacina. Risco aumentado em diabéticos?Joana Coelho0Carla GonçalvesSara LeitãoR Marques Dos SantosJ Nascimento CostaServiço de Medicina Interna, Hospitais da Universidade de Coimbra, Coimbra, Portugal.Levofloxacin, commonly used in medical practice, is prescribed to treat pneumonia in patients with comorbidities. Although generally well tolerated and safe, it has a well-known, but rarely reported, undercharacterized and ill-identified hepatotoxicity, with an unknown signature. With cases of fulminant hepatitis, cholestasis episodes reveal an apparently benign progression. Its capability of interference with the glucidic metabolism is also well-known, and the susceptibility factors to these events include age, presence of multiple pathologies and polymedication. The link between Diabetes Mellitus and hepatotoxicity has not yet been identified. Nonetheless, reports of several cases in literature along with the identification of two cases in insulin-treated diabetics, lead to believe that this is a higher-risk group.https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/1529 |
| spellingShingle | Joana Coelho Carla Gonçalves Sara Leitão R Marques Dos Santos J Nascimento Costa Hepatotoxicidade à levofloxacina. Risco aumentado em diabéticos? Acta Médica Portuguesa |
| title | Hepatotoxicidade à levofloxacina. Risco aumentado em diabéticos? |
| title_full | Hepatotoxicidade à levofloxacina. Risco aumentado em diabéticos? |
| title_fullStr | Hepatotoxicidade à levofloxacina. Risco aumentado em diabéticos? |
| title_full_unstemmed | Hepatotoxicidade à levofloxacina. Risco aumentado em diabéticos? |
| title_short | Hepatotoxicidade à levofloxacina. Risco aumentado em diabéticos? |
| title_sort | hepatotoxicidade a levofloxacina risco aumentado em diabeticos |
| url | https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/1529 |
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